DPP8 Antibody

1. The DPP8 expressing cell model system is a very useful and promising system for investigating the selectivity and associated toxicity of DPP4 inhibitors on DPP8. PMID: 25464020
2. The SUMO1-E67 interacting loop peptide is an allosteric inhibitor of the dipeptidyl peptidases 8 and 9. PMID: 24072711
3. Suggest roles for DPP8 and DPP9 in lymphocyte activation and apoptosis and in hepatocytes during liver disease pathogenesis. PMID: 23704821
4. DPP8 was found in macrophages of carotid atherosclerotic plaque and may play a role in disease progression. PMID: 23608773
5. analysis of dipeptidyl peptidases 8 and 9 reveals that they may have compensatory roles PMID: 23519473
6. this study demonstrates for the first time that DP8 and DP9 are expressed in breast and ovarian carcinoma cell lines PMID: 22736146
7. Data identify modification points in the topology of a representative DPP8/9-inhibitor, capable of rendering selectivity for DPP8 over DPP9. PMID: 21711053
8. This is the first study to demonstrate the presence of DP8 in chronic lymphocytic leukemia (CLL) and the upregulation of DP8 mRNA in CLL. PMID: 20534982
9. DPP8 and DPP9 prevail over canonical DPP-IV/CD26 and FAPalpha in all examined meningioma patients PMID: 20043068
10. cells overexpressing DP8 exhibit behavioral changesin the presence of ECM components; these effects were independent of enzyme activity PMID: 16700509
11. Dipeptidyl peptidase 8 and dipeptidyl peptidase 9 influence cell-extracellular matrix interactions, and thus may regulate tissue remodeling. PMID: 16704418
12. study has identified the residues absolutely required for the optimal activity of DPP8 and its unique substrate specificity PMID: 17040910
13. DP8 cleavage of the N-terminal two residues of IP10 (CXCL10), ITAC (CXCL11) and SDF-1 (CXCL12), is reported. PMID: 18275857
14. DP8 and DP9 tissue and cellular expression PMID: 19581630

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HGNC: 16490

OMIM: 606819

KEGG: hsa:54878

STRING: 9606.ENSP00000339208

UniGene: Hs.458609