Product Details

Purity

Greater than 95% as determined by SDS-PAGE.

Activity

Not Test

Target Names

ADAMTS12

Uniprot No.

P58397

Research Area

Cell Biology

Alternative Names

ADAM-TS 12; ADAM-TS12; ADAMTS-12;ADAMTS12;UNQ1918/PRO4389

Species

Homo sapiens (Human)

Source

E.coli

Expression Region

246-544aa

Target Protein Sequence

RWVETLVVADTKMIEYHGSENVESYILTIMNMVTGLFHNPSIGNAIHIVVVRLILLEEEEQGLKIVHHAEKTLSSFCKWQKSINPKSDLNPVHHDVAVLLTRKDICAGFNRPCETLGLSHLSGMCQPHRSCNINEDSGLPLAFTIAHELGHSFGIQHDGKENDCEPVGRHPYIMSRQLQYDPTPLTWSKCSEEYITRFLDRGWGFCLDDIPKKKGLKSKVIAPGVIYDVHHQCQLQYGPNATFCQEVENVCQTLWCSVKGFCRSKLDAAADGTQCGEKKWCMAGKCITVGKKPESIPGG
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Mol. Weight

40.4 kDa

Protein Length

Partial

Tag Info

C-terminal 6xHis-tagged

Form

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Basically, we can dispatch the products out in 3-7 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Datasheet & COA

Please contact us to get it.

Target Background

Function

Metalloprotease that may play a role in the degradation of COMP. Cleaves also alpha-2 macroglobulin and aggregan. Has anti-tumorigenic properties.

Gene References into Functions

ADAMTS 1, 4, 12, and 13 levels in the maternal and cord blood were lower in the preeclampsia group than in the control group. ADAMTS 1, 4, and 12 levels in placental tissues were higher in the preeclampsia group. PMID: 29135310
ADAMTS12 expression is significantly upregulated in human masticatory mucosa during wound healing PMID: 28005267
Decreased levels of ADAMTS-12 were found to be associated with intrahepatic cholestasis of pregnancy. PMID: 26363034
ADAMTS-12 is a multifaced metalloproteinase in arthritis and inflammation [review] PMID: 24876675
ADAMTS-12 is implicated in the inflammatory response by modulating normal neutrophil apoptosis. PMID: 23019333
Our results suggest that ADAMTS12 may be a susceptibility gene for RA development. PMID: 22505177
statistically significant increase in mRNA expression of ADAMTS-7 and ADAMTS-12 was observed in the endplate cells in degenerative discs compared with nondegenerative discs PMID: 22247065
The data supported the hypothesis that genetic variations in ADAMTS12 influence the risk of schizophrenia. PMID: 22322903
expression of ADAMTS12 in colorectal cancer stroma plays an important role in inhibiting tumor development PMID: 21559743
This study identifies a novel biological role for ADAMTS-12, and highlights the importance and complexity of its non-proteolytic domain(s) pertaining to its function. PMID: 21494557
ADAMTS-12 is a new COMP-interacting and -degrading enzyme and thus may play an important role in the COMP degradation in the initiation and progression of arthritis PMID: 16611630
data suggest that ADAMTS12 confers tumour-protective functions upon cells that produce this proteolytic enzyme PMID: 17895370
ADAMTS-7 and ADAMTS-12 are newly identified enzymes responsible for cartilage oligomeric matrix protein degradation in arthritis. PMID: 19098927
Results demonstrate that ADAMTS-12, a downstream molecule of PTHrP signaling, is a novel regulator of chondrogenesis. PMID: 19151918
ADAMTS-12 is a novel anti-tumor protease that can reduce the proliferative properties of tumor cells. PMID: 19638407

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Subcellular Location

Secreted, extracellular space, extracellular matrix.

Tissue Specificity

Expressed in skeletal muscle and fat.

Database Links

HGNC: 14605

OMIM: 606184

KEGG: hsa:81792

STRING: 9606.ENSP00000422554

UniGene: Hs.12680

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Code	CSB-EP001300HU
Abbreviation	Recombinant Human ADAMTS12 protein, partial
MSDS	MSDS Datasheet
Size	$306
	Order now
Image	(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Recombinant Human A disintegrin and metalloproteinase with thrombospondin motifs 12 (ADAMTS12), partial

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