Recombinant Human Acyl-coenzyme A synthetase ACSM3, mitochondrial (ACSM3)

Code CSB-YP709601HU
MSDS
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Source Yeast
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Code CSB-EP709601HU
MSDS
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Source E.coli
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Code CSB-EP709601HU-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP709601HU
MSDS
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Source Baculovirus
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Code CSB-MP709601HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
ACSM3
Uniprot No.
Alternative Names
ACSM3; ACSM3_HUMAN; Acyl CoA synthetase medium chain family member 3; Acyl-CoA synthetase medium-chain family member 3; Acyl-coenzyme A synthetase ACSM3; Acyl-coenzyme A synthetase ACSM3; mitochondrial; Butyrate CoA ligase 3; Butyrate--CoA ligase 3; Butyryl coenzyme A synthetase 3; Butyryl-coenzyme A synthetase 3; Middle chain acyl CoA synthetase 3; Middle-chain acyl-CoA synthetase 3; mitochondrial; Protein SA homolog; SA (rat hypertension associated) homolog; SA; SA hypertension associated homolog; SA; rat; homolog of; SAH
Species
Homo sapiens (Human)
Expression Region
28-586
Target Protein Sequence
LHK DNRTATPQNF SNYESMKQDF KLGIPEYFNF AKDVLDQWTD KEKAGKKPSN PAFWWINRNG EEMRWSFEEL GSLSRKFANI LSEACSLQRG DRVILILPRV PEWWLANVAC LRTGTVLIPG TTQLTQKDIL YRLQSSKANC IITNDVLAPA VDAVASKCEN LHSKLIVSEN SREGWGNLKE LMKHASDSHT CVKTKHNEIM AIFFTSGTSG YPKMTAHTHS SFGLGLSVNG RFWLDLTPSD VMWNTSDTGW AKSAWSSVFS PWIQGACVFT HHLPRFEPTS ILQTLSKYPI TVFCSAPTVY RMLVQNDITS YKFKSLKHCV SAGEPITPDV TEKWRNKTGL DIYEGYGQTE TVLICGNFKG MKIKPGSMGK PSPAFDVKIV DVNGNVLPPG QEGDIGIQVL PNRPFGLFTH YVDNPSKTAS TLRGNFYITG DRGYMDKDGY FWFVARADDV ILSSGYRIGP FEVENALNEH PSVAESAVVS SPDPIRGEVV KAFVVLNPDY KSHDQEQLIK EIQEHVKKTT APYKYPRKVE FIQELPKTIS GKTKRNELRK KEWKTI
Protein Length
Full Length of Mature Protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism. Capable of activating medium-chain fatty acids with a preference for isobutyrate among fatty acids with 2-6 carbon atoms.
Gene References into Functions
  1. Our data provide evidence for a differential expression and regulation of the ACSM3 gene in hepatocellular carcinoma PMID: 28390038
  2. Reduced ACSM3 is associated with impaired butyrate oxidation in ulcerative colitis. PMID: 21987487
  3. SA gene polymorphism may be associated with the renal prognosis of immunoglobulin A nephropathy through its effect on blood pressure. Sensitivity to this gene polymorphism increases in patients with renal injury. PMID: 12484505
  4. variation in SAH has a role in predisposition to overweight in hypertensives. PMID: 14567496
  5. confirms recent evidence that the SAH locus is associated with obesity-related hypertension PMID: 17278971
  6. family-based analyses of SA hypertension-associated homolog (SAH) gene variants did not reveal population stratification supporting an association of hypertension and gene variants PMID: 18192838
  7. We conclude that, in spite of its renal expression,1-3 the human SAH gene is unlikely to have an important role in renal sodium handling. PMID: 18519841
  8. SA hypertension-associated homolog(SAH) gene polymorphisms are associated with non-high-density lipoprotein cholesterol in postmenopausal women PMID: 19108963
  9. left ventricular mass index and mean wall thickness , two phenotypes that are jointly influenced by blood pressure and obesity, might be related to variation in the human SAH gene PMID: 19262474

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Subcellular Location
Mitochondrion. Mitochondrion matrix.
Protein Families
ATP-dependent AMP-binding enzyme family
Database Links

HGNC: 10522

OMIM: 145505

KEGG: hsa:6296

STRING: 9606.ENSP00000289416

UniGene: Hs.706754

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