Recombinant Human La-related protein 7 (LARP7)

1. LARP7 may have inhibited the proliferation and increased the radioiodine uptake of PTC cells by regulating the SHH signaling pathway. PMID: 29620212
2. a structural model for Larp7 binding to the 7SK 3' end and mechanism for 7SK RNP assembly. This work provides insight into how this domain contributes to 7SK recognition and assembly of the core 7SK RNP. PMID: 29946027
3. LARP7 knockdown induces progressive time-dependent telomere shortening concomitant with a reduction in telomerase enzymatic activity and a decrease in full-length (catalytically active) TERT mRNA in vitro, and that humans with LARP7 deficiency display dramatically short telomeres, borderline anemia in younger generations, and anticipation consistent with a telomeropathy. PMID: 27766953
4. The 7SK small nuclear RNP (snRNP), composed of the 7SK small nuclear RNA (snRNA), MePCE, and Larp7, also functions as a canonical transcription factor that, in collaboration with the little elongation complex (LEC) comprising ELL, Ice1, Ice2, and ZC3H8, promotes transcription of RNAPII-specific spliceosomal snRNA and small nucleolar RNA (snoRNA) genes. PMID: 28254838
5. protein HEXIM with 7SKsnRNP complex comprising the non-coding RNA 7SK and proteins MePCE and LARP7. PMID: 25863285
6. results suggest that LARP7 uses both its N- and C-terminal domains to stabilize 7SK in a closed structure, which forms by joining conserved sequences at the 5'-end with the foot of the 3' hairpin and has thus functional implications PMID: 25753663
7. LARP7 suppresses P-TEFb activity to inhibit breast cancer progression and metastasis. PMID: 25053741
8. LARP7 is most likely recruited to the HIV-1 promoter in the presence of hnRNP A1. PMID: 24607481
9. The results demonstrate that the La modules of the human LARP7 is also active in tRNA-mediated suppression, even in the absence of stable UUU-3'OH trailer protection. PMID: 23887937
10. Mediator MED23 regulates basal transcription in vivo via an interaction with P-TEFb. PMID: 23340209
11. Loss of function mutation in LARP7, chaperone of 7SK ncRNA, causes a syndrome of facial dysmorphism, intellectual disability, and primordial dwarfism PMID: 22865833
12. LARP7 downregulation occurs early during gastric tumorigenesis and may promote gastric tumorigenesis via p-TEFb dysregulation. PMID: 22488152
13. 7SK RNA thus establishes gene-dependent plasticity between HMGA1 chromatin remodeling and transcription initiation and P-TEFb transcription elongation. PMID: 21957495
14. A combination of restrictive chromatin structures at the HIV long terminal repeat and limiting P-TEFb levels contribute to transcriptional silencing leading to latency in primary CD4(+) T cells. PMID: 20410271
15. Results identify PIP7S as a La-related protein stably associated with and required for 7SK snRNP integrity. PMID: 18249148
16. Results indicate LARP7 is a 7SK-binding protein. PMID: 18281698
17. Results suggest that LARP7 is a negative transcriptional regulator of polymerase II genes, acting by means of the 7SK RNP system. PMID: 18483487

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HGNC: 24912

OMIM: 612026

KEGG: hsa:51574

STRING: 9606.ENSP00000314311

UniGene: Hs.713663