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Recombinant Drosophila melanogaster Probable nuclear hormone receptor HR38 (Hr38), partial

Recombinant Drosophila melanogaster Probable nuclear hormone receptor HR38 (Hr38), partial

Code	CSB-YP344614DLU
MSDS	MSDS Datasheet
Size	Pls inquire
Source	Yeast
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Code	CSB-EP344614DLU
MSDS	MSDS Datasheet
Size	Pls inquire
Source	E.coli
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Code	CSB-EP344614DLU-B
MSDS	MSDS Datasheet
Size	Pls inquire
Source	E.coli
Conjugate	Avi-tag Biotinylated E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code	CSB-BP344614DLU
MSDS	MSDS Datasheet
Size	Pls inquire
Source	Baculovirus
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Code	CSB-MP344614DLU
MSDS	MSDS Datasheet
Size	Pls inquire
Source	Mammalian cell
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Hr38

Uniprot No.

P49869

Alternative Names

Hr38; NR4A4; CG1864; Probable nuclear hormone receptor HR38; dHR38; Nuclear receptor subfamily 4 group A member 4

Species

Drosophila melanogaster (Fruit fly)

Protein Length

Partial

Tag Info

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer before Lyophilization

Tris/PBS-based buffer, 6% Trehalose.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet

Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function

Binds to NGFI-B response elements. Plays an important role in late stages of epidermal metamorphosis.

Gene References into Functions

Hr38 was identified as a novel immediate early gene that is transiently expressed in the male silkmoth Bombyx mori by female odor stimulation. Hr38 was also used as a neural activity marker in the fly Drosophila melanogaster. PMID: 24120640
DHR38 might modulate the activity of the Usp-EcR heterodimer by forming complexes with both of its components PMID: 22628309
dHR38-N-Terminal domain exhibits a characteristic reminiscent of pre-molten globule-like intrinsically disordered proteins PMID: 21064127
Nutritional regulation of DHR38 expression maintains the proper uptake and storage of glycogen during the growing larval stage of development. PMID: 21084378
A second ecdysteroid signaling pathway is mediated by DHR38. DHR38 also heterodimerizes with Ultraspiralcle, and this complex responds to a distinct class of ecdysteroids in a manner that is independent of the ecdysteroid receptor. PMID: 12809604
Hr38 is a nuclear receptor which can assume an active conformation in the absence of a ligand agonist. PMID: 12852843
Gain and loss of function studies also implicate DHR38, the Drosophila homolog of vertebrate NGFI-B-type nuclear receptors, as an important activator of the ACP65A gene. PMID: 16106360
DHR38 may act as a positive regulator of neural Ddc expression PMID: 18059550
DHR38(Y214) mutants display minor effects on ecdysone-regulated transcription at the onset of metamorphosis PMID: 19235727

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Subcellular Location

Nucleus.

Protein Families

Nuclear hormone receptor family, NR4 subfamily

Tissue Specificity

Ubiquitously expressed in preblastoderm embryos, specifically in central nervous system and intestinal tract. Highly expressed in third instar larval imaginal disks and brain complexes, but not in ovaries.

Database Links

KEGG: dme:Dmel_CG1864

STRING: 7227.FBpp0080927

UniGene: Dm.2701

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