Recombinant Human ATP-binding cassette sub-family A member 5(ABCA5) ,partial

Code CSB-YP845163HU
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Source Yeast
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Code CSB-EP845163HU
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Source E.coli
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Code CSB-EP845163HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP845163HU
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Source Baculovirus
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Code CSB-MP845163HU
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names ABCA5
Uniprot No. Q8WWZ7
Alternative Names ABC13; ABCA5; ABCA5_HUMAN; ATP binding cassette sub family A (ABC1) member 5; ATP binding cassette A5; ATP binding cassette sub family A member 5; ATP-binding cassette sub-family A member 5; DKFZp451F117; DKFZp779N2435; EST90625; FLJ16381; KIAA1888
Species Homo sapiens (Human)
Protein Length Partial
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
Cholesterol efflux transporter in macrophages that is responsible for APOAI/high-density lipoproteins (HDL) formation at the plasma membrane under high cholesterol levels and participates in reverse cholesterol transport. May play a role in the processing of autolysosomes.
Gene References into Functions
  1. This report represents the first extensive expression and functional study of ABCA5 in the human brain and our data suggest a plausible function of ABCA5 in the brain as a cholesterol transporter associated with Abeta generation PMID: 25125465
  2. our findings support ABCA5 as a gene underlying the congenital generalized hypertrichosis terminalis phenotype and suggest a novel, previously unrecognized role for this gene in regulating hair growth. PMID: 24831815
  3. The expression of ABCA5 was significantly elevated in parkinson disease brains compared to age- and gender-matched control brains. PMID: 23939407
  4. The ABCB5 gene may be related to the properties of chemoresistance and aggressiveness of melanoma PMID: 20487690
  5. Cloning of ABCA5 and detection of a splice variant. PMID: 12504089
  6. ABCA5 may have a role in prostatic intraepithelial neoplasia PMID: 17289887
  7. There is a correlation of induction of ABCA5 and mRNA with differentiation of colonic neoplasms. PMID: 17541169

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Subcellular Location Golgi apparatus membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Cell membrane.
Protein Families ABC transporter superfamily, ABCA family
Tissue Specificity Ubiquitously expressed. Highly expressed in testis, skeletal muscle, kidney, liver and placenta. Expressed in both the epithelial and mesenchymal compartments, present within the outer root sheath (ORS) of the hair follicle as well as dermal sheath. Expre
Database Links

HGNC: 35

OMIM: 612503

KEGG: hsa:23461

STRING: 9606.ENSP00000376443

UniGene: Hs.731824

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