Recombinant Epstein-Barr virus Epstein-Barr nuclear antigen 2 (EBNA2), partial

1. Identified three independent domains within EBNA2 that act through species-specific mechanisms. Importantly, the EBNA2 orthologues and species-specific EBNA2 domains separate unique roles for EBNA2 in the initiation of B cell immortalization from those responsible for maintaining the immortalized state. PMID: 29261800
2. This study identifies the BS69 C-terminal domains as an inhibitor of EBNA2. PMID: 26845565
3. Authors show that human herpesvirus 4 EBNA2 represses BIK in B-cell lymphoma-derived cell lines and that this host-virus interaction can inhibit the proapoptotic effect of transforming growth factor beta1. PMID: 24554662
4. PRMT5 triggers the symmetric dimethylation of EBNA2 RG domain to coordinate with EBNA2-mediated transcription. PMID: 23261437
5. present data suggest that EBNA2 might contribute to EBV-induced B-cell transformation by increasing oncomiR-like miR-21 and by affecting the antiviral responses of the innate immune system through downregulation of its key regulator miR-146a PMID: 22614176
6. The subtypes E2-A and E2-C were the dominant genotypes of the EBNA-2 gene in nasopharyngeal and gastric carcinomas. PMID: 22348267
7. mechanism by which the PhiW PhiP motif of RAM and EBNA2 compete with one another for binding at the hydrophobic pocket of the beta-trefoil domain (BTD) of CSL using overlapping but specific interactions that are unique to each BTD ligand. PMID: 20028974
8. Inhibition of methylation in EBV-infected cells results in reduced expression of the EBNA2-regulated viral gene LMP1, evidencing that methylation is a prerequisite for DNA-binding by EBNA2 via association with the transcription factor RBPJkappa. PMID: 19969318
9. data implicate EBNA2 Ser243 as a cdc2/cyclin B1 site of phosphorylation important for EBNA2's cotranscriptional function in mitosis PMID: 16439560
10. results identify FcRH5 as a novel, direct target of EBNA2 that may contribute to the development of Epstein-Barr virus-associated tumors (Epstein-Barr virus nuclear antigen 2) PMID: 16439682
11. EBNA2 trans-activates bfl-1, which requires CBF1 (or RBP-J kappa). PMID: 16873269
12. p55alpha is thus a functional target of EBNA2 in EREB2.5 cells PMID: 16963743
13. broad spectrum of EBNA-2 functions involved in virus-host interactions, including cell signaling molecules, adapters, genes involved in cell cycle regulation, and chemokines PMID: 16973580
14. In EBV-negative diffuse large B-cell lymphoma and Burkitt lymphoma-derived cell lines infected in vitro with a recombinant EBV, high expression of EBNA2 inversely correlated with expression of germinal center-associated genes, BCL6 and TCL1. PMID: 17151114
15. results indicate that differential gene regulation by Epstein-Barr virus type 1 and type 2 EBNA2 may be the basis for the much weaker B-cell transformation activity of type 2 Epstein-Barr virus strains compared to type 1 strains. PMID: 18480445
16. EBNA2 is a transcriptional coactivator of STAT3 by influencing its DNA-binding activity. PMID: 19032945
17. EBNA2 was shown to be able to downregulate mitotic arrest deficient 2 (MAD2) approximately 2- to 3-fold and upregulate polo-like kinase 1 (PLK1) approximately 2-fold. PMID: 19126642
18. Both EBNA2 and Notch-IC induced the expression of proapoptotic genes, but only in EBNA2-expressing cells were antiapoptotic genes strongly up-regulated. PMID: 19339697

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KEGG: vg:3783761