Product Details

Purity

Greater than 85% as determined by SDS-PAGE.

Target Names

KLK9

Uniprot No.

Q9UKQ9

Research Area

Cancer

Alternative Names

(Kallikrein-like protein 3)(KLK-L3)

Species

Homo sapiens (Human)

Source

Mammalian cell

Expression Region

16-250aa

Target Protein Sequence

HGWADTRAIGAEECRPNSQPWQAGLFHLTRLFcGATLISDRWLLTAAHCRKPYLWVRLGEHHLWKWEGPEQLFRVTDFFPHPGFNKDLSANDHNDDIMLIRLPRQARLSPAVQPLNLSQTCVSPGMQCLISGWGAVSSPKALFPVTLQCANISILENKLCHWAYPGHISDSMLCAGLWEG
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Mol. Weight

49.2 kDa

Protein Length

Full Length of Mature Protein

Tag Info

C-terminal hFc1-tagged

Form

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

3-7 business days

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet & COA

Please contact us to get it.

Description

In expressing the recombinant Human KLK9 protein, mammalian cells are transfected with a DNA expression vector that harbors the gene for the desired protein (16-250aa). The cultured cells then express the intended protein. The protein is equipped with a C-terminal hFc tag. The recombinant Human KLK9 protein is collected and purified from the cell lysate through affinity purification, achieving a purity surpassing 85%, as confirmed by SDS-PAGE.

Target Background

Gene References into Functions

Pronounced correlations between KLK10/KLK11 (rs = 0.647) and between KLK9/KLK15 (rs = 0.716) mRNA, but not between other combinations, indicate coordinate expression of distinct pairs of peptidases PMID: 29095848
Data suggest that mature KLK9 (kallikrein 9) is a glycosylated chymotrypsin-like enzyme with strong preference for tyrosine over phenylalanine at P1 cleavage position; substrate specificity of KLK9 appears to extend to KLK10 and midkine; enzyme activity is enhanced by Mg2+ and Ca2+, but is reversibly attenuated by Zn2+; KLK9 is inhibited in vitro by many naturally occurring or synthetic protease inhibitors. PMID: 28559305
Data demonstrate that elevated levels of KLK6, KLK7 and KLK9 proteins are associated with poor glioblastoma patients survival. PMID: 26231762
the serum level has the potential to be used as a biomarker for asthma PMID: 25747782
Observational study of gene-disease association. (HuGE Navigator) PMID: 20424135

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Subcellular Location

Secreted.

Protein Families

Peptidase S1 family, Kallikrein subfamily

Tissue Specificity

Skin, thymus, trachea, cerebellum and spinal cord.

Database Links

HGNC: 6370

OMIM: 605504

KEGG: hsa:284366

STRING: 9606.ENSP00000366028

UniGene: Hs.448942

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Code	CSB-MP892334HU
Abbreviation	Recombinant Human KLK9 protein
MSDS	MSDS Datasheet
Size	$660
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Recombinant Human Kallikrein-9 (KLK9)

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