Recombinant Human DCC-interacting protein 13-alpha (APPL1)

1. Present study demonstrated that expression of APPL1 protein and mRNA was upregulated in gastric carcinoma (GC) tissues and cell lines. The expression of APPL1 in GC was statistically associated with metastasis stage. Overexpression of APPL1 promotes invasion and metastasis of gastric cancer cells and the underlying molecular mechanism may facilitate EMT via Akt2 phosphorylation. PMID: 28902365
2. APPL1 positively mediated leptin signaling. PMID: 27820851
3. Decreased expression of APPL1 is associated with polycystic ovary syndrome. PMID: 27075719
4. Results indicate that persistent rab5 overactivation through beta-cleaved carboxy-terminal fragment of APP-APPL1 interactions constitutes a novel APP-dependent pathogenic pathway in Alzheimer's disease PMID: 26194181
5. Data show that signal transducing adaptor proteins APPL1 and APPL2 are required for TGFbeta-induced nuclear translocation of TGFbeta type I receptor (TbetaRI)-ICD and for cancer cell invasiveness of prostate and breast cancer cell lines. PMID: 26583432
6. Low expression of APPL1 is associated with metastasis in prostate cancer. PMID: 26473288
7. APPL1 endosomes represent a distinct population of Rab5-positive sorting endosomes. PMID: 26459602
8. article provides evidence that GG genotype and G carrier (CG+GG) genotypes of the rs4640525 polymorphism in the APPL1 gene may be suitable susceptibility biomarkers for NAFLD PMID: 26731990
9. Two loss-of-function mutations in APPL1, identified by means of whole-exome sequencing, found in two large families with a high prevalence of Familial Diabetes Mellitus. PMID: 26073777
10. A role for APPL1 in TLR3/4-dependent TBK1 and IKKepsilon activation in macrophages. PMID: 25780039
11. ATM is the central modulator of APPL-mediated effects on radiosensitivity and DNA repair. PMID: 24763056
12. APPL1 sensitizes insulin signaling by acting at a site downstream of the IR. Study uncovers a mechanism regulating insulin signaling and crosstalk between the insulin and adiponectin pathways. PMID: 24813896
13. APPL1 is a positive regulator of Dvl2-dependent transcriptional activity of AP-1. PMID: 25622892
14. It concludes that APPL1(PH) binding to BAR domain and Reptin is mutually exclusive which regulates the nucleocytoplasmic shuttling of Reptin. PMID: 23891720
15. The activated EGF receptor enters distinct sub-populations of SNX15- and APPL1-labelled peripheral endocytic vesicles. PMID: 23986476
16. C-APPL1/A-APPL2 allele combination is associated with non-alcoholic fatty liver disease occurrence, with a more severe hepatic steatosis grade and with a reduced adiponectin cytoprotective effect on liver. PMID: 23977033
17. TRAF6-mediated ubiquitination of APPL1 is a vital step for the hepatic actions of insulin through modulation of membrane trafficking and activity of Akt. PMID: 23909487
18. Rab5a and APPL1 are overexpressed in breast cancer, and are positively correlated with the HER-2 expression. PMID: 23291133
19. neurons with APPL1-positive granules were restricted to the CA1 area and subiculum, areas associated with hippocampal vulnerability, suggesting a possible link between the perisomatic accumulation of APPL1 and Alzheimer's disease. PMID: 23246927
20. APPL1 regulates basal NF-kappaB activity by modulating the stability of NIK, which affects the activation of p65. PMID: 22685329
21. analysis of APPL1 and APPL2 proteins and their interaction with Rab PMID: 23055524
22. APPL1 is a novel target in endoplasmic reticulum (ER) stress-induced insulin resistance and PKCalpha is the kinase mediating ER stress-induced phosphorylation of APPL1 at Ser(430). PMID: 22685300
23. results demonstrate an important new function for APPL1 in regulating cell migration and adhesion turnover through a mechanism that depends on Src and Akt PMID: 22379109
24. Genetic variation(s) in APPL1/2 may be associated with CAD risk in T2DM in Chinese population. PMID: 22340213
25. Treating C2C12 myotubes with adiponectin promoted APPL1 interaction with protein phosphatase 2A (PP2A) and protein kinase Czeta (PKCzeta), leading to the activation of PP2A and subsequent dephosphorylation and inactivation of PKCzeta. PMID: 21835890
26. These findings suggest that APPL1 is required for EGFR signaling by regulation of EGFR stabilities through inhibition of Rab5. PMID: 22037462
27. Data suggest that although annexin A2 is not an exclusive marker of APPL1/2 endosomes, it has an important function in membrane recruitment of APPL proteins, acting in parallel to Rab5. PMID: 21645192
28. APPL1 plays a key role in coordinating the vasodilator and vasoconstrictor effects of insulin by modulating Akt-dependent NO production and ERK1/2-mediated ET-1 secretion in the endothelium. PMID: 21926268
29. APPL1 abundance is significantly higher in type 2 diabetic muscle; Improvements in hyperglycaemia and hypoadiponectinaemia are associated with reduced skeletal muscle APPL1, and increased plasma adiponectin levels and muscle AMPK phosphorylation. PMID: 21562756
30. Results show that APPL1 is recruited to aggresomes induced by proteasomal stress, and suggest that proteasome inhibitors in clinical use affect the localization, ubiquitination and solubility of APPL1. PMID: 21320486
31. The adapter protein APPL1 links FSH receptor to inositol 1,4,5-trisphosphate production and is implicated in intracellular Ca(2+) mobilization. PMID: 21285318
32. Data indicate APPL1 functions as a scaffolding protein to facilitate adiponectin-stimulated p38 MAPK activation in myotubes. PMID: 20978232
33. [REVIEW] Emerging roles for AppL1. APPL1 has been shown to interact with a variety of membrane receptors. Recent subcellular localizations of APPL1 place it in dynamic and varied venues in the cell: the cell membrane, the nucleus and the early endosomes PMID: 20600589
34. Studies indicate that APPL1 has been recently identified as an AdipoR1 and AdipoR2 binding protein. PMID: 20875820
35. significant fluorescence resonance energy transfer between APPL minimal BAR domain FRET pairs PMID: 20814572
36. The promyogenic function of Cdo involves a coordinated activation of p38MAPK and Akt via association with scaffold proteins, JLP and Bnip-2 for p38MAPK and APPL1 for Akt. PMID: 20484574
37. Rab5a promoted proliferation of ovarian cancer cells, which may be associated with the APPL1-related epidermal growth factor signaling pathway. PMID: 20412119
38. Used mass spectrometry (MS) to identify 13 phosphorylated residues within APPL1. PMID: 20095645
39. identification of a pathway directly linking the small GTPase Rab5, a key regulator of endocytosis, to signal transduction and mitogenesis via APPL1 and APPL2, two Rab5 effectors PMID: 15016378
40. APPL1 is a potential interactor with FSHR PMID: 15070827
41. APPL1 interacts with adiponectin receptors in mammalian cells and the interaction is stimulated by adiponectin. PMID: 16622416
42. APPL1 acts as a common downstream effector of Adiponectin receptors R1 and -R2, mediating adiponectin-evoked endothelial nitric oxide production and endothelium-dependent vasodilation. PMID: 17287464
43. The ability of APPL1 to interact with multiple signaling molecules and phospholipids supports an important role for this adaptor in cell signaling. PMID: 17502098
44. The crystal structures of human APPL1 N-terminal BAR-PH domain motif, is reported. PMID: 17581628
45. These data suggest that APPL1 plays an important role in insulin-stimulated Glut4 translocation in muscle and adipose tissues and that its N-terminal portion may be critical for APPL1 function. PMID: 17848569
46. The findings suggest a role for APPL1 and APPL2 protein as dynamic scaffolds that modulate RAB5-associated signaling endosomal membranes by their ability to undergo domain-mediated oligomerization, membrane targeting and phosphoinositide binding. PMID: 18034774
47. Thus, binding to APPL1 helps localize OCRL at specific cellular sites, and disruption of this interaction may play a role in disease. PMID: 18307981
48. Adiponectin blocks interleukin-18-mediated endothelial cell death via APPL1-dependent AMP-activated protein kinase (AMPK) activation and IKK/NF-kappaB/PTEN suppression. PMID: 18632660
49. APPL proteins exert their stimulatory effects on beta-catenin/TCF-dependent transcription by decreasing the activity of a Reptin-containing repressive complex PMID: 19433865
50. Adiponectin activates AMP-activated protein kinase in muscle cells via APPL1/LKB1-dependent and phospholipase C/Ca2+/Ca2+/calmodulin-dependent protein kinase kinase-dependent pathways PMID: 19520843

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HGNC: 24035

OMIM: 604299

KEGG: hsa:26060

STRING: 9606.ENSP00000288266

UniGene: Hs.476415