Recombinant Drosophila melanogaster Centrosomin (cnn), partial

1. Drosophila centrosomin (cnn) expresses two major protein variants: the centrosomal form (CnnC) and a non-centrosomal form in testes (CnnT). CnnC is established as essential for functional centrosomes, the major MTOCs in animal cells. CnnT is expressed exclusively in testes and localizes to giant mitochondria in spermatids. PMID: 28669756
2. suggest an expanded model where during interphase CM2 interacts with pericentrin-like-protein to form a layer of centrosomin around the centriole wall and that at the onset of mitosis this population acts as a nucleation site of intramolecular centrosomin interactions that support the expansion into the metaphase matrix PMID: 29315319
3. Study shows that cnn exon1A-encoded proteins interact with Polo at 2 residues and that this interaction is required for polar body and pericentriolar matrix formation in syncytial embryos. PMID: 27096551
4. During pericentriolar matrix formation exon 1A Cnn-Long Form proteins likely bind Polo kinase before phosphorylation by Polo for Cnn transport to the centrosome. PMID: 26447129
5. The findings reveal that polarized targeting of Centrosomin to Golgi outposts during elaboration of the dendrite arbor creates a local system for guiding microtubule polymerization. PMID: 26322925
6. Cnn and PLP directly interact at two defined sites to coordinate the cell cycle-dependent rearrangement and scaffolding activity of the centrosome to permit normal centrosome organization, cell division, and embryonic viability. PMID: 26150390
7. Data suggest that centrioles can control the amount of pericentriolar material (PCM) they organize by regulating the rate of Cnn incorporation into the PCM. PMID: 21145741
8. Data suggest that centrosome size asymmetry in Drosophila neuroblasts is generated by the differential regulation of Cnn incorporation into the PCM at mother and daughter centrioles. PMID: 21145745
9. characterization of a new class of Cnn short isoforms required for centrosome function during gametogenesis and embryogenesis;evidence for a complex mix of Cnn isoforms present during early embryogenesis PMID: 19528326
10. centrosomes eject particles of centrosomin-containing pericentriolar material that move on dynamic astral microtubules at a rate that varies with the cell cycle PMID: 12415014
11. Results suggest that Aurora-A regulates centrosome assembly by controlling centrosomin's (CNN) ability to target and/or anchor gamma-tubulin to the centrosome and to organize microtubule-nucleating sites via interaction with CNN. PMID: 12939255
12. Cnn Motif 1 is necessary for proper recruitment of gamma-tubulin, D-TACC (the homolog of vertebrate transforming acidic coiled-coil proteins [TACC]), and Minispindles (Msps) to embryonic centrosomes PMID: 17671162
13. Data suggest that centrosomin maintains the proper connection between the centrioles and the pericentriolar matrix, which is required for accurate centriole segregation in somatic cells but is not essential for the asymmetric division of neuroblasts. PMID: 17709428

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KEGG: dme:Dmel_CG4832

STRING: 7227.FBpp0301625

UniGene: Dm.4773