Recombinant Human Dipeptidyl peptidase 8 (DPP8), partial

Code CSB-YP744278HU
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Source Yeast
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Code CSB-EP744278HU
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Source E.coli
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Code CSB-EP744278HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP744278HU
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Source Baculovirus
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Code CSB-MP744278HU
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Source Mammalian cell
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Product Details

>85% (SDS-PAGE)
Target Names
Uniprot No.
Alternative Names
Dipeptidyl peptidase 8; Dipeptidyl peptidase IV-related protein 1; Dipeptidyl peptidase VIII; Dipeptidylpeptidase 8; DP8; DPP VIII; Dpp8; DPP8_HUMAN; DPRP-1; DPRP1; EC; MSTP141; Prolyl dipeptidase DPP8
Homo sapiens (Human)
Protein Length
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Please contact us to get it.

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Target Background

Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2 (Probable). Acts as an inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis: inhibits pyroptosis by preventing activation of NLRP1 and CARD8 via an unknown mechanism.
Gene References into Functions
  1. The DPP8 expressing cell model system is a very useful and promising system for investigating the selectivity and associated toxicity of DPP4 inhibitors on DPP8. PMID: 25464020
  2. The SUMO1-E67 interacting loop peptide is an allosteric inhibitor of the dipeptidyl peptidases 8 and 9. PMID: 24072711
  3. Suggest roles for DPP8 and DPP9 in lymphocyte activation and apoptosis and in hepatocytes during liver disease pathogenesis. PMID: 23704821
  4. DPP8 was found in macrophages of carotid atherosclerotic plaque and may play a role in disease progression. PMID: 23608773
  5. analysis of dipeptidyl peptidases 8 and 9 reveals that they may have compensatory roles PMID: 23519473
  6. this study demonstrates for the first time that DP8 and DP9 are expressed in breast and ovarian carcinoma cell lines PMID: 22736146
  7. Data identify modification points in the topology of a representative DPP8/9-inhibitor, capable of rendering selectivity for DPP8 over DPP9. PMID: 21711053
  8. This is the first study to demonstrate the presence of DP8 in chronic lymphocytic leukemia (CLL) and the upregulation of DP8 mRNA in CLL. PMID: 20534982
  9. DPP8 and DPP9 prevail over canonical DPP-IV/CD26 and FAPalpha in all examined meningioma patients PMID: 20043068
  10. cells overexpressing DP8 exhibit behavioral changesin the presence of ECM components; these effects were independent of enzyme activity PMID: 16700509
  11. Dipeptidyl peptidase 8 and dipeptidyl peptidase 9 influence cell-extracellular matrix interactions, and thus may regulate tissue remodeling. PMID: 16704418
  12. study has identified the residues absolutely required for the optimal activity of DPP8 and its unique substrate specificity PMID: 17040910
  13. DP8 cleavage of the N-terminal two residues of IP10 (CXCL10), ITAC (CXCL11) and SDF-1 (CXCL12), is reported. PMID: 18275857
  14. DP8 and DP9 tissue and cellular expression PMID: 19581630

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Subcellular Location
Protein Families
Peptidase S9B family, DPPIV subfamily
Tissue Specificity
Ubiquitously expressed, with highest levels in testis, placenta, prostate, muscle and brain.
Database Links

HGNC: 16490

OMIM: 606819

KEGG: hsa:54878

STRING: 9606.ENSP00000339208

UniGene: Hs.458609

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