Recombinant Drosophila melanogaster Target of rapamycin (Tor), partial

1. TORC1 is selectively activated in the second mitotic wave of the developing Drosophila eye. TORC1 is regulated by Hedgehog and E2F1 pathway. PMID: 28829944
2. TORC1 activity in the wing disc is patchy. TORC1 activity is high in cells at the G1/S transition due to CycD/Cdk4. PMID: 28829945
3. We show in vivo that autophagy is impaired in dGBA-deficient fly brains. In response, mechanistic target of rapamycin (mTOR) activity is downregulated in dGBA-deficient flies and rapamycin ameliorates the lifespan, locomotor, and oxidative stress phenotypes. dGBA knock-out flies also display an upregulation of the Drosophila ortholog of mammalian TFEB, Mitf, a response that is unable to overcome the autophagy block. Toget PMID: 27852774
4. To characterize natural genetic variation in the IIS/TOR pathway, we used >250 recombinant inbred lines (RILs) derived from a multiparental mapping population, the Drosophila Synthetic Population Resource, to map transcript-level QTL of genes encoding 52 core IIS/TOR components in three different nutritional environments PMID: 28592498
5. This study demonstrated that the absence of an engulfment receptor leads to a pronounced accumulation of dead neurons in the brain of the fruit fly and Rescued by TORC1 Activation. PMID: 26985028
6. evidence points to an ancient module comprising Mitf, v-ATPase and TORC1 that serves as a dynamic modulator of metabolism for cellular homeostasis. PMID: 26092939
7. Data show that genetic reduction in TOR Complex 1 (TORC1) signalling improves the impaired motor performance phenotype of Friedreich's ataxia (FRDA) model flies. PMID: 26158631
8. Loss of TORC2 disrupted the nuclear localization of Myc, and inhibited Myc-dependent transcription. PMID: 25999153
9. We show that changing the proportion of t(6)A-modified tRNAi (Met), by expression of an un-modifiable tRNAi (Met) or changing the levels of Tcs3, regulate target of rapamycin (TOR) kinase activity and influences cell and animal growth in vivo. PMID: 26063805
10. lowered dietary amino acids promote longevity via TOR PMID: 24861087
11. nutrient sensing through the Insulin/IGF and TOR pathways couples cuticle pigmentation of both male and female Drosophila with their nutritional status during metamorphosis. PMID: 24133012
12. our observation established that Spargel/dPGC-1 is indeed a terminal effector in the insulin-TOR pathway operating below TOR, S6K, Tsc, and FoxO PMID: 23934892
13. Tor and InR are required cell-autonomously for the proliferation of precursors for both somatic niches and germline stem cells. PMID: 24026119
14. DREF is required for growth downstream of TOR, but not insulin/PI3K signaling. PMID: 22960233
15. Target of rapamycin (Tor) mutants did show a phenotype that mimicked WT starvation-induced PCD, indicating an insulin independent regulation of PCD via Tor signaling. PMID: 22240900
16. Loss of postsynaptic TOR disrupts a retrograde compensatory enhancement in neurotransmitter release that is normally triggered by a reduction in postsynaptic glutamate receptor activity. PMID: 22500638
17. Cellular detoxification pathways, increased autophagy and altered protein synthesis have all been implicated in increased lifespan from reduced IIS/TOR activity, with the role of defence against oxidative stress unresolved PMID: 20849947
18. we review the contribution of the model organism Drosophila in the understanding of TOR signaling and the various biological processes it modulates that may impact on aging PMID: 21130151
19. TORC1-S6K-RPS6 (as a fusion protein)signaling axis is regulated by many subcellular components, including the Class I vesicle coat (COPI), the spliceosome, the proteasome, the nuclear pore, and the translation initiation machinery. PMID: 21239477
20. These results uncover specific TOR functions in the control of stem cells versus their differentiating progeny, and reveal parallels between Drosophila and mammalian follicle growth. PMID: 20504961
21. analysis of Dendritic tiling through TOR signalling PMID: 20010972
22. Rheb functions in the insulin signaling pathway upstream of TOR. PMID: 12766776
23. Loss of Tsc1 and Tsc2 or ectopic activation of Rheb results in constitutive activation of TOR and renders S6K activity resistant to amino acid starvation. PMID: 12771962
24. results suggest that dTOR and dRictor have a shared positive role in the phosphorylation of the hydrophobic motif site of dAkt/dPKB PMID: 15718470
25. tap42 functions independently of target of rapamycin to regulate cell division and survival in Drosophila PMID: 15802506
26. TOR-mediated cell-cycle activation causes neurodegeneration in a Drosophila tauopathy model, identifying TOR and the cell cycle as potential therapeutic targets in tauopathies and Alzheimer Disease. PMID: 16461276
27. Endocytosis acts both as an effector function downstream of TOR and as a physiologically relevant regulator of TOR signaling. PMID: 16785324
28. Here, they show that reducing the function of Drosophila TOR results in decreased lipid stores and glucose levels. PMID: 16890541
29. Results show that mildly increasing systemic Rheb-TOR-S6K signaling sensitizes the whole organism to oxidative stress and promotes senescence of locomotor activity with age. PMID: 17038544
30. Rheb-TOR signaling controls S2 cell growth by promoting ribosome production and protein synthesis, not by direct effects on the import of amino acids or glucose. The effect of insulin signaling upon TOR activity varies by cellular type and context. PMID: 17371599
31. Results show that the effects of TOR on growth and metabolism was mediated by Myc. PMID: 18177722
32. a function of Rag GTPases in TORC1 activation in response to amino acid signals PMID: 18604198
33. The Tor pathway couples nutrition and developmental timing in Drosophila. PMID: 18854141
34. Studies show the increasingly prominent links between TOR signaling and aging in invertebrates. PMID: 19539012
35. up-regulation of dEif4e is sufficient to recapitulate the effects of high dTOR or insulin signaling in cardiac aging in Drosophila. PMID: 19594484
36. Data indicate that TOR induces cell death by suppressing autophagy and provide direct genetic evidence that autophagy alleviates cell death in several common types of neurodegenerative disease. PMID: 19720874

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KEGG: dme:Dmel_CG5092

STRING: 7227.FBpp0080003

UniGene: Dm.1502