Recombinant Human 5,6-dihydroxyindole-2-carboxylic acid oxidase (TYRP1), partial,Baculovirus

Code CSB-BP025399HU1
Size
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
TYRP1
Uniprot No.
Alternative Names
TYRP1; CAS2; TYRP; TYRRP; 5,6-dihydroxyindole-2-carboxylic acid oxidase; DHICA oxidase; Catalase B; Glycoprotein 75; Melanoma antigen gp75; Tyrosinase-related protein 1; TRP; TRP-1; TRP1
Species
Homo sapiens (Human)
Source
Baculovirus
Protein Length
Partial
Tag Info
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
Form
Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer
If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Plays a role in melanin biosynthesis. Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid in the presence of bound Cu(2+) ions, but not in the presence of Zn(2+). May regulate or influence the type of melanin synthesized. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin.
Gene References into Functions
  1. The rs387907171 SNP in TYRP1 exhibits strong allele frequency differences among islands in Northern Island Melanesia. Its absence from Bougainville, as well as the weak association with decreased hair color, indicates that additional alleles contribute to the blondism phenotype. PMID: 26450459
  2. TYRP1-dependent miR-16 sequestration can also be overcome in vivo by using small oligonucleotides that mask miR-16-binding sites on TYRP1 mRNA. PMID: 28991221
  3. The mRNA of TYRP1 is now found to sequester the tumour suppressor miR-16. PMID: 29087386
  4. DNA sequencing showed that the patient has carried compound heterozygous mutations of the tyrosinase related protein (TYRP1) gene, namely c.1214C>A (p.T405N) and c.1333dupG, which were inherited from his mother and father, respectively. PMID: 28186599
  5. Single nucleotide polymorphisms in TYRP1 gene is associated with multiple primary melanoma. PMID: 25837821
  6. Mutation in TYRP1 is associated with oculocutaneous albinism. PMID: 26252096
  7. Polymorphisms in 3'UTR of TYRP1 mRNA can affect TYRP1 mRNA regulation by miR-155 and its subsequent translation into protein. These SNPs can render TYRP1 mRNA and protein expression nonsusceptible to miR-155 activity PMID: 26068396
  8. These data suggest that UVB-stimulated Ucn1 contributes to TRP1 production via the transcription of both Nurr-1 and Nur77. Ucn1, produced in melanoma cells, acts on melanoma cells themselves in an autocrine manner. PMID: 25240771
  9. These data indicate that galectin-3 is a regulatory component in melanin synthesis affecting the expression of Tyrp-1. PMID: 25054620
  10. p53 regulation by TRP2 is not pervasive in melanoma. PMID: 24475287
  11. Due to mutation in Tyrp1 protein, it became more rigid and might disturb the structural conformation and catalytic function of the structure and might also play a significant role in inducing oculocutaneous albinism type III. PMID: 23862152
  12. in human melanoma HMV-II cells both CRF and Ucn1 regulate TRP1 gene expression via Nurr-1/Nur77 production, independent of pro-opiomelanocortin or alpha-melanocyte-stimulating hormone stimulation. PMID: 23416839
  13. High TYRP1/S100B mRNA expression in lymph node metastases from melanoma patients is associated with unfavourable clinical outcome. PMID: 23519055
  14. We report four Pakistani albinism mutations, including three SLC45A2 alleles and one 22-nucleotide deletion in TYRP1. PMID: 23190901
  15. identifed an arginine-to-cysteine change at a highly conserved residue in TYRP1 as a major determinant of blond hair in Solomon Islanders; this missense mutation predicted to affect catalytic activity of TYRP1 and causes blond hair through a recessive mode of inheritance PMID: 22556244
  16. We used the first ranked gene, tyrosinase-related protein 1 (TYRP1), further measured its expression in the validation population by real-time PCR and found it to be significantly correlated with distant metastasis-free survival. PMID: 22045183
  17. two novel mutations in TYRP1 gene in two Chinese patients with oculocutaneous albinism type 3 PMID: 21739261
  18. Case Report: Report a Japanese girl with oculocutaneous albinism type 3 and novel mutations in TYRP1 gene. PMID: 21996312
  19. This review focuses on TYRP1, a melanosomal protein involved in the pigmentary machinery of the melanocyte and often used as differentiation marker, with a special emphasis on its emerging roles in the malignant melanocyte and melanoma progression. PMID: 21324755
  20. interactions between TRP1-GIPC and GIPC-APPL-AKT provide a potential link between melanogenesis and PI3 kinase signaling PMID: 21291857
  21. Adoptive transfer of TRP1-specific T cells into -expressing recipients produces large confluent patches of vitiligo and ocular damage in TRP1-specific T cell receptor transgenic mice. PMID: 20668223
  22. Tyrp1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. Tyrp1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and melanocyte cell death. PMID: 11775055
  23. DNA sequence variants in the human TYRP1 gene are not associated with inherited pigmentary glaucoma in humans. PMID: 12011806
  24. We have identified the first TYRP1 mutation in non-Africans and have confirmed that TYRP1 mutations are associated with a milder phenotype of oculocutaneous albinism. PMID: 15996218
  25. The presence of a distal Tyrp1 regulatory element, which specifies melanocyte-specific expression, supports the idea that separate regulatory sequences can mediate differential gene expression in melanocytes and RPE. PMID: 16934245
  26. Melanocytes in vitiligo demonstrate reduced ability to withstand oxidative stress due, partly, to a disruption in microphthalmia-associated transcription factor regulation of Tyrp1. PMID: 17071589
  27. We observe strong evidence for positive selection for TYRP1 alleles in Africans and in Asians PMID: 18312627
  28. An eye color variant in TYRP1 was associated with risk of cutaneous melanoma. PMID: 18488027
  29. Mutation of TYRP1 (OCA3) can modify the OCA2 phenotype, resulting in red hair. PMID: 18680187
  30. Both TRP-1 and galectin-1 were highly expressed in normal melanocytes and melanoma. There was no correlation between TRP-1 or galectin-1 expression and survival. PMID: 19287070
  31. TYRP1 rs1408799 is associated with melanoma. PMID: 19384953

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Involvement in disease
Albinism, oculocutaneous, 3 (OCA3)
Subcellular Location
Melanosome membrane; Single-pass type I membrane protein. Melanosome.
Protein Families
Tyrosinase family
Tissue Specificity
Pigment cells.
Database Links

HGNC: 12450

OMIM: 115501

KEGG: hsa:7306

STRING: 9606.ENSP00000373570

UniGene: Hs.270279

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