Recombinant Human Alcohol dehydrogenase 4(ADH4)

Code CSB-EP001356HU
Size US$2466
Image
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

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Product Details

Purity Greater than 90% as determined by SDS-PAGE.
Target Names ADH4
Uniprot No. P08319
Research Area Signal Transduction
Alternative Names Ac1002; ADH 4; ADH-1; ADH-2; ADH2; Adh4; ADH4_HUMAN; Alcohol dehydrogenase 4 (class II) pi polypeptide; Alcohol dehydrogenase 4; Alcohol dehydrogenase class II pi chain; Alcohol dehydrogenase pi isozyme ADH class II; Aldehyde reductase; Class II alcohol dehydrogenase 4 pi subunit
Species Homo sapiens (Human)
Source E.coli
Expression Region 1-380aa
Target Protein Sequence MGTKGKVIKCKAAIAWEAGKPLCIEEVEVAPPKAHEVRIQIIATSLCHTDATVIDSKFEGLAFPVIVGHEAAGIVESIGPGVTNVKPGDKVIPLYAPLCRKCKFCLSPLTNLCGKISNLKSPASDQQLMEDKTSRFTCKGKPVYHFFGTSTFSQYTVVSDINLAKIDDDANLERVCLLGCGFSTGYGAAINNAKVTPGSTCAVFGLGGVGLSAVMGCKAAGASRIIGIDINSEKFVKAKALGATDCLNPRDLHKPIQEVIIELTKGGVDFALDCAGGSETMKAALDCTTAGWGSCTFIGVAAGSKGLTIFPEELIIGRTINGTFFGGWKSVDSIPKLVTDYKNKKFNLDALVTHTLPFDKISEAFDLMNQGKSVRTILIF
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
Mol. Weight 67.2kDa
Protein Length Full Length
Tag Info N-terminal GST-tagged
Form Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA Please contact us to get it.

Target Data

Gene References into Functions
  1. Association between HCRTR2, ADH4,CLOCK gene polymorphisms and cluster headache was not significant in the present study. PMID: 29318394
  2. this current study provides substantial evidence that genetic polymorphisms of rs3805322 in the ADH4 gene may be associated with an increased risk of developing ESCC in two Chinese Han populations. PMID: 26039424
  3. This study confirmed the genetic heterogeneity of cluster headache, suggesting that mutations in the ADH4 gene might be related to cluster headache in a subset of cases. PMID: 24469609
  4. The serum expression of ADH4 protein correlates with the progression of esophageal cancer. PMID: 24051444
  5. expression levels of ADH4 mRNA and protein have found to be markedly reduced in hepatocellular carcinoma (HCC) tissues and significantly associated with survival. PMID: 22147505
  6. data suggest that ADH4 intronic variants play a role in alcohol dependence susceptibility in Italian populations PMID: 22044940
  7. Our results suggest that the analysed polymorphisms ofANKK1 and ADH4 can play an important part in the pathogenesis of alcohol abuse PMID: 22232963
  8. the high catalytic activity of human alcohol dehydrogenase 4 studied with horse liver ADH1E PMID: 21184752
  9. This study confirms the significant relationship of ADH4 variants with AD and related phenotypes. PMID: 20626721
  10. Data indicate that further studies of EPHX1 rs1051740, ADH4 r1042364, and NQO1 rs291766 are needed to make more definitive conclusion on the role of variation in xenobiotic metabolism in ovarian cancer. PMID: 21480392
  11. Our data suggest that cluster headache is associated with the ADH4 gene or a linked locus. Additional studies are warranted to elucidate the role of this gene in the etiopathogenesis of the disease. PMID: 19925625
  12. In this study we have identified a distal upstream enhancer, 4E, of ADH4. In HepG2 human hepatoma cells, 4E increased the activity of an ADH4 basal promoter by 50-fold. 4E was cell-specific. PMID: 20363298
  13. ADH4 gene polymorphisms are associated with upper aerodigestive tract cancers. PMID: 19861527
  14. Thirteen new single nucleotide polymorphisms PMID: 11916005
  15. Identification and characterisation of two allelic forms of human alcohol dehydrogenase 2 PMID: 11964133
  16. kinetic mechanisms for ADH4 functioning as retinol dehydrogenase PMID: 11997393
  17. Results describe the expression patterns of alcohol dehydrogenases I, III, and IV in adult rat, mouse and human tissues using radioactive oligonucleotide in situ hybridization. PMID: 12631290
  18. The mean alcohol-elimination rate among ADH2*2 carriers is significantly higher than among ADH2*1 homozygotes in a male Jewish population. PMID: 14745297
  19. the genotypes of six ADH4 markers were associated with alcohol dependence, and all seven ADH4 markers were associated with drug dependence PMID: 16220108
  20. Seven single nucleotide polymorphisms spanning the ADH4 gene were genotyped in 561 subjects affected with alcohol dependence and/or drug dependence. PMID: 16237392
  21. that personality traits and substance dependence have a partially overlapping genetic basis. PMID: 17069770
  22. Class II alcohol dehydogenase (ADH4) is considered to contribute to ethanol oxidation in the liver at high concentration. PMID: 19182438

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Subcellular Location Cytoplasm
Protein Families Zinc-containing alcohol dehydrogenase family, Class-II subfamily
Database Links

HGNC: 252

OMIM: 103740

KEGG: hsa:127

STRING: 9606.ENSP00000265512

UniGene: Hs.1219

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