Recombinant Human Adipolin (C1QTNF12)

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Code CSB-EP713130HU
Size $388
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  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Product Details

Greater than 95% as determined by SDS-PAGE.
Not Test
Target Names
Uniprot No.
Research Area
Alternative Names
Adipose-derived insulin-sensitizing factor;C1q and TNF related protein 12;Complement C1q tumor necrosis factor-related protein 12;Adipolin fCTRP12;Adipolin full-length form;Adipolin cleaved form;Adipolin gCTRP12
Homo sapiens (Human)
Expression Region
Target Protein Sequence
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
Mol. Weight
36.1 kDa
Protein Length
Full Length of Mature Protein
Tag Info
N-terminal 6xHis-tagged
Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
3-7 business days
Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Datasheet & COA
Please contact us to get it.

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Target Background

Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses de novo glucose production in hepatocytes via the PI3K-Akt signaling pathway. Administration lead to reduction of blood glucose. Able to attenuate inflammation in fat tissue.
Gene References into Functions
  1. Adipolin and adiponectin are cytokines that exert substantial impact on obesity, progression of atherosclerosis, insulin resistance, and glucose metabolism. PMID: 29452073
  2. Low serum CTRP12 level is associated with Type 2 diabetes mellitus. PMID: 28207876
  3. Coenzyme Q10 reduced HbA1c considerably in overweight and obese patients with diabetes, although interestingly adipolin levels declined simultaneously. In this study, Q10 modulated glucose homeostasis, which was expected to be mediated by increasing adipolin. The similar mechanisms of action of Q10 and adipolin may justify lowering effect of Q10 on adipolin. PMID: 27657997
  4. Serum adipolin concentrations were significantly lower in polycystic ovarian syndrome compared with control subjects. PMID: 24612181
  5. In subcutaneous adipose tissue explants, insulin significantly increased CTRP12 protein expression and secretion. PMID: 24492466
  6. we describe, for the first time, adipolin expression in human chondrocytes as well as the intracellular mechanism involved in its regulation PMID: 22736092
  7. Endopeptidase cleavage generates a functionally distinct isoform of C1q/tumor necrosis factor-related protein-12 (CTRP12) with an altered oligomeric state and signaling specificity. PMID: 22942287
  8. Reports cloning, expression, regulation and function of mouse adipolin (Fam132a) PMID: 21849507

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Subcellular Location
[Adipolin fC1QTNF12]: Secreted.; [Adipolin gC1QTNF12]: Secreted.
Protein Families
Adipolin/erythroferrone family
Tissue Specificity
Predominantly expressed by adipose tissues.
Database Links

HGNC: 32308

OMIM: 616593

KEGG: hsa:388581

STRING: 9606.ENSP00000329137

UniGene: Hs.197613

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