Recombinant Human Disintegrin and metalloproteinase domain-containing protein 8 (ADAM8), partial, Biotinylated

1. Authors conclude that ADAM8 promotes early metastatic processes such as transendothelial migration by upregulation of MMP-9 and shedding of PSGL-1 from breast cancer cells. PMID: 28986926
2. ADAM8 on leukocytes holds a proinflammatory function in acute lung inflammation by promoting alveolar leukocyte recruitment. PMID: 28596294
3. miR-720 is elevated in serum of patients with ADAM8-high TNBC and, in a group with other miRNAs downstream of ADAM8, holds promise as a biomarker for early detection of or treatment response of ADAM8-positive triple-negative breast cancer PMID: 27039296
4. ADAM8 causes temozolomide resistance in glioblastoma cells by enhancing pAkt/PI3K, pERK1/2, and cleavage of CD44 and HGF R/c-met PMID: 25825051
5. ADAM8 promotes GC cell proliferation and invasion, and its expression is positively correlated with poor survival, indicating that it might be a promising target in GC therapy PMID: 26024798
6. ADAM8 expression is associated with increased migration and invasiveness of pancreatic ductal adenocarcinoma cells. PMID: 25629724
7. ADAM8 and endostatin play a role in osteosarcoma progression. PMID: 25481287
8. Data indicate that fibronectin fragments (FN-fs) are present in adult ntervertebral disc (IVD) from adult subjects, and ADAM-8, known to cleave FN, is present at the pericellular matrix of disc cells. PMID: 25010013
9. Results show that ADAM8 is overexpressed in colorectal cancer and promotes cell growth. PMID: 25098630
10. N-glycosylation is essential for processing, localization, stability, and activity of ADAM8. PMID: 25336660
11. ADAM8 expression is increased in both severe asthma and COPD and associated with sputum total cell count and neutrophils. ADAM8 may facilitate neutrophil migration to the airways in severe asthma and COPD. PMID: 24147597
12. ADAM8 is abundantly expressed in breast tumors and derived metastases compared to normal tissue. PMID: 24375628
13. High ADAM8 expression is associated with pancreatic adenocarcinoma. PMID: 24526468
14. Data show that Cu2+-generated reactive oxygen species (ROS), human ADAM8, ADAM10, and ADAM17 are all capable of cleaving mouse PrP (MoPrP). PMID: 24247244
15. ADAM8 was highly expressed in 54.3% of hepatocellular carcinoma patients. ADAM8 expression was closely associated with tumor size, histological differentiation, recurrence, metastasis, and stage. High levels of ADAM8 resulted in poor prognosis. PMID: 22878099
16. We used immunohistochemistry to compare ADAM8 protein expression in HCC and normal liver tissues and further analyze the ADAM8 protein expression in 105 HCC cases. Studied knocked down expression of ADAM8 in HepG2 cells. PMID: 22965687
17. ADAM8 was robustly expressed by airway granulocytes in lung sections from human asthma patients PMID: 23670189
18. These findings suggest for the first time that ADAM8 is frequently overexpressed in human gliomas and is closely associated with poor clinical outcome. PMID: 21983884
19. ADAM8 mRNA & protein were highly expressed in medulloblastoma tissues when compared with normal cerebellum. This correlated with advanced stage, aggressive type, undifferentiated tumor & decreased survival. PMID: 22959284
20. High expression of ADAM8 is associated with hepatocellular carcinoma. PMID: 22941466
21. Upregulation of a disintegrin and metalloprotease 8 influences tumor metastasis with osteosarcoma. PMID: 22215309
22. variation in the ADAM8 gene may affect serum sADAM8 concentrations and the risk of myocardial infarction PMID: 21640993
23. ADAM8 is both associated with PSGL-1 through the ezrin-radixin-moesin actin-binding proteins and able to cause the proteolytic cleavage of this adhesion receptor. PMID: 22229154
24. gene expressions for ADAM8 and ADAM15 were notably lower in ascending aorta as compared with aortic dissection PMID: 21728902
25. increased expression in allergic rhinitis PMID: 21679521
26. It regulates onset of blood circulation. (review) PMID: 21077325
27. ADAM8 is a promising candidate to be involved in atherosclerosis, and its 2662 T/G allelic variant significantly associates with advanced atherosclerotic lesion areas and myocardial infarction. PMID: 19575316
28. ADAM8 and EGFR are overexpressed in non-small cell lung cancer. PMID: 18710625
29. expression of truncated forms of ADAM8 by the lung cancer cells may result in the specific upregulation of their invasive and osteoclastogenic activities in the bone microenvironment PMID: 20453887
30. Overexpression of ADAM8 is associated with lung cancer progression PMID: 15623614
31. ADAM8 may contribute to the airway remodeling process that occurs with asthma progression. PMID: 17339047
32. All these data support a potential relevant role for ADAM-8 in the function of neutrophils during inflammatory response. PMID: 17548643
33. ADAM8 is overexpressed in pancreatic ductal adenocarcinoma, influences cancer cell invasiveness and correlates with reduced survival. PMID: 17979891
34. ADAM8 may have a role as a hypoxia-dependent protein in the pathogenesis and evolution of pancreatic cancer PMID: 18566576
35. ADAM8 might be a therapeutic target for allergic respiratory diseases. PMID: 18691140
36. Autoactivation of ADAM8: a novel pre-processing step is required for catalytic activity. PMID: 18811590
37. ADAM8 is up-regulated upon formation of multinuclear giant cells after HPIV2 induction. PMID: 19284887
38. The structure, function & expression of ADAM8 and its role in asthma are reviewed. Review. PMID: 19397475
39. Increasing trend for ADAM8 expression is associated with early to advanced stages of myelodysplastic syndrome. PMID: 19469654
40. ADAM-8 as a fibronectinase in human osteoarthritis chondrocytes. PMID: 19714641
41. the effects of pH on substrate cleavage by ADAM8 beyond autocatalysis PMID: 19766586

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HGNC: 215

OMIM: 602267

KEGG: hsa:101

STRING: 9606.ENSP00000453302

UniGene: Hs.501574