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CSF1 Recombinant Monoclonal Antibody

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Datasheet
Code CSB-RA006043MA1HU
Size $49.9
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  • The Binding Activity of Human CSF1 with Anti-CSF1 recombinant antibody
    Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CSF1 protein (CSB-MP006043HU1) at 2 μg/mL can bind Anti-CSF1 recombinant antibody. The EC50 is 4.291-4.988 ng/mL.
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Product Details

Uniprot No.
P09630
Target Names
CSF1
Alternative Names
CP25 antibody; HHO.C8 antibody; Homeo box 3C antibody; Homeo box C6 antibody; Homeo box C8 protein antibody; Homeobox C6 antibody; Homeobox protein CP25 antibody; Homeobox protein HHO.C8 antibody; Homeobox protein Hox-3C antibody; Homeobox protein Hox-C6 antibody; HOX3 antibody; HOX3C antibody; Hoxc6 antibody; HXC6_HUMAN antibody
Species Reactivity
Human
Immunogen
Recombinant Human CSF1 protein
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Monoclonal
Isotype
hIgG1
Clone No.
17F4
Purification Method
Affinity-chromatography
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Recommended Dilution
Application Recommended Dilution
ELISA 1:5000-1:50000
Protocols
ELISA Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Description

Colony-stimulating factor 1, also known as macrophage colony-stimulating factor, plays a central role in regulating the survival, proliferation, and differentiation of mononuclear phagocytes. This cytokine governs macrophage biology across diverse physiological and pathological contexts, from tissue homeostasis and immune responses to tumor microenvironment modulation. Understanding CSF1 signaling pathways has become increasingly important for researchers investigating inflammatory diseases, cancer immunology, and developmental biology.

This recombinant monoclonal antibody against human CSF1, clone 17F4, offers the consistency and reliability that demanding quantitative assays require. Produced using recombinant technology with a defined human IgG1 framework, this antibody provides sequence-level reproducibility between lots, eliminating the variability that can compromise longitudinal studies or assay development efforts. Researchers can confidently establish protocols knowing that performance characteristics will remain stable across future orders.

Functional validation demonstrates robust binding activity in ELISA applications, with the antibody recognizing immobilized human CSF1 protein at concentrations as low as 2 μg/mL. The determined EC50 range of 4.291 to 4.988 ng/mL reflects strong binding affinity suitable for sensitive detection applications. Recommended working dilutions span from 1:5000 to 1:50000, providing flexibility to optimize signal-to-noise ratios across different experimental setups and sample concentrations.

Supplied in a stabilized liquid format containing 50% glycerol in PBS with Proclin 300 preservative, this antibody is ready for immediate use without reconstitution. The affinity-purified preparation ensures minimal background interference. For researchers exploring epigenetics, nuclear signaling, or cytokine biology, this CSF1 antibody delivers the technical performance needed for reliable, reproducible results in immunoassay-based detection workflows.

Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Gene References into Functions
  1. our findings indicate that HOXC6 plays an important role in the progress and prognosis of human glioma and promotes glioma U87 cell growth through the WIF-1/Wnt signaling pathway PMID: 30228024
  2. Overall, the data show that miR-185 could negatively target HOXC6 to suppress cell proliferation, promotes apoptosis and autophagy through inhibiting TGF-beta1/mTOR axis in nasopharyngeal carcinoma (NPC). Thus, miR-185 is useful strategy for the treatment of NPC. PMID: 29991129
  3. HOXC6 mRNA levels were shown to be good predictors for the detection of High-grade Prostate Cancer. PMID: 27108162
  4. HOXC6 thus appears to promote colorectal cancer cell proliferation and tumorigenesis through autophagy inhibition PMID: 27081081
  5. Increased expression of HOXC6 in gastric cancer cell lines significantly activated extracellular signalregulated kinase signaling and upregulated MMP9. The HOXC6 gene promotes the proliferation of gastric cancer cells while upregulation of MMP9 promotes migration and invasion of gastric cancer cells. PMID: 27573865
  6. oxidized low-density lipoprotein (Ox-LDL) decreased expression of HOXC-AS1 and HOXC6 in a time-dependent manner PMID: 27574949
  7. HOXC6 has a role in all prostate cancer stages, particularly in prostate cancer cell proliferation. PMID: 26310814
  8. Data demonstrate significant downregulation of HOXC6 in serous ovarian cancer and low protein level is associated with high-grade tumors. PMID: 26046583
  9. Our studies demonstrate that HOXC6, which is a critical player in mammary gland development, is upregulated in multiple cases of breast cancer, and is transcriptionally regulated by E2 and BPA, in vitro and in vivo. PMID: 25725483
  10. HOXC6 can be used as a prognostic marker in esophageal squamous cell carcinoma PMID: 24525058
  11. HOXC6 expression is an important mechanism of chemotherapeutic drug resistance via its regulation of MDR-1 PMID: 22907429
  12. Hoxc6 might contribute to the progression of gastric carcinogenesis and may be a significant predictor of poor survival in patients with gastric cancer after curative operations. PMID: 23581417
  13. HOXC6 is an important mechanism of the anti-apoptotic pathway via regulation of Bcl-2 expression. PMID: 22896703
  14. These studies demonstrated that HOXC6 is an estrogen-responsive gene, and that histone methylases MLL2 and MLL3, in coordination with ERalpha and ERbeta, transcriptionally regulate HOXC6 in an estrogen-dependent manner. PMID: 21683083
  15. proapoptotic repression targets include neutral endopeptidase (NEP) and insulin-like growth factor binding protein-3 (IGFBP-3) PMID: 15637592
  16. HOXC6 increases transcription of S100beta gene in BrdU-induced in vitro differentiation of GOTO neuroblastoma cells into Schwann cells. PMID: 17488478

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Subcellular Location
Nucleus.
Protein Families
Antp homeobox family
Database Links

HGNC: 5128

OMIM: 142972

KEGG: hsa:3223

STRING: 9606.ENSP00000243108

UniGene: Hs.549040

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