Product Details

Purity

>85% (SDS-PAGE)

Target Names

Abl

Uniprot No.

P00522

Alternative Names

Abl; ABL-1; Dash; CG4032Tyrosine-protein kinase Abl; EC 2.7.10.2; D-ash; Protein abelson

Species

Drosophila melanogaster (Fruit fly)

Protein Length

Partial

Tag Info

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer before Lyophilization

Tris/PBS-based buffer, 6% Trehalose.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet

Please contact us to get it.

Target Background

Function

Arm and Abl proteins function cooperatively at adherens junctions in both the CNS and epidermis; critical for embryonic epithelial morphogenesis regulating cell shape changes and cell migration. Plays a critical role in transducing embryonic midline repulsive cues; may regulate cytoskeletal dynamics underlying a growth cone's response to midline cues. The ability of pCC/MP2 axons to correctly interpret midline repulsive cues and stay on the ipsilateral side is dependent on the strength of both Slit/robo and Abl-dependent signaling pathways.

Gene References into Functions

Abl is an essential regulator for myocyte. PMID: 24466097
Abl plays a role in the organization of filamentous actin and the redistribution of the junctional protein beta-catenin at the wound margin during embryonic wound repair. PMID: 24948602
Abl is required for photoreceptor cell fate maintenance, as Abl mutant photoreceptors lose neuronal markers during late pupal stages but do not re-enter a proliferative state or undergo apoptosis. PMID: 23175629
Results reveal a prominent role for Abl in coordinating multiple aspects of photoreceptor morphogenesis. PMID: 21674685
The main upstream stimulus activating the c-Abl/p73 pathway and neuronal apoptosis in Niemann-Pick type C neurons is oxidative stress. PMID: 20883783
Dab is a bona fide component of Abl signaling in Drosophila. PMID: 20940230
Mutated c-Abl stimulated the formation of F-actin branches in neurites of rat embryonic cortical neurons. The reciprocal regulation between F-actin and the c-Abl tyrosine kinase may provide a mechanism for control of actin cytoskeleton dynamics PMID: 11864995
In Abl's absence, excess actin is polymerized in apical microvilli, whereas too little actin is assembled into pseudocleavage and cellularization furrows. PMID: 14676307
a reduction in Abl gene dosage causes distal paralysis and axonal swellings PMID: 15975902
Abl acts apically to suppress the accumulation of both Enabled (Ena) and actin in mesodermal cells during ventral furrow formation PMID: 17202187
These data provide new insight into how regulated Abl activity helps direct normal development and into possible biological functions of Bcr-Abl. PMID: 17959833

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Subcellular Location

Cytoplasm.

Protein Families

Protein kinase superfamily, Tyr protein kinase family, ABL subfamily

Tissue Specificity

Arm and ena colocalize with Abl at adherens junctions throughout development.

Database Links

KEGG: dme:Dmel_CG4032

STRING: 7227.FBpp0303166

UniGene: Dm.5397

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Recombinant Drosophila melanogaster Tyrosine-protein kinase Abl (Abl), partial

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