ADH4 Antibody

Code CSB-PA001356ESR2HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA001356ESR2HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ADH4 Polyclonal antibody
Uniprot No.
Target Names
ADH4
Alternative Names
Ac1002 antibody; ADH 4 antibody; ADH-1 antibody; ADH-2 antibody; ADH2 antibody; Adh4 antibody; ADH4_HUMAN antibody; Alcohol dehydrogenase 4 (class II) pi polypeptide antibody; Alcohol dehydrogenase 4 antibody; Alcohol dehydrogenase class II pi chain antibody; Alcohol dehydrogenase pi isozyme ADH class II antibody; Aldehyde reductase antibody; Class II alcohol dehydrogenase 4 pi subunit antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Alcohol dehydrogenase 4 protein (1-380AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Catalyzes the NAD-dependent oxidation of either all-trans-retinol or 9-cis-retinol. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Also catalyzes the reduction of benzoquinones.
Gene References into Functions
  1. Association between HCRTR2, ADH4,CLOCK gene polymorphisms and cluster headache was not significant in the present study. PMID: 29318394
  2. this current study provides substantial evidence that genetic polymorphisms of rs3805322 in the ADH4 gene may be associated with an increased risk of developing ESCC in two Chinese Han populations. PMID: 26039424
  3. This study confirmed the genetic heterogeneity of cluster headache, suggesting that mutations in the ADH4 gene might be related to cluster headache in a subset of cases. PMID: 24469609
  4. The serum expression of ADH4 protein correlates with the progression of esophageal cancer. PMID: 24051444
  5. expression levels of ADH4 mRNA and protein have found to be markedly reduced in hepatocellular carcinoma (HCC) tissues and significantly associated with survival. PMID: 22147505
  6. data suggest that ADH4 intronic variants play a role in alcohol dependence susceptibility in Italian populations PMID: 22044940
  7. Our results suggest that the analysed polymorphisms ofANKK1 and ADH4 can play an important part in the pathogenesis of alcohol abuse PMID: 22232963
  8. the high catalytic activity of human alcohol dehydrogenase 4 studied with horse liver ADH1E PMID: 21184752
  9. This study confirms the significant relationship of ADH4 variants with AD and related phenotypes. PMID: 20626721
  10. Data indicate that further studies of EPHX1 rs1051740, ADH4 r1042364, and NQO1 rs291766 are needed to make more definitive conclusion on the role of variation in xenobiotic metabolism in ovarian cancer. PMID: 21480392
  11. Our data suggest that cluster headache is associated with the ADH4 gene or a linked locus. Additional studies are warranted to elucidate the role of this gene in the etiopathogenesis of the disease. PMID: 19925625
  12. In this study we have identified a distal upstream enhancer, 4E, of ADH4. In HepG2 human hepatoma cells, 4E increased the activity of an ADH4 basal promoter by 50-fold. 4E was cell-specific. PMID: 20363298
  13. ADH4 gene polymorphisms are associated with upper aerodigestive tract cancers. PMID: 19861527
  14. Thirteen new single nucleotide polymorphisms PMID: 11916005
  15. Identification and characterisation of two allelic forms of human alcohol dehydrogenase 2 PMID: 11964133
  16. kinetic mechanisms for ADH4 functioning as retinol dehydrogenase PMID: 11997393
  17. Results describe the expression patterns of alcohol dehydrogenases I, III, and IV in adult rat, mouse and human tissues using radioactive oligonucleotide in situ hybridization. PMID: 12631290
  18. The mean alcohol-elimination rate among ADH2*2 carriers is significantly higher than among ADH2*1 homozygotes in a male Jewish population. PMID: 14745297
  19. the genotypes of six ADH4 markers were associated with alcohol dependence, and all seven ADH4 markers were associated with drug dependence PMID: 16220108
  20. Seven single nucleotide polymorphisms spanning the ADH4 gene were genotyped in 561 subjects affected with alcohol dependence and/or drug dependence. PMID: 16237392
  21. that personality traits and substance dependence have a partially overlapping genetic basis. PMID: 17069770
  22. Class II alcohol dehydogenase (ADH4) is considered to contribute to ethanol oxidation in the liver at high concentration. PMID: 19182438

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Subcellular Location
Cytoplasm.
Protein Families
Zinc-containing alcohol dehydrogenase family, Class-II subfamily
Database Links

HGNC: 252

OMIM: 103740

KEGG: hsa:127

STRING: 9606.ENSP00000265512

UniGene: Hs.1219

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