Recombinant Human Cullin-4A (CUL4A)

1. The replication initiation determinant protein PHIP modulates replication by recruiting CUL4 to chromatin. PMID: 30018425
2. Downregulation of CUL4A expression inhibited cell proliferation, migration and invasion, and increased the percentage of cell apoptosis, in HEPG2 and MHCC97H cells, while CUL4A overexpression led to the opposite effects. PMID: 30015884
3. Results suggested that miR377 is a significant negative regulator of CUL4A that controls cancer cell progression in ovarian cancer cell lines. PMID: 29512715
4. These results suggest that different DDB1-CUL4 associated factors play distinct roles in human lung adenocarcinoma development. PMID: 28336923
5. The identification of CUL4A as a downstream target of TGF-beta1 represents a critical pro-survival mechanism in breast cancer progression and provides another point for therapeutic intervention in breast cancer. PMID: 28902348
6. Our data demonstrate that overexpression of CUL4A plays an oncogenic role in iCCA and adversely affects disease-free survival. Thus, it may prove to be a powerful prognostic factor and a potential therapeutic target. PMID: 28576144
7. JMJD2C regulated the activities of lung cancer cells by directly controlling the expression of CUL4A in JMJD2C over-expression cell line. PMID: 28236704
8. plays a critical role in perihilar cholangiocarcinoma (PHCC) metastasis by facilitating PHCC cell motility and cell invasion as well as consequent induction of epithelial to mesenchymal transition via, at least partially, up-regulating transcriptional regulation factor ZEB1 PMID: 28428711
9. The CUL4A interacts with WD-40 proteins through the adaptor protein DNA damage-binding protein 1 (DDB1) to target substrates for ubiquitylation. PMID: 28886238
10. knockdown of cullin 4A via small interfering RNA inhibited the proliferation of the multiple myeloma cell lines by delaying cell-cycle progression and increasing apoptosis. cullin 4A downregulation inhibited multiple myeloma cell migration and invasion in vitro. Our results suggested that cullin 4A could be a promising therapy target in multiple myeloma patients PMID: 28677427
11. decreased tumour growth and increased chemosensitivity to gemcitabine were also noted after Cul4A knockdown. PMID: 26969027
12. CUL4A played an oncogene role through ZEB1 in IL-6-induced colorectal carcinoma progression. PMID: 27418574
13. Overexpression of miR-494 inhibited proliferation, migration, invasion and EMT of ovarian cancer cells by directly suppressing CUL4A expression. Therefore, our findings indicate that miR-494/CUL4A axis is important in the control of ovarian cancer tumorigenesis. PMID: 27983981
14. CUL4A sensitizes colorectal cancer cells to cisplatin induced cell death. PMID: 28095394
15. Elevated expression of CUL4A is positively correlated with distant metastases. PMID: 26055549
16. Increased CUL4A expression is associated with osteosarcoma. PMID: 26715273
17. Findings indicate the importance of a microRNAs miR-9/137-CUL4A-Hippo signaling axis in gastric cancer (GC), and suggest new therapeutic targets for future treatment of GC. PMID: 26840256
18. CUL4A facilitates hepatocarcinogenesis by promoting cell cycle progression and epithelial-mesenchymal transition. PMID: 26593394
19. this study proposes that inflammation-induced Jak-STAT3 signaling leads to colon cancer development through proteasomal degradation of DICER1 by ubiquitin ligase complex of CUL4A(DCAF1), which suggests a novel therapeutic opportunity for colon cancer PMID: 26965998
20. We observed that knockdown of Cul4A was associated with increased sensitivity to gemcitabine through upregulation of TGFBI in lung cancer cells. PMID: 26503734
21. Amplification of CUL4A, IRS2, and TFDP1 genes showed a significant difference in disease-free survival by both univariate and multivariate survival analyses in intrahepatic cholangiocarcinoma. PMID: 26684807
22. These results suggest a linkage between Cul4A and Gli1 expression in human mesothelioma. PMID: 26218750
23. PR-Set7 is a direct target of Cul4A for degradation and involved in the formation of lung tumors in the conditional Cul4A transgenic mouse model. PMID: 26104890
24. CUL4A regulated EGFR transcriptional expression. PMID: 25413624
25. eEF1A1 may mediate SAMHD1 turnover by targeting it to the proteosome for degradation through association with Cullin4A and Rbx1. PMID: 25423367
26. Our results suggest a synergistic effect between CUL4A high levels and the activation of the RAS pathway in the tumorigenesis of basal-like breast cancer tumors PMID: 24870930
27. we observed an increased level of polyubiquitination on p53 in CUL4B overexpressing stable cell line upon treatment with siRNA specific for CUL4A indicating that CUL4B plays a vital role in p53 stability. PMID: 24452595
28. dysfunctional Pex7p, including mutants from RCDP patients, is degraded by a ubiquitin-dependent proteasomal pathway involving the CRL4A (Cullin4A-RING ubiquitin ligase) complex. PMID: 24989250
29. The results of this study indicated that CUL4A enhances pituitary cell proliferation, migration and invasion and may thus contribute to pituitary tumor development and progression. PMID: 24420924
30. CUL4A ubiquitin ligase plays a key role in a wide range of cellular processes, including the cell cycle, chromatin remodelling, DNA damage response, DNA replication, spermatogenesis and haematopoiesis. PMID: 24522884
31. CUL4A and ERK1/2 participated in multi-drug resistance in breast cancer through regulation of MDR1/P-gp expression. PMID: 24368600
32. Findings indicate that Cul4A is oncogenic in vivo and that Cul4A over-expression is associated with cisplatin resistance in lung cancer cells. PMID: 24648314
33. CUL4A has a pivotal role in regulating the metastatic behavior of breast cancer cells in a process involving ZEB1 PMID: 24305877
34. These results indicate that both yeast Rtt101Mms1 and human Cul4ADDB1 are required for efficient deposition of new H3 onto DNA. PMID: 24209620
35. DLC1 was ubiquitinated and degraded by cullin 4A-RING ubiquitin ligase (CRL4A) complex interaction with DDB1 and the FBXW5 substrate receptor. PMID: 24082123
36. p73 interacts with the CDL4A complex by binding directly to DDB1. The CDL4A complex is able to monoubiquitylate p73, negatively affecting its transcriptional function. PMID: 23085759
37. The EZH2-DCAF1/DDB1/CUL4 represents a previously unrecognized methylation-dependent ubiquitination machinery specifically recognizing "methyl degron"; nonhistone protein stability can be dynamically regulated in a methylation-dependent manner. PMID: 23063525
38. potential GRK5 interacting proteins and the association of GRK5 with DDB1 in cell and the regulation of GRK5 level by DDB1-CUL4 ubiquitin ligase complex-dependent proteolysis pathway PMID: 22952844
39. subjects with tumors that highly expressed CUL4A had poor overall survival and CUL4A downregulation inhibited cell proliferation and induced apoptosis in vitro and in vivo. PMID: 22422151
40. Findings indicate structural and conformational insights of the DDB1-CUL4A(DDB2) E3 ligase, with significant implications for the regulation and overall organization of the proteins responsible for initiation of nucleotide-excision repair (NER) pathway. PMID: 22822215
41. Activation of EGFR inhibits the interaction of PCNA with CUL4A, whereas inhibition of EGFR leads to increased CUL4A-PCNA interaction and CUL4A-dependent ubiquitin-mediated degradation of PCNA PMID: 22692198
42. Artemis and DDB2 regulate p27 via the Cul4A-based E3 ligase complex. PMID: 22134138
43. study indicates that Cul4A amplification and overexpression play an oncogenic role in the pathogenesis of mesothelioma PMID: 19929949
44. hCUL4A suppresses apoptosis and DNA damage by regulating apoptosis-related proteins and cell cycle regulators (Bcl-2, caspase-3, p53 and p27); consequently, hCUL4A promotes cell survival. PMID: 22120631
45. Studies indicate the modular architecture of DDB1-CUL4 in complex with DDB2, CSA and CDT2 in DNA repair of UV-induced DNA lesions. PMID: 21550341
46. the CUL4A.DDB1 E3 complex is important for regulation of RASSF1A during mitosis, and it may contribute to inactivation of RASSF1A and promoting cell cycle progression PMID: 21205828
47. 13q34 amplification may be of relevance in tumor progression of breast cancers by inducing overexpression of CUL4A and TFDP1, important in cell cycle regulation. These genes were also overexpressed in non-basal-like tumor samples. PMID: 19995430
48. DDB1 modulates the function of APC/C(Cdh1) in a manner independent of the Cul4-DDB1 complex PMID: 20395298
49. TFDP1, CUL4A, and CDC16 are probable targets of an amplification mechanism and therefore may be involved, together or separately, in development and/or progression of some hepatocellular carcinomas PMID: 12029633
50. DET1 promotes ubiquitination and degradation of c-Jun by assembling a multisubunit ubiquitin ligase containing DNA Damage Binding Protein-1 (DDB1), cullin 4A (CUL4A), Regulator of Cullins-1 (ROC1), and constitutively photomorphogenic-1 PMID: 14739464

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HGNC: 2554

OMIM: 603137

KEGG: hsa:8451

STRING: 9606.ENSP00000364589

UniGene: Hs.339735