Recombinant Human Homeobox protein Hox-C6 (HOXC6)

Code CSB-YP010677HU
MSDS
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Source Yeast
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Code CSB-EP010677HU
MSDS
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Source E.coli
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Code CSB-EP010677HU-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP010677HU
MSDS
Size Pls inquire
Source Baculovirus
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Code CSB-MP010677HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
HOXC6
Uniprot No.
Alternative Names
CP25; HHO.C8; Homeo box 3C; Homeo box C6; Homeo box C8 protein; Homeobox C6; Homeobox protein CP25; Homeobox protein HHO.C8; Homeobox protein Hox-3C; Homeobox protein Hox-C6; HOX3; HOX3C; Hoxc6; HXC6_HUMAN
Species
Homo sapiens (Human)
Expression Region
1-235
Target Protein Sequence
MNSYFTNPSL SCHLAGGQDV LPNVALNSTA YDPVRHFSTY GAAVAQNRIY STPFYSPQEN VVFSSSRGPY DYGSNSFYQE KDMLSNCRQN TLGHNTQTSI AQDFSSEQGR TAPQDQKASI QIYPWMQRMN SHSGVGYGAD RRRGRQIYSR YQTLELEKEF HFNRYLTRRR RIEIANALCL TERQIKIWFQ NRRMKWKKES NLTSTLSGGG GGATADSLGG KEEKREETEE EKQKE
Protein Length
Full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Gene References into Functions
  1. our findings indicate that HOXC6 plays an important role in the progress and prognosis of human glioma and promotes glioma U87 cell growth through the WIF-1/Wnt signaling pathway PMID: 30228024
  2. Overall, the data show that miR-185 could negatively target HOXC6 to suppress cell proliferation, promotes apoptosis and autophagy through inhibiting TGF-beta1/mTOR axis in nasopharyngeal carcinoma (NPC). Thus, miR-185 is useful strategy for the treatment of NPC. PMID: 29991129
  3. HOXC6 mRNA levels were shown to be good predictors for the detection of High-grade Prostate Cancer. PMID: 27108162
  4. HOXC6 thus appears to promote colorectal cancer cell proliferation and tumorigenesis through autophagy inhibition PMID: 27081081
  5. Increased expression of HOXC6 in gastric cancer cell lines significantly activated extracellular signalregulated kinase signaling and upregulated MMP9. The HOXC6 gene promotes the proliferation of gastric cancer cells while upregulation of MMP9 promotes migration and invasion of gastric cancer cells. PMID: 27573865
  6. oxidized low-density lipoprotein (Ox-LDL) decreased expression of HOXC-AS1 and HOXC6 in a time-dependent manner PMID: 27574949
  7. HOXC6 has a role in all prostate cancer stages, particularly in prostate cancer cell proliferation. PMID: 26310814
  8. Data demonstrate significant downregulation of HOXC6 in serous ovarian cancer and low protein level is associated with high-grade tumors. PMID: 26046583
  9. Our studies demonstrate that HOXC6, which is a critical player in mammary gland development, is upregulated in multiple cases of breast cancer, and is transcriptionally regulated by E2 and BPA, in vitro and in vivo. PMID: 25725483
  10. HOXC6 can be used as a prognostic marker in esophageal squamous cell carcinoma PMID: 24525058
  11. HOXC6 expression is an important mechanism of chemotherapeutic drug resistance via its regulation of MDR-1 PMID: 22907429
  12. Hoxc6 might contribute to the progression of gastric carcinogenesis and may be a significant predictor of poor survival in patients with gastric cancer after curative operations. PMID: 23581417
  13. HOXC6 is an important mechanism of the anti-apoptotic pathway via regulation of Bcl-2 expression. PMID: 22896703
  14. These studies demonstrated that HOXC6 is an estrogen-responsive gene, and that histone methylases MLL2 and MLL3, in coordination with ERalpha and ERbeta, transcriptionally regulate HOXC6 in an estrogen-dependent manner. PMID: 21683083
  15. proapoptotic repression targets include neutral endopeptidase (NEP) and insulin-like growth factor binding protein-3 (IGFBP-3) PMID: 15637592
  16. HOXC6 increases transcription of S100beta gene in BrdU-induced in vitro differentiation of GOTO neuroblastoma cells into Schwann cells. PMID: 17488478

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Subcellular Location
Nucleus.
Protein Families
Antp homeobox family
Database Links

HGNC: 5128

OMIM: 142972

KEGG: hsa:3223

STRING: 9606.ENSP00000243108

UniGene: Hs.549040

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