Recombinant Chicken Growth hormone receptor (GHR), partial

Code CSB-YP009411CH1
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Source Yeast
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Code CSB-EP009411CH1
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Source E.coli
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Code CSB-EP009411CH1-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP009411CH1
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Source Baculovirus
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Code CSB-MP009411CH1
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Source Mammalian cell
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Product Details

>85% (SDS-PAGE)
Target Names
Uniprot No.
Alternative Names
GHR; Growth hormone receptor; GH receptor; Somatotropin receptor
Gallus gallus (Chicken)
Protein Length
Tag Info
The following tags are available.
N-terminal His-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Please contact us to get it.

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Target Background

Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway.; The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.
Gene References into Functions
  1. the molecular mechanisms underlying growth hormone receptor (GHR) in Sex-linked dwarf chickens, was examined. PMID: 27819736
  2. GHR mRNA was expressed in all examined oviductal segments with a significantly lower level in the infundibulum in comparison to other parts of the oviduct; specific GHR immunoreactivity was also detected in the wall of the oviduct. PMID: 24279179
  3. Between 3 and 6 wk of age, growth hormone receptor expression increased with age in adipose tissue. PMID: 22560177
  4. There is a critical miRNA, let-7b, involved in the regulation of GHR. PMID: 22781587
  5. Pectoralis major muscle GHR mRNA was greater in line of low weight than high weight selected chicken. PMID: 21500111
  6. These results support the possibility that GH acts as a local growth factor during early embryonic development of the visual system. PMID: 17618059
  7. The expression of GHR gene was more than 3-fold higher in dwarf chickens, compared with that of the normal. PMID: 17681929
  8. Growth hormone (GH) receptor mRNA was also detected within cells of the E7 retinal ganglion cells (RGC) layer and GH receptor protein colocalized with GH in RGC axons. PMID: 19213842

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Involvement in disease
Defects in GHR are a cause of sex-linked dwarf chicken. A restriction fragment length polymorphism, and an aberrantly-sized transcript in liver leads to a GHR with undetectable GH-binding activity causing growth deficiency and other endocrine abnormalities.
Subcellular Location
Cell membrane; Single-pass type I membrane protein. Note=On growth hormone binding, GHR is ubiquitinated, internalized, down-regulated and transported into a degradative or non-degradative pathway.
Protein Families
Type I cytokine receptor family, Type 1 subfamily
Tissue Specificity
Broad specificity.
Database Links
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