Recombinant Human Baculoviral IAP repeat-containing protein 5(BIRC5)

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Code CSB-EP002706HU
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  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

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Product Details

Purity Greater than 90% as determined by SDS-PAGE.
Target Names BIRC5
Uniprot No. O15392
Research Area Cell Biology
Alternative Names API4; Apoptosis inhibitor 4; Apoptosis inhibitor survivin; Apoptosis inhibitor4; Baculoviral IAP repeat containing 5; Baculoviral IAP repeat containing protein 5; Baculoviral IAP repeat-containing protein 5; BIRC 5; BIRC5; BIRC5_HUMAN; EPR 1; IAP4; Survivin variant 3 alpha; SVV; TIAP
Species Homo sapiens (Human)
Source E.coli
Expression Region 1-142aa
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
Mol. Weight 32.5kDa
Protein Length Full Length
Tag Info N-terminal 6xHis-SUMO-tagged
Form Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Basically, we can dispatch the products out in 3-7 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA Please contact us to get it.

Target Data

Function Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis
Gene References into Functions
  1. NF-kappaB activation may infer resistance to apoptosis through the expression of anti-apoptotic genes such as Survivin, which showed progressive increase in expression throughout the oesophageal metaplasia-dysplasia-adenocarcinoma sequence. PMID: 29473241
  2. Study demonstrate that ZIC1 plays a tumor suppressive role in breast cancer, by targeting surviving, significantly downregulating its expression. PMID: 29956756
  3. Studying survivin expression in leukocytes of 144 female rheumatoid arthritis patients this study observed that smoking patients had higher survivin transcription and a remarkable spreading of survivin isoforms. PMID: 27915033
  4. Our findings identify survivin as a target of HO-1 and a mediator of adipocyte-induced survival in the metastatic niche. PMID: 29311669
  5. High BIRC5 expression is associated with gefitinib resistance in lung cancer. PMID: 30106446
  6. miR-203 expression also inhibited primary tumor growth in ovaries and metastatic tumors in multiple peritoneal organs including liver and spleen. miR-203 inhibits ovarian tumor metastasis by targeting BIRC5/survivin and attenuating the TGFbeta pathway. PMID: 30241553
  7. Survivin may be implicated in the bcl-2 and p53 pathways and therefore in the biology of PDAC. Its potential use as a survival predictor and therapeutic target represent a promising field. PMID: 30249893
  8. Study in hepatocellular carcinoma cell line elicited a new mechanism in which IGF-1 induced epithelial-mesenchymal transition through regulation of survivin and a downstream pathway. PMID: 29989646
  9. In the present study, liposomeplasmid DNA encoding mutant survivinT34A could inhibit tumor growth of cervical cancer. This inhibition may be associated with an increase in the apoptosis rate of tumor cells and a reduction in angiogenesis. PMID: 29767242
  10. simvastatin significantly inhibited the proliferation and invasion of SACC83 cells, induced apoptosis, and reduced the expression of survivin, which suggests that simvastatin may be a novel target for salivary gland adenoid cystic carcinoma therapy. PMID: 29956779
  11. Survivin is significantly up-regulated in hepatocellular carcinoma (HCC)tissues and associated with tumor growth and lymph node metastasis. Clinical detection of survivin level combined with MRI examination might be beneficial for clinical diagnosis and treatment of HCC PMID: 30010107
  12. Our study identified the STAT3 rs1053004 C/C as a high-risk genotype in MA with lower survivin and VEGF transcription levels in the peripheral blood. PMID: 30226700
  13. Overexpression of miR-485-5p suppresses breast cancer progression and enhances chemosensitivity. Further study demonstrated that miR-485-5p directly targeted the 3'-untranslated region of survivin and overexpression of survivin overcomes the miR-485-5p induced effects on breast cancer. PMID: 29678577
  14. Survivin expression in gastric cancer cells is regulated by DEC1. PMID: 29204860
  15. High serum survivin levels with GG genotype are associated with Brain Tumors. PMID: 30275230
  16. LNC473 could recruit deubiquitinase USP9X to inhibit the ubiquitination level of survivin and then increase survivin expression. PMID: 29605299
  17. Oct4 plays a vital role in the malignant progression of HCC cells through the survivin/STAT3 signaling pathway. PMID: 29901157
  18. Our study results may suggest that high serum survivin levels can show 4 times increased risk of cancer in a subject with a high suspicion of cancer. Furthermore, survivin level was not influenced with demographic characteristics of breast, gastric, colorectal, prostate, ovarian cancer, and glioblastome multiforme. PMID: 29893319
  19. These findings collectively suggest that the triple combination of survivin knockdown with ABT-263 and trametinib treatment, may be a potential strategy for the treatment of KRAS-mutant lung adenocarcinoma. Furthermore, our findings indicate that the welldifferentiated type of KRAS-mutant lung tumors depends, at least in part, on TTF1 for growth. PMID: 29658609
  20. Targeting the Cripto-1/TAK-1/NF-kappaB/Survivin pathway may be an effective approach to combat apoptosis resistance in cancer. PMID: 29807222
  21. suggests SIRT1 may serve as a predictor of poor prognosis in esophageal squamous cell carcinoma, and its mediated tumor-promoting role might be associated with the overexpression of EGFR protein in esophageal squamous cell carcinoma PMID: 29625788
  22. CSN5 directly bound survivin and decreased its ubiquitination to enhance the protein stability of survivin. PMID: 29596838
  23. The survivin gene 3' UTR polymorphisms (rs17878624) show that GG genotype provides substantial protection from non-small-cell lung carcinoma. PMID: 29631694
  24. Concomitant high expression of survivin and VEGF-C is closely associated with LNM status of PTC patients, which suggests their cooperation in the metastatic process. PMID: 29578160
  25. In leukoplakia, the expression of survivin associated with that of ki-67 reinforces the assumption that all these lesions are potentially malignant. PMID: 28346726
  26. Study showed for the first time that the suppression of rheumatiod arthritis fibroblast-like synoviocyte was mediated by phosphatase and tensin homolog involving survivin silencing. PMID: 28337018
  27. ERCC1 expression may also inhibit esophageal squamous cell carcinoma cell apoptosis via regulating survivin expression, and ERCC1 and survivin overexpression are independent predictors of prognosis for ESCC patients who receive chemotherapy and/or radiotherapy PMID: 30075571
  28. let-7b targets PLK1 to inhibit hepatocellular carcinoma cell growth and induce their apoptosis by attenuating the PLK1-mediated Survivin phosphorylation PMID: 29913237
  29. Overexpression of Survivin in glioma cells induces chromosomal instability PMID: 29282022
  30. High BIRC5 expression is associated with ovarian cancer. PMID: 29795564
  31. In III-rd trimester of pregnancy parameters of Timp-1 and Survivin - anti-apoptotic substances concentration were similar in maternal and cord blood in both artery and vein. We found no increased activity of selected antiapoptotic factors. PMID: 28509321
  32. Results form study in non-small-cell lung cancer cells showed that SphK2 plays a critical role in doxorubicin-induced resistance by regulating key anti-apoptotic gene, survivin. PMID: 28950390
  33. Survivin overexpression plays a key role in the chemoresistance of ovarian CSCs. PMID: 30061219
  34. Survivin may play an important role in the occurrence and development of laryngeal carcinoma, and its high expression is related to the poor prognosis of patients with laryngeal cancer. (Meta-analysis) PMID: 29270761
  35. treatment of DLD1 cells with tamoxifen , betaestradiol, or a combination of these two drugs, inhibited cell viability and migration, promoted cell apoptosis, and reduced the mRNA and protein expression levels of survivin in a dose and timedependent manner. These results provide novel experimental basis for hormonal adjuvant therapy for the treatment of colorectal cancers PMID: 28849238
  36. Studies indicated that high survivin expression in renal cell carcinoma (RCC) was associated with poor overall survival [Review]. PMID: 27411378
  37. Nuclear accumulation of survivin is associated with proliferative phenotype and was shown to be a worse prognostic marker in breast ductal carcinoma. PMID: 29517199
  38. Knockdown of BIRC5, a member of the inhibitor of apoptosis protein family, using either lentiviral vector based CRISPR/Cas9 nickase gene editing or inhibition of survivin using the small-molecule inhibitor YM155, results in the suppression of epithelial to mesenchymal transition in retinal pigment epithelial cells. PMID: 29522718
  39. By downregulation of Sp1 and survivin at the late phase of treatment. PMID: 28713892
  40. The expressions of survivin and STAT2 are up-regulated in skin lesions of PV patients, and their mRNA expressions are positively correlated. PMID: 29089085
  41. Findings suggest that lysosome-associated transmembrane protein 4B (LAPTM4B), vascular endothelial growth factor (VEGF), and nuclear survivin expression are significantly correlated in breast cancer, which may be predictive of prognosis as well as effective therapeutic targets for anticancer therapies. PMID: 28476037
  42. HIF-2alpha dictates the resistance of human pancreatic cancer cells to TRAIL under normoxic and hypoxic conditions and transcriptionally regulates survivin expression. PMID: 28476028
  43. survivin may have a role in recurrence in rectal cancer patients treated with surgery and postoperative concurrent chemo-radiation therapy PMID: 27391438
  44. Results identified BIRC5 to be significantly upregulated in the lung squamous cell carcinoma tissues of smoking patients and may play an important role in diagnosis and prognosis. PMID: 28949095
  45. After cancer cell fusion, some fused cells avoid the apoptotic crisis partly owing to survivin, and continue to proliferate, a process that contributes to human cancer progression. PMID: 28193315
  46. High survivin expression is associated with lung cancer and colorectal cancer. PMID: 27602754
  47. Data suggest that Ki-67 index and survivin may be useful biomarkers for rectal cancer with preoperative chemoradiotherapy. PMID: 29491110
  48. inhibition of apoptosis targeting survivin might represent an effective strategy for both obesity and cancer therapy. PMID: 28518147
  49. FAT10 promotes tumor proliferation by directly stabilizing Survivin protein in breast cancer cells. PMID: 27806337
  50. nuclear survivin is a prognostic marker for the progression of oral squamous cell carcinomas. PMID: 28384094
  51. Survivin expression in tumor tissue and its serum concetration significantly correlate with clinical and histopathological parameters in melanoma patients. PMID: 29328641
  52. Data suggest that KLF4 could promote cell senescence through a complex network: miR-203, survivin, and p21, which were all regulated by overexpression of KLF4 and contributed to cell senescence. PMID: 27531889
  53. The high sensitivity, specificity, and accuracy of serum and aqueous humor survivin and TGF-B1 proteins make them promising markers for early detection and follow-up of RB patients. PMID: 27663628
  54. increased expression of both DNA methytransferase I (DNMT1) and Survivin was observed and significantly correlated with the reduced miR-203 in NSCLC PMID: 27177222
  55. Nuclear survivin expression correlates with endoglin-assessed microvascularisation in laryngeal squamous cell carcinoma. PMID: 28446541
  56. survivin expression modes and YAP localization (Hippo pathway activation modes) were not correlated with survival. In addition, we confirmed that survivin small interference RNA (siRNA) transfection and YM155, an anti-survivin drug, elicited decreased nuclear survivin expression and cell proliferation in ISO-HAS-B cells which expressed survivin consistently PMID: 28845553
  57. Survivin expression in lung squamous cell carcinoma was increased compared to normal tissue, and was unaffected by methylation status of the surviving gene. PMID: 28319412
  58. Survivin gene promoter methylation was more frequent in gastric cancer patients than in controls. PMID: 28319413
  59. These findings uncover the significance of Merlin protein expression and Survivin labeling index as prognosticators for poor clinical outcome in two independent Malignant pleural mesothelioma cohorts. PMID: 27378628
  60. circulating Survivin in prostate cancer patients was higher compared to controls, with the highest levels in African-American (AA) patients. AA patients with prostate cancer contained higher amounts of extracellular vesicles (EVs) in their plasma and sera than European-American (EA) patients. EVs from AA patients with prostate cancer contained higher amounts of Survivin, XIAP and cIAP-2 than EVs from EA patients. PMID: 28981528
  61. results indicate that survivin is of prognostic signi fi cance in patients with renal cell carcinoma PMID: 27489375
  62. The aim of this study was to compare the prognostic value of the histopathological grading and the conventional biomarker MIB-1 with expression of the anti-apoptotic protein survivin to see if this biomarker could complement recurrence prediction. PMID: 28953948
  63. Data suggest that the first 22 bp of exon 3 in BIRC5 contain cis-acting elements that enhance the exclusion of exon 3 to generate the survivin DEx3 mRNA isoform via exclusion/deletion of exon 3; Sam68 is a possible trans-acting factor that binds to this cis-acting element and regulates exon 3 splicing. (BIRC5/survivin = baculoviral IAP repeat containing 5; Sam68 = GAP-associated tyrosine phosphoprotein p62) PMID: 28655776
  64. our data suggest the existence of a novel pre-metastatic phase quiescent-breast cancer stem cells (Q-BCSCs) before epithelial to mesenchymal transition and SURVIVIN acts as a marker for Quiescent-BCSCs PMID: 27411340
  65. Expressions of SDF-1, survivin and smac were significantly higher in epithelial ovarian cancer tissue than those in normal tissue. PMID: 28852723
  66. Effective internalization of SurR9-C84A in Y79 cells induced cytotoxic effects. PMID: 27322712
  67. Survivin expression predicted disease-free survival in high grade papillary urothelial carcinomas. PMID: 27473264
  68. G/G genotype of the survivin -31C/G polymorphism might be a risk factor for UC development. PMID: 28365965
  69. Studies indicate that survivin expression was associated with more aggressive clinical features and predicted poor cancer-specific survival (CSS) and overall survival (OS) in patients with renal cell carcinoma (RCC). PMID: 28178644
  70. This study shows that both survivin and TIIalpha are independent prognostic predictors in human grade II/III astrocytomas stratified for IDH1-mutation status PMID: 28214203
  71. this study shows that c-IAP-2 may prevent HIV-viral protein -mediated mitochondrial depolarization through stabilizing TRAF-1/2 expression and sequential inhibition of caspase-8, Bid, and Bax PMID: 26969755
  72. the N-terminus of survivin is a mitochondrial-targeting sequence that regulates Src. PMID: 27246243
  73. Reciprocal regulation of BMF and BIRC5 is linked to Eomes overexpression in colorectal cancer. PMID: 27539959
  74. A higher survivin expression seems to represent an unfavorable and robust prognostic factor for clinical outcomes in renal cell carcinoma patients [review; meta-analysis]. PMID: 27350406
  75. Aurora-C interactions with members of the Chromosome Passenger Complex (CPC), Survivin and Inner Centromere Protein (INCENP) in reference to known Aurora-B interactions to understand the functional significance of Aurora-C overexpression in human cancer cells, is reported. PMID: 27332895
  76. study revealed a critical role of miR-138- 5p as a tumor suppressive miRNA in bladder carcinogenesis, explored the molecular mechanisms by which aberrant miR-138-5p expression contributes to bladder cancer progression and identified Survivin as a direct target of miR- 138-5p. Regulation of Survivin by miR-138-5p might explain why the decrease of miR-138-5p during bladder carcinogenesis can promote cancer progression. PMID: 27978829
  77. the overexpression of miR-141 augments anoikis resistance in ovarian cancer cells by targeting and repressing the expression of KLF12, which, in turn, competes for binding sites in the survivin promoter with Sp1. The subsequent increase in survivin then protects ovarian cancer cells against anoikis by blocking the intrinsic apoptotic activity. PMID: 28095864
  78. we uncovered that folate deficiency could profoundly downregulate two prominent anti-apoptotic effectors including survivin and glucose-regulated protein-78. Silencing of either survivin or glucose-regulated protein-78 via small interfering RNA interfering technique established that both effectors could serve as reactive oxygen species sinker proteins PMID: 28639913
  79. The results indicate that CXCL12/CXCR4 protects colorectal cancer cells against radiotherapy via survivin, implying an important underlying mechanism of resistance to radiotherapy during colorectal cancer therapy. PMID: 27798120
  80. Survivin was regulated by TGF-beta and was found to be highly expressed during mucosal healing following intestinal inflammation PMID: 27715398
  81. Studies showed that survivin mRNA and protein levels are overexpressed in cervical cancer cells. [meta-analysis] PMID: 27764228
  82. morphine promotes renal cell carcinoma growth and increases RCC progression via over-expression of Survivin PMID: 27866460
  83. Present study indicated that survivin expression is a significant prognostic factor and that survivin is a promising therapeutic target for endometrial cancer. PMID: 27079211
  84. Study suggests that BIRC5 may play a role as a protective factor in the development of intracerebral hemorrhage, and also the brain damage inducing after intracerebral hemorrhage PMID: 27423588
  85. Results showed that both PARP6 and survivin exhibited higher expression in colorectal adenocarcinoma tissues and cell lines. knockdown of either PARP6 or survivin promotes cell apoptosis and inhibits the cell invasion of colorectal adenocarcinoma cells suggesting a significant correlation between theses 2 proteins. PMID: 28260087
  86. the results of the present study demonstrated that injection of the LV carrying survivin into punctured rabbit intervertebral discs acted to delay changes associated with the degeneration of the discs. PMID: 27748828
  87. High expression of survivin is one prognostic factor correlating with low survival rate in glioblastoma. PMID: 27400093
  88. BIRC5 gene has the potential to be a marker for the detection and prognosis of cancer at an early age. PMID: 27372966
  89. results showed that survivin genetic variants were related to EGFR mutation in lung adenocarcinoma patients and might contribute to pathological development to NSCLC. PMID: 27994498
  90. Significantly higher expression of survivin protein in gallbladder cancer as compared to cholelithiasis group suggests its role in gallbladder carcinogenesis though it may not have prognostic value. PMID: 27166029
  91. Survivin protein expression levels were downregulated in both cell lines. PMID: 27430728
  92. Survivin and miRNA-16-1 as potential biomarkers. PMID: 27055667
  93. The aim of the study was to evaluate the caspase-3 and survivin expression in correlation with MIB-1 expression in gliomas of various grade. PMID: 26995334
  94. High survivin expression is associated with ovarian cancer. PMID: 27581819
  95. High survivin expression is Associated with Acne Vulgaris. PMID: 27803511
  96. p53 and Bax might play an important role in microcystin-LR (MC-LR)-induced apoptosis in HepG2 cells in which PUMA and survivin were involved. PMID: 27235693
  97. This study aimed to demonstrate the usefulness of mRNA expression levels of BIRC5 in brush cytology specimens combined with cytology for the diagnosis of malignant biliary stricture PMID: 27399126
  98. IGF-1 signaling activated survivin expression and controlled the expression of EMT biomarkers in the development of GC. PMID: 26271669
  99. Increased survivin expression in choledochal cyst tissue correlated with certain clinical parameters of congenital choledochal cysts. PMID: 27420945
  100. MiR-335 and miR-34a can also regulate GC cell growth, apoptosis, and invasion at least partly through survivin. PMID: 26318298

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Subcellular Location Cytoplasm, Nucleus, Chromosome, Chromosome, centromere, Cytoplasm, cytoskeleton, spindle, Chromosome, centromere, kinetochore, Midbody
Protein Families IAP family
Tissue Specificity Expressed only in fetal kidney and liver, and to lesser extent, lung and brain (PubMed:10626797). Abundantly expressed in adenocarcinoma (lung, pancreas, colon, breast, and prostate) and in high-grade lymphomas (PubMed:14741722, PubMed:16329164). Also exp
Database Links

HGNC: 593

OMIM: 603352

KEGG: hsa:332

UniGene: Hs.744872

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