Recombinant Helicobacter pylori Urease subunit beta (ureB)

The recombinant H. pylori ureB protein is encoded by the gene of ureB (1-569aa). The gene of ureB was cloned in a system (E.coli) that supported the expression of ureB and translation of messenger RNA. Modification of ureB by recombinant DNA technology could lead to the expression of the target protein. The protein was fused with N-terminal 6xHis tag in the production. The purity is 90% determined by SDS-PAGE.

UreB is a protein coding gene that encodes Urease subunit beta. According to some studies, UreB may have the following features.
The ureA and ureB genes encoding H. pylori urease are transcribed and translated in E. coli, and these genes alone are sufficient to synthesize and assemble the bulk-sized enzyme. The basic properties of H. pylori urease activity on colonization indicate that H. pylori urease is an excellent reporter of gene expression in H. pylori. Recombinant L. lactis expressing UreB-IL-2 has the potential to be used as an edible vaccine for the control of Helicobacter pylori infection. UreB transgenic carrots have the potential to be used as an edible vaccine for the control of Helicobacter pylori. UreB enhances the stability of UreC against proteolysis.