Purity
Greater than 90% as determined by SDS-PAGE.
Alternative Names
DCMC_HUMAN; hMCD; Malonyl CoA decarboxylase; Malonyl CoA decarboxylase mitochondrial; Malonyl coenzyme A decarboxylase; Malonyl-CoA decarboxylase; MCD; MGC59795; mitochondrial; Mlycd
Species
Homo sapiens (Human)
Expression Region
40-493aa
Target Protein Sequence
MDELLRRAVPPTPAYELREKTPAPAEGQCADFVSFYGGLAETAQRAELLGRLARGFGVDHGQVAEQSAGVLHLRQQQREAAVLLQAEDRLRYALVPRYRGLFHHISKLDGGVRFLVQLRADLLEAQALKLVEGPDVREMNGVLKGMLSEWFSSGFLNLERVTWHSPCEVLQKISEAEAVHPVKNWMDMKRRVGPYRRCYFFSHCSTPGEPLVVLHVALTGDISSNIQAIVKEHPPSETEEKNKITAAIFYSISLTQQGLQGVELGTFLIKRVVKELQREFPHLGVFSSLSPIPGFTKWLLGLLNSQTKEHGRNELFTDSECKEISEITGGPINETLKLLLSSSEWVQSEKLVRALQTPLMRLCAWYLYGEKHRGYALNPVANFHLQNGAVLWRINWMADVSLRGITGSCGLMANYRYFLEETGPNSTSYLGSKIIKASEQVLSLVAQFQKNSKL
Note: The complete sequence including tag
sequence, target protein sequence and linker sequence could be provided upon request.
Protein Length
Full Length of Mature Protein
Tag Info
N-terminal 10xHis-tagged and C-terminal Myc-tagged
Form
Liquid or Lyophilized powder
Note: We will preferentially ship the format that
we have in stock, however, if you have any special requirement for the format, please remark your
requirement when placing the order, we will prepare according to your demand.
Buffer
Tris-based buffer,50% glycerol
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw
cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature
and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized
form is 12 months at -20°C/-80°C.
Lead Time
3-7 business days
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA
Please contact us to get it.
Description
Amino acids 40-493 form the expressed segment for recombinant Human MLYCD. The calculated molecular weight for this MLYCD protein is 55.9 kDa. This MLYCD protein is produced using e.coli expression system. The MLYCD gene fragment has been modified by fusing the N-terminal 10xHis tag and C-terminal Myc tag, providing convenience in detecting and purifying the recombinant MLYCD protein during the following stages.
Human malonyl-CoA decarboxylase (MLYCD) is a mitochondrial enzyme that catalyzes the conversion of malonyl-CoA to acetyl-CoA and carbon dioxide, playing a crucial role in fatty acid metabolism. By reducing malonyl-CoA levels, MLYCD alleviates its inhibitory effect on carnitine palmitoyltransferase 1 (CPT1), thus promoting fatty acid oxidation and mitochondrial energy production. MLYCD deficiency leads to the accumulation of malonyl-CoA, impairing fatty acid oxidation and causing symptoms such as cardiomyopathy, skeletal myopathy, and developmental delay. Research on MLYCD spans various areas, including lipid metabolism, mitochondrial function, and metabolic disorders, aiming to elucidate its role in health and disease and develop potential therapeutic strategies.