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Abl Antibody

Datasheet
Code CSB-PA355528XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) Abl Polyclonal antibody
Uniprot No.
P00522
Target Names
Abl
Alternative Names
Abl antibody; ABL-1 antibody; Dash antibody; CG4032Tyrosine-protein kinase Abl antibody; EC 2.7.10.2 antibody; D-ash antibody; Protein abelson antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) Abl protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
ELISA Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Abl Proteins

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Target Background

Function
Arm and Abl proteins function cooperatively at adherens junctions in both the CNS and epidermis; critical for embryonic epithelial morphogenesis regulating cell shape changes and cell migration. Plays a critical role in transducing embryonic midline repulsive cues; may regulate cytoskeletal dynamics underlying a growth cone's response to midline cues. The ability of pCC/MP2 axons to correctly interpret midline repulsive cues and stay on the ipsilateral side is dependent on the strength of both Slit/robo and Abl-dependent signaling pathways.
Gene References into Functions
  1. Abl is an essential regulator for myocyte. PMID: 24466097
  2. Abl plays a role in the organization of filamentous actin and the redistribution of the junctional protein beta-catenin at the wound margin during embryonic wound repair. PMID: 24948602
  3. Abl is required for photoreceptor cell fate maintenance, as Abl mutant photoreceptors lose neuronal markers during late pupal stages but do not re-enter a proliferative state or undergo apoptosis. PMID: 23175629
  4. Results reveal a prominent role for Abl in coordinating multiple aspects of photoreceptor morphogenesis. PMID: 21674685
  5. The main upstream stimulus activating the c-Abl/p73 pathway and neuronal apoptosis in Niemann-Pick type C neurons is oxidative stress. PMID: 20883783
  6. Dab is a bona fide component of Abl signaling in Drosophila. PMID: 20940230
  7. Mutated c-Abl stimulated the formation of F-actin branches in neurites of rat embryonic cortical neurons. The reciprocal regulation between F-actin and the c-Abl tyrosine kinase may provide a mechanism for control of actin cytoskeleton dynamics PMID: 11864995
  8. In Abl's absence, excess actin is polymerized in apical microvilli, whereas too little actin is assembled into pseudocleavage and cellularization furrows. PMID: 14676307
  9. a reduction in Abl gene dosage causes distal paralysis and axonal swellings PMID: 15975902
  10. Abl acts apically to suppress the accumulation of both Enabled (Ena) and actin in mesodermal cells during ventral furrow formation PMID: 17202187
  11. These data provide new insight into how regulated Abl activity helps direct normal development and into possible biological functions of Bcr-Abl. PMID: 17959833

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Subcellular Location
Cytoplasm.
Protein Families
Protein kinase superfamily, Tyr protein kinase family, ABL subfamily
Tissue Specificity
Arm and ena colocalize with Abl at adherens junctions throughout development.
Database Links

KEGG: dme:Dmel_CG4032

STRING: 7227.FBpp0303166

UniGene: Dm.5397

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