Recombinant Human Autophagy-related protein 9A (ATG9A), partial

1. the nucleation of autophagosomes occurs in endoplasmic reticulum ubulovesicular regions, where the ULK1 complex coalesces with ER and the ATG9 compartment PMID: 27510922
2. the identification of ATG9A as a specific AP-4 cargo PMID: 29180427
3. In the inner ear HEI-OC1 cell line, miR-34a overexpression resulted in an accumulation of phagophores and impaired autophagosome-lysosome fusion, and led to cell death subsequently. Notably, autophagy-related protein 9A (ATG9A), an autophagy protein, was significantly decreased after miR-34a overexpression. Knockdown of ATG9A inhibited autophagy flux, which is similar to the effects of miR-34a overexpression PMID: 28981097
4. Contrary to its normal trafficking between plasma membrane, intracellular organelles and autophagic membranes, ATG9A concentrates in transferrin receptor-positive juxtanuclear recycling endosomes in SMPD1-deficient cells. PMID: 27070082
5. Findings show for this first time that ATG9A loss in trastuzumab resistant cells allowed Her2 to escape from lysosomal targeted degradation through K63 poly-ubiquitination via c-Cbl. PMID: 27050377
6. phosphorylation of mATG9 at Tyr8 by Src and at Ser14 by ULK1 functionally cooperate to promote interactions between mATG9 and the AP1/2 complex. PMID: 27934868
7. In these Rab1B-depleted cells, ATG9A accumulated in intermediate membrane structures at autophagosome formation sites. These results indicate that Rab1B is involved in regulating the proper development of autophagosomes. PMID: 28522593
8. the C-terminal glycine of human ATG9A is required for its transport from the endoplasmic reticulum to the Golgi apparatus PMID: 27663665
9. these findings provide new insights into the intracellular pathways followed by ATG9A to reach different subcellular compartments, and into the intramolecular determinants that drive the sorting of this protein. PMID: 27316455
10. Results suggest that quinocetone stimulates the MRLC-mediated mAtg9 trafficking, which is critical for autophagosome formation, via the ATF6 upregulated expression of DAPK1. PMID: 27085326
11. Importantly, TBC1D14 and TRAPPIII regulate ATG9 trafficking independently of ULK1. PMID: 26711178
12. Data found that the interaction between 14-3-3 zeta and Atg9A is mediated by phosphorylation at Ser761. PMID: 25266655
13. TBC1D5 and the AP2 complex are important novel regulators of the rerouting of ATG9-containing vesicular carriers toward sites of autophagosome formation. PMID: 24603492
14. miR-29b mRNA, MAPK10 protein expression, and ATG9A protein expression are closely related to chemosensitivity of ovarian carcinoma. PMID: 24767251
15. the presence of ATG9A in the cytoplasm of tumor cells may be an independent biomarker for disease recurrence and survival in patients with oral squamous cell carcinoma PMID: 24085552
16. These findings suggest that Bif-1 acts as a critical regulator of Atg9 puncta formation presumably by mediating Golgi fission for autophagosome biogenesis during starvation. PMID: 21068542
17. mAtg9 trafficking through multiple organelles, including recycling endosomes, is essential for the initiation and progression of autophagy PMID: 22456507
18. ATG9A was found by co-immunoprecipitation to interact with FAM48A/p38IP/q8NEM7.2. PMID: 19893488
19. First demonstration that mammalian Atg9A, originally called mAtg9, is required for starvation-induced autophagy, and localizes to Golgi and endosomes. PMID: 16940348
20. In human adult tissues APG9L1 is ubiquitously expressed. PMID: 15755735

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HGNC: 22408

OMIM: 612204

KEGG: hsa:79065

STRING: 9606.ENSP00000355173

UniGene: Hs.323363