Recombinant Human Golgin subfamily A member 2 (GOLGA2), partial

1. In situ proximity ligation assays of Golgi localization of alpha-mannosidase IA at giantin versus GM130-GRASP65 site, and absence or presence of N-glycans terminated with alpha3-mannose on trans-Golgi glycosyltransferases may be useful for distinguishing indolent from aggressive prostate cancer cells. PMID: 28782625
2. GM130 upregulated expression of the key epithelial-mesenchymal transformation regulator Snail (SNAI1), which mediated EMT activation and cell invasion by GM130. PMID: 26617790
3. the study identified GM130 as a novel target of Coxsackievirus B3 (CVB3), which may implicate in the pathogenesis of CVB3-induced acute pancreatitis. PMID: 26314804
4. We describe the first human patient with a homozygous apparently loss of function mutation in GOLGA2. The phenotype is a neuromuscular disorder characterized by developmental delay, seizures, progressive microcephaly, and muscular dystrophy. PMID: 26742501
5. Data show that WAC directly binds to GM130 and that this binding is required for autophagosome formation through interacting with GABARAP regulating its subcellular localization. PMID: 26687599
6. Mutagenesis experiments support these structural observations and demonstrate that they are required for GRASP65-GM130 association. PMID: 26363069
7. Depletion of GM130 increases cellular velocity and increases the invasiveness of breast cancer cells, therefore supporting the view that alterations of polarity contribute to tumor progression. PMID: 25892554
8. GM130 is a parallel homotetramer with a flexible rod-like structure with I- and Y-shaped conformations. PMID: 25787021
9. H-ERG trafficking was impaired by H2O2 after 48 h treatment, accompanied by reciprocal changes of expression between miR-17-5p seed miRNAs and several chaperones (Hsp70, Hsc70, CANX, and Golga20) PMID: 24386440
10. Induction of autophagy by shGOLGA2 may induce cell death rather than cell survival. Downregulation of GOLGA2/GM130 may be a potential therapeutic option for lung cancer. PMID: 22735382
11. GM130 is involved in the control of glycosylation, cell cycle progression, cell polarization and directed cell migration, according to this review. PMID: 20197635
12. FXIII-A associated with podosomes & other structures adjacent to the plasma membrane, containing TGN46 & GM130 but not protein disulphide isomerase. FXIII-A was present in GM130-positive intracellular vesicles that could mediate its transport. PMID: 20086247
13. the cytoplasmic C terminus of HERG participates in the tethering or possibly targeting of HERG-containing vesicles within the Golgi via its interaction with GM130 PMID: 12270925
14. Mammalian Ste20 kinases YSK1 and MST4 target to the Golgi apparatus via the Golgi matrix protein GM130. PMID: 15037601
15. Ribbon formation requires the Golgi proteins GM130 and GRASP65. PMID: 16489344
16. This is the first report of a role for a Golgi apparatus protein in the regulation of centrosomes during interphase. PMID: 18045989
17. depletion of GM130 by RNA interference slows the rate of ER to Golgi trafficking in vivo; interactions of GM130 with syntaxin 5 and Rab1 are regulated by mitotic phosphorylation PMID: 18167358
18. Cdc42 has a novel role in controlling centrosome organization in unstimulated cells in addition to its known function as a regulator of centrosome reorientation in stimulated cells. PMID: 19109421
19. Data suggest that recruitment of AKAP450 on Golgi membranes through GM130 allows centrosome-associated nucleating activity to extend to the Golgi, to control the assembly of subsets of microtubules. PMID: 19242490

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HGNC: 4425

OMIM: 602580

KEGG: hsa:2801

STRING: 9606.ENSP00000416097

UniGene: Hs.155827