Recombinant Dog Collagen alpha-1 (I) chain (COL1A1), partial

Code CSB-YP894069DO
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Source Yeast
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Code CSB-EP894069DO
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Source E.coli
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Code CSB-EP894069DO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP894069DO
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Source Baculovirus
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Code CSB-MP894069DO
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
COL1A1
Uniprot No.
Alternative Names
COL1A1Collagen alpha-1(I) chain; Alpha-1 type I collagen
Species
Canis lupus familiaris (Dog) (Canis familiaris)
Protein Length
Partial
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Type I collagen is a member of group I collagen (fibrillar forming collagen).
Gene References into Functions
  1. obstructive sleep apnea can accelerate the progression of pulmonary remodeling through TGF-beta/miR-185/CoLA1 signaling PMID: 27542203
  2. Data show that heat shock protein 47 (HSP47/SERPINH1) double mutant with histidine His(273) and His(274) exchanged for asparagines exhibits a much less pronounced pH dependence of collagen binding. PMID: 27129216
  3. identified SNPs in key genes involved in ligament strength, stability and extracellular matrix formation (COL5A1, COL5A2, COL1A1, COL3A1, COL11A1, COL24A1, FBN1, LOX, LTBP2) which were significantly associated with CCLR susceptibility PMID: 24684544
  4. both galectin-3 and -9 are required for optimal long term cell adhesion to both collagen I and laminin-111 PMID: 17675292
Involvement in disease
Defects in COL1A1 are a cause of osteogenesis imperfecta (OI).
Subcellular Location
Secreted, extracellular space, extracellular matrix.
Protein Families
Fibrillar collagen family
Database Links
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Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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