Recombinant Human Lipid scramblase CLPTM1L (CLPTM1L), partial

Code CSB-YP850323HU1
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Source Yeast
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Code CSB-EP850323HU1
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Source E.coli
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Code CSB-EP850323HU1-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP850323HU1
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Source Baculovirus
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Code CSB-MP850323HU1
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
CLPTM1L
Uniprot No.
Alternative Names
CLPTM1L; CRR9; Cleft lip and palate transmembrane protein 1-like protein; CLPTM1-like protein; Cisplatin resistance-related protein 9; CRR9p
Species
Homo sapiens (Human)
Protein Length
Partial
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Enhances cisplatin-mediated apoptosis, when overexpressed.
Gene References into Functions
  1. using multivariate logistic regression, we observed that haplotype CLPTM1L is significantly associated with poor treatment response PMID: 29450669
  2. research seems to provide strong evidence for an association between CLPTM1L rs402710C/T and TERT rs2736100A/C SNPs and the risk of OSSC, and suggests that higher tumor RTL values and positive hTERT expression may be applicable as early prognostic markers PMID: 28025427
  3. Homozygous carriers of the CLPTM1L minor C allele presented with faster 6 years telomeres shortening rate compared to carriers of the major allele. PMID: 27532233
  4. Variant in CLPTM1L gene is associated with lung cancer susceptibility. PMID: 28335076
  5. CLPTM1L and TERT have been implicated in cancers, and CIITA is considered as the "master control factor" for the expression of NPC-associated MHC class II genes. These suggested that both SNPs might be functional. Altogether, our findings expand our understanding of the genetic contribution to nasopharyngeal carcinoma (NPC), risk and provide novel biological insights into NPC pathogenesis. PMID: 27436580
  6. A case-control study examined the potential association of 4 CLPTM1L SNPs (rs4975616, rs402710, rs401681, and rs31489) with lung cancer in a Chinese Han population. Minor alleles of all four were significantly associated with decreased lung cancer risk. PMID: 26852039
  7. The data demonstrate that CLPTM1L overexpression can predict poor prognosis in patients with lung cancer and suggest that CLPTM1L might be associated with the regulation of cell migration and invasion. PMID: 27062701
  8. Data suggest that single nucleotide polymorphisms (SNPs) in the telomerase (TERT)-cleft lip and palate transmembrane protein 1-like protein (CLPTM1L) locus may play a role in mediating the susceptibility to nasopharyngeal carcinoma (NPC) in Chinese. PMID: 26621837
  9. CLPTM1L Polymorphism is associated with Nasopharyngeal Carcinoma. PMID: 26545403
  10. This meta-analysis suggests that T allele of CLPTM1L-telomerase reverse transcriptase rs401681 polymorphism is associated with an increased PC risk, especially among Chinese. PMID: 25284078
  11. rs2736100 on TERT-CLPTM1L indicates a poor prognosis for lung cancer in the Chinese Han population. PMID: 25966219
  12. Whole exome sequencing followed by immunohistochemistry of fibrolamellar hepatocellular carcinoma cell lines and tumors showed two structural variants resulting in fusion transcripts: DNAJB1-PRKCA and CLPTM1L-GLIS3. PMID: 25122662
  13. miR-494 regulates cell growth, invasion and apoptosis of esophageal squamous cell carcinoma cells by targeting CLPTM1L. PMID: 25480402
  14. This study showed that genetic variation rs31489 in 5p15.33 was directly associated with the reduced risk of lung cancer in Han Chinese. The CLPTM1L gene rs31489-A allele was a protective factor for the development of lung cancer only in nonsmokers. PMID: 25422207
  15. CLPTM1L-rs401681 polymorphism was not associated with lung cancer risk in Chinese males. PMID: 24861918
  16. Six independent risk neoplasm loci marked by common single-nucleotide polymorphisms have been found: five in the TERT gene, and one in CLPTM1L gene, both on chromosome 5. PMID: 25027329
  17. Polymorphisms of CLPTM1L gene is associated with the risk of hepatocellular carcinoma. PMID: 25339005
  18. association of the CLPTM1L polymorphism and the risk of the lung cancer in non-smoking females in China PMID: 25037574
  19. Using TCGA RNASeq data, we found significantly increased expression of both TERT and CLPTM1L in endometrial cancer tissue compared with normal tissue (TERT P = 1.5 x 10(-18), CLPTM1L P = 1.5 x 10(-19)). PMID: 25487306
  20. TERT-CLPTM1L rs401681 CT and CT/TT genotypes are associated with decreased risk of esophageal squamous cell carcinoma. PMID: 25007268
  21. CLPTM1L polymorphisms did not affect the tumor sensitivity to cisplatin combination chemotherapy in our study patients. PMID: 25155038
  22. consumption of alcohol may interact with CLPTM1L polymorphisms to contribute to overall lung cancer susceptibility. PMID: 25526467
  23. Our meta-analysis provides supportive evidence that CRR9p polymorphism may influence a risk of lung cancer and non-small cell lung cancer in a protective model. PMID: 24957041
  24. CLPTM1L SNPs (rs401681 and rs4975616) were not associated with non-small cell lung cancer in a non-smoking Han Chinese population. PMID: 24175795
  25. CLPTM1L polymorphisms rs402710 and rs401681 are risk-conferring factors for the development of lung cancer. [Meta-analysis] PMID: 24907075
  26. our study indicated that the CLPTM1L - rs401681 (G>A) polymorphism was significantly associated with decreased lung cancer risk, especially among European populations. PMID: 24634236
  27. CLPTM1L SNPs are associated with nasopharyngeal carcinoma risk. PMID: 24615621
  28. the role of TERT-CLPTM1L variants in the etiology of esophageal squamous cell carcinoma and lung cancer PMID: 24386361
  29. CLPTM1L rs31489 was a potential biomarker for lung cancer risk in Caucasians PMID: 24535780
  30. the T allele of rs401681 in CLPTM1L-TERT locus predisposes its carriers to pancreatic cancer. PMID: 24577890
  31. Results suggest that CLPTM1L functions as a growth-promoting gene in the pancreas and that overexpression may lead to an abrogation of normal cytokinesis. PMID: 24648346
  32. A protumorigenic role for CLPTM1L that is critical for Ras-driven lung cancers, with potential implications for therapy and chemosensitization. PMID: 24366883
  33. Genetic variants in TERT and CLPTM1L may affect the susceptibility of lung cancer PMID: 23738012
  34. results suggest that genetic variants in the TERT-CLPTM1L gene may predispose individuals to be susceptible to lung cancer, particularly non-small cell lung cancer, in the Chinese population PMID: 23359026
  35. Polymorphism in CLPTM1L gene is associated with lung cancer. PMID: 23908149
  36. The 5p15.33 locus involving CLPTM1L polymorphisms is significantly associated with lung cancer risk. PMID: 23653681
  37. Our results reiterate that genetic variants of TERT and CLPTM1L contribute to lung cancer susceptibility in Chinese population. PMID: 23433592
  38. TERT-CLPTM1L genomic region was associated with increased risk of cancer. PMID: 23707794
  39. Longer telomere length in peripheral white blood cells is associated with risk of lung cancer and the rs2736100 (CLPTM1L-TERT) polymorphism. PMID: 23555636
  40. The 5p15.33 region containing telomerase reverse transcriptase gene (TERT) and cleft lip and palate transmembrane protein 1-like (CLPTM1L) gene showed significant association with lung cancer in Han Chinese. PMID: 23368278
  41. CLPTM1L is a mitochondria protein that may be associated with an anti-apoptotic mechanism which affects drug-resistance in lung cancer cells. PMID: 23300716
  42. TERT-CLPTM1L rs401681[C] allele is risk factor for basal cell carcinoma but not for squamous cell carcinoma. PMID: 22893025
  43. association between genetic polymorphism and cancer risk PMID: 23226346
  44. Further molecular characterization by flow-FISH and quantitative RT-PCR suggest TERT and CLPTM1L as target genes of 5p15.33 rearrangements. PMID: 23137523
  45. The CT genotype at rs401681 was more common and the TT genotype was rare in patients, and the differences were significant between lung adenocarcinoma patients and controls. This was also true for rs402710. Moreover, the frequency of the GGCTCT haplotype was higher and the TTTTTT frequency was lower in patients, especially those with lung adenocarcinoma. PMID: 22370939
  46. haplotype G-T-A in CLPTM1L also confers a risk to glioma suggesting CLPTM1L is also involved in the etiology of glioma. PMID: 22213090
  47. This study implicates anti-apoptotic CLPTM1L function as a potential mechanism of susceptibility to lung tumorigenesis and resistance to chemotherapy. PMID: 22675468
  48. We genotyped eleven SNPs in 2,892 women of African descent but were unable to detect any significant association between TERT-CLPTM1L SNPs and their predispositions for breast cancer risk. PMID: 22134622
  49. the TERT-CLPTM1L locus influences melanoma risk. PMID: 21993562
  50. the lung cancer susceptibility locus Tert-Clptm1l on chromosome 5p15.33 increases the risk for bronchial obstruction and emphysema. PMID: 21622582

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Subcellular Location
Membrane; Multi-pass membrane protein.
Protein Families
CLPTM1 family
Database Links

HGNC: 24308

OMIM: 612585

KEGG: hsa:81037

STRING: 9606.ENSP00000313854

UniGene: Hs.444673

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