Recombinant Human Protein FAM132A(C1QTNF12)

Code CSB-YP713130HU
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Source Yeast
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Code CSB-EP713130HU
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Source E.coli
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Code CSB-EP713130HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP713130HU
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Source Baculovirus
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Code CSB-MP713130HU
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names C1QTNF12
Uniprot No. Q5T7M4
Alternative Names C1QTNF12; C1QDC2; CTRP12; FAM132AAdipolin; Adipose-derived insulin-sensitizing factor; C1q and TNF related protein 12; Complement C1q tumor necrosis factor-related protein 12) [Cleaved into: Adipolin fC1QTNF12; Adipolin fCTRP12; Adipolin full-length form); Adipolin gC1QTNF12; Adipolin cleaved form; Adipolin gCTRP12)]
Species Homo sapiens (Human)
Expression Region 21-302
Target Protein Sequence GGVGARREAQ RTQQPGQRAD PPNATASASS REGLPEAPKP SQASGPEFSD AHMTWLNFVR RPDDGALRKR CGSRDKKPRD LFGPPGPPGA EVTAETLLHE FQELLKEATE RRFSGLLDPL LPQGAGLRLV GEAFHCRLQG PRRVDKRTLV ELHGFQAPAA QGAFLRGSGL SLASGRFTAP VSGIFQFSAS LHVDHSELQG KARLRARDVV CVLICIESLC QRHTCLEAVS GLESNSRVFT LQVQGLLQLQ AGQYASVFVD NGSGAVLTIQ AGSSFSGLLL GT
Protein Length Full Length of Mature Protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
(From Uniprot)
Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses de novo glucose production in hepatocytes via the PI3K-Akt signaling pathway. Administration lead to reduction of blood glucose. Able to attenuate inflammation in fat tissue.
Gene References into Functions
  1. Adipolin and adiponectin are cytokines that exert substantial impact on obesity, progression of atherosclerosis, insulin resistance, and glucose metabolism. PMID: 29452073
  2. Low serum CTRP12 level is associated with Type 2 diabetes mellitus. PMID: 28207876
  3. Coenzyme Q10 reduced HbA1c considerably in overweight and obese patients with diabetes, although interestingly adipolin levels declined simultaneously. In this study, Q10 modulated glucose homeostasis, which was expected to be mediated by increasing adipolin. The similar mechanisms of action of Q10 and adipolin may justify lowering effect of Q10 on adipolin. PMID: 27657997
  4. Serum adipolin concentrations were significantly lower in polycystic ovarian syndrome compared with control subjects. PMID: 24612181
  5. In subcutaneous adipose tissue explants, insulin significantly increased CTRP12 protein expression and secretion. PMID: 24492466
  6. we describe, for the first time, adipolin expression in human chondrocytes as well as the intracellular mechanism involved in its regulation PMID: 22736092
  7. Endopeptidase cleavage generates a functionally distinct isoform of C1q/tumor necrosis factor-related protein-12 (CTRP12) with an altered oligomeric state and signaling specificity. PMID: 22942287
  8. Reports cloning, expression, regulation and function of mouse adipolin (Fam132a) PMID: 21849507

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Subcellular Location Adipolin fC1QTNF12: Secreted, SUBCELLULAR LOCATION: Adipolin gC1QTNF12: Secreted
Protein Families Adipolin/erythroferrone family
Tissue Specificity Predominantly expressed by adipose tissues.
Database Links

HGNC: 32308

OMIM: 616593

KEGG: hsa:388581

STRING: 9606.ENSP00000329137

UniGene: Hs.197613

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