Recombinant Drosophila melanogaster RNA-binding protein cabeza (caz)

Code CSB-YP631662DLU
MSDS
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Source Yeast
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Code CSB-EP631662DLU
MSDS
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Source E.coli
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Code CSB-EP631662DLU-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP631662DLU
MSDS
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Source Baculovirus
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Code CSB-MP631662DLU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
caz
Uniprot No.
Alternative Names
caz; SARFH; CG3606RNA-binding protein cabeza; P19; Sarcoma-associated RNA-binding fly homolog
Species
Drosophila melanogaster (Fruit fly)
Expression Region
1-399
Target Protein Sequence
MERGGYGGGS GQGYNNFAVP PPNYQQMPNK TGNYNEPPPN YGKQGGGYDS GSGHRGSGGS GNGGGGGGSW NDRGGNSYGN GGASKDSYNK GHGGYSGGGG GGGGGGGGGS GGNDMITQED TIFVSGMDPS TTEQDIETHF GAIGIIKKDK RTMKPKIWLY KNKETGASKG EATVTYDDTN AAQSAIEWFD GRDFNGNAIK VSLAQRQNNW NKGGGGGGGG GGRGGFGGRR GGGGGGGGGG GGGGRFDRGG GGGGGRYDRG GGGGGGGGGG NVQPRDGDWK CNSCNNTNFA WRNECNRCKT PKGDDEGSSG GGGGGGYGGG GGGGGYDRGN DRGSGGGGYH NRDRGGNSQG GGGGGGGGGG YSRFNDNNGG GRGGRGGGGG NRRDGGPMRN DGGMRSRPY
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
May participate in a function common to the expression of most genes transcribed by RNA polymerase II.
Gene References into Functions
  1. Results that the molecular mechanisms controlling the nuclear import of FUS/Caz and FUS autoregulation are conserved between humans and Drosophila PMID: 25447237
  2. Data demonstrate that FUS/Caz regulates neuromuscular junction development and plays an evolutionarily conserved role in modulating the strength of synaptic transmission in motor neurons. PMID: 24569165
  3. The loss of caz in Drosophila led to severe growth defects in the eyes and ventral nerve cords, caused locomotive disability and neuromuscular junction disruption, but did not induce apoptotic cell death. PMID: 22443542
Subcellular Location
Nucleus.
Protein Families
RRM TET family
Tissue Specificity
Ubiquitous. Enriched in the brain and central nervous system during embryogenesis. Enriched in the adult head. Embryos contain both isoforms A and B, whereas later in development (heads and torsos) only isoform B is detected.
Database Links

KEGG: dme:Dmel_CG3606

STRING: 7227.FBpp0073996

UniGene: Dm.2872

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