Recombinant Human Acylglycerol kinase, mitochondrial (AGK)

1. The dual function of AGK as lipid kinase and constituent of the TIM22 complex reveals that disturbances in both phospholipid metabolism and mitochondrial protein biogenesis contribute to the pathogenesis of Sengers syndrome. PMID: 28712724
2. Identify AGK as a bona fide subunit of TIM22 providing an exciting and unexpected link between mitochondrial protein import and Sengers syndrome. PMID: 28712726
3. Acylglycerol kinase functions as an oncogene and an unfavorable prognostic marker for human gliomas. PMID: 27574811
4. We showed that AGK was over-expressed in cervical cancer cell lines and clinical tissues, and over-expression of AGK was associated with poor survival outcomes of early-stage CSCC patients. AGK can be used as an independent prognostic marker for early-stage CSCC. PMID: 26662108
5. Data suggest that acylglycerol kinase (AGK) has potential as a prognostic factor for overall survival in nasopharyngeal carcinoma (NPC). PMID: 26443540
6. AGK promotes the proliferation and cell cycle progression of oral squamous cell carcinoma. PMID: 25872568
7. miR-194 could reduce the phosphoinositide 3-kinase (PI3K)/AKT/FoxO3a signaling pathway by suppressing acylglycerol kinase (AGK) directly. PMID: 25960215
8. findings provide new evidence that AGK plays an important role in promoting angiogenesis and providing resistance to apoptosis in hepatocellular carcinoma PMID: 25474138
9. compare our findings to those in 21 previously reported AGK mutation-positive Sengers patients, confirming that Sengers syndrome is a clinically recognisable disorder of mitochondrial energy metabolism PMID: 25208612
10. AGK promotes cell proliferation and tumorigenicity in breast cancer via suppression of the FOXO1. PMID: 24886245
11. Our findings suggest that ATX-AGK-LPA signaling axis might be an important player in the development and progression of diabetic retinopathy. PMID: 22864860
12. AGK expression was significantly correlated with JAK2/STAT3 hyperactivation in esophageal squamous cell carcinoma, as well as in lung and breast cancer. PMID: 23676499
13. study reports 2 families with Sengers syndrome and mutations in the acylglycerol kinase gene; 1 proband had abnormal mitochondria with citrate synthase crystals, associated with high citrate synthase activity; these pedigrees confirm that mutation of AGK is responsible for the severe neonatal presentation of Sengers syndrome PMID: 23266196
14. This is the first mutation in AGK gene to be implicated in the development of isolated cataract. PMID: 22415731
15. The loss of AGK led to a decrease of the adenine nucleotide translocator in the inner mitochondrial membrane in muscle. PMID: 22284826
16. Recessive mutations in AGK cause mitochondrial DNA depletion PMID: 22277967
17. Lack of the AGK causes Sengers syndrome PMID: 22284826
18. identification and characterization of a novel lipid kinase that phosphorylates multiple substrates, MuLK PMID: 15252046
19. The chiral specificity of diacylglycerol kinase alpha, zeta & epsilon mimics the substrate specificity, with MuLK being the least selective and the epsilon isoform of diacylglycerol kinase exhibiting the greatest selectivity. PMID: 18004883
20. High Expression of acylglycerol kinase is associated with development and progression of prostate cancer. PMID: 19549252

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HGNC: 21869

OMIM: 212350

KEGG: hsa:55750

STRING: 9606.ENSP00000347581

UniGene: Hs.743318