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Recombinant Drosophila melanogaster Histone-lysine N-methyltransferase trr (trr), partial

Recombinant Drosophila melanogaster Histone-lysine N-methyltransferase trr (trr), partial

Code	CSB-YP818221DLU
MSDS	MSDS
Size	Pls inquire
Source	Yeast
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Code	CSB-EP818221DLU
MSDS	MSDS
Size	Pls inquire
Source	E.coli
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Code	CSB-EP818221DLU-B
MSDS	MSDS
Size	Pls inquire
Source	E.coli
Conjugate	Avi-tag Biotinylated E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code	CSB-BP818221DLU
MSDS	MSDS
Size	Pls inquire
Source	Baculovirus
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Code	CSB-MP818221DLU
MSDS	MSDS
Size	Pls inquire
Source	Mammalian cell
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

trr

Uniprot No.

Q8IRW8

Alternative Names

trr; KMT2C; CG3848Histone-lysine N-methyltransferase trr; EC 2.1.1.354; Lysine N-methyltransferase 2C; Trithorax-related protein

Species

Drosophila melanogaster (Fruit fly)

Protein Length

Partial

Tag Info

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer before Lyophilization

Tris/PBS-based buffer, 6% Trehalose, pH 8.0

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet

Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function

Histone methyltransferase that acts as a coactivator for the ecdysone receptor during development. Specifically trimethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation. Recruited by EcR in an ecdysone-dependent manner causing H3 'Lys-4' trimethylation at ecdysone-inducible promoters, leading to activate expression. Plays a central role in the developing compound eye, during the progression of the morphogenetic furrow and in post-furrow differentiation of the retinal epithelium, notably by activating expression of hh. Also required for wing and abdominal development.

Gene References into Functions

Histone H3K4 monomethylation catalyzed by Trr and mammalian MML3/MLL4 proteins at enhancers is dispensable for development and viability. PMID: 28967912
Ash2 functions together with Trr as an ecdysone receptor coactivator. PMID: 23197473
trr mutant cells have a growth advantage over their wild-type neighbors and display changes in the levels of multiple proteins that regulate growth and cell division, including Notch, Capicua, and cyclin B. PMID: 23459941
Trr, the Drosophila homolog of the mammalian Mll3/4 COMPASS-like complexes, can function as a major H3K4 monomethyltransferase on enhancers in vivo. PMID: 23166019
TRR is a histone methyltransferases capable of trimethylating lysine 4 of histone H3 (H3-K4); TRR possibly functions as a coactivator of ecdysone receptor by altering the chromatin structure at ecdysone-responsive promoters PMID: 14603321

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Subcellular Location

Nucleus. Chromosome.

Protein Families

Class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, TRX/MLL subfamily

Tissue Specificity

Widely expressed.

Database Links

KEGG: dme:Dmel_CG3848

STRING: 7227.FBpp0070347

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