Recombinant Human Matrix Gla protein (MGP)

1. Dp-ucMGP was high preoperatively, and further increased postoperatively in cardiovascular risk patients. PMID: 29303985
2. Study found an association between diastolic left ventricular function with circulating inactive desphospho-uncarboxylated MGP in two cohorts; undertook histological studies confirming the presence of MGP in the heart and determining its exact localization in healthy and diseased hearts, using conformation-specific MGP antibodies. PMID: 29529056
3. Studied serum levels of bone morphogenic protein-4 (BMP-4) and matrix Gla protein (MGP) in patients who were admitted to emergency department with the diagnosis of acute coronary syndrome (ACS) and underwent primary percutaneous coronary intervention. MGP and BMP-4 levels were significantly elevated when compared to subjects with normal coronary arteries. PMID: 28605143
4. genetic association studies in population in Greece: Data suggest that an SNP in promoter region of matrix Gla protein (rs1,800,802; T-138C) is associated with diabetic angiopathy (as indicated by carotid intima media thickness) in patients with type 2 diabetes and diabetic nephropathy. PMID: 28734846
5. This study concluded that diabetes coexisting with renal disease leads to extreme vascular calcification expressed by elevated MGP levels, resulting in higher frequency of cardiovascular disease in comparison to CKD patients without diabetes. PMID: 28654853
6. Increased desphospho-uncarboxylated matrix Gla protein, which is a circulating biomarker of vitamin K status and vascular calcification, is independently associated with aortic stiffness, but not with stiffness of distal muscular-type arteries. PMID: 26016598
7. Our results indicate that the association between the matrix Gla protein variant and increased risk for hand Osteoarthritis is caused by a lower expression of matrix Gla protein, which may increase the burden of hand Osteoarthritis by decreased inhibition of cartilage calcification. PMID: 28855172
8. Genetic variability in the MGP gene was associated with vascular recurrence in the Spanish population. PMID: 28411264
9. MGP is significantly repressed by miR-155 in breast cancer MCF-7 cells, and concomitantly there is a stimulation of cell proliferation and cell invasiveness. PMID: 27009385
10. ectopic expression of Mgp in murine and human osteosarcoma cells led to a marked increase in lung metastasis. Abrogation of Mgp prevented lung metastatic activity, an effect that was rescued by forced expression. Mgp levels dramatically altered endothelial adhesion, trans-endothelial migration in vitro and tumour cell extravasation ability in vivo PMID: 27172275
11. MGP rs4236 [A/G] gene polymorphism was not to be associated with subgingival dental calculus. Also, that GCF MGP levels were detected higher in patients with subgingival dental calculus than those without subgingival dental calculus independently of polymorphism, may be the effect of adaptive mechanism to inhibit calculus formation. PMID: 27348051
12. The substitution of threonine by alanine due to MGP exon 4 Thr83Ala polymorphism is related to a decrease in the likelihood of arterial calcification in female persons in the Ukrainian population PMID: 27119839
13. Correlations of plasma desphosphorylated uncarboxylated matrix Gla protein (dp-ucMGP) with vascular calcification and vascular stiffness in chronic kidney disease. Plasma dp-ucMGP was positively associated with vascular calcification and might be utilized as an early marker for vascular calcification in CKD patients. PMID: 27951533
14. circulating dp-ucMGP and dp-cMGP may have a role in increasing risk of all-cause and cardiovascular mortality PMID: 24835435
15. It is assumed that Lp-PLA2 is involved in vascular calcification and that dp-ucMGP is a more appropriate biomarker of residual risk than Lp-PLA2 itself. PMID: 25458708
16. Data shoed increased GAS6 and decreased MGP levels in hemodialysis patients, as mediators of induction or prevention of vascular calcification. PMID: 25957430
17. Altering NOTCH1 levels affected MGP mRNA and protein. PMID: 25871831
18. Uncarboxylated MGP in synovial fluid might serve as a novel biomarker for assessing knee osteoarthritis progression. PMID: 26771974
19. MGP expression is significantly lower in diseased relative to normal aortic valve interstitial cells. Lack of this important "anti-calcification" protein may contribute to calcification of the aortic valve. PMID: 25990696
20. Higher plasma dephosphorylated uncarboxylated MGP (reflective of lower vitamin K status) was associated with higher odds of meniscus damage, osteophytes, bone marrow lesions, and subarticular cysts. PMID: 25528106
21. High levels of desphospho-uncarboxylated MGP are independently and positively associated with arterial stiffness after adjustment for common cardiovascular risk factors, renal function, and age. PMID: 25987667
22. The association has been found between the ischemic atherothrombotic stroke and polymorphic variants of genes MGP and VKORC1. PMID: 26040031
23. MGP expression is impaired in patients with ankylosing spondylitis PMID: 25974989
24. The concentration of dephosphorylated-uncarboxylated Matrix Gla protein was higher in hemodialysis patients treated with vitamin K. PMID: 25190488
25. the findings of this prospective study among type 2 diabetic patients shows that high circulating dpucMGP levels are associated with increased cardiovascular diseases risk, especially with peripheral arterial disease and heart failure. PMID: 23877986
26. Matrix Gla protein gene functional polymorphisms is associated with loss of bone mineral density and progression of aortic calcification. PMID: 24281054
27. Inactive nonphosphorylated and uncarboxylated matrix Gla protein levels were followed in a Flemish population. They correlated causally with non-cancer mortality and coronary events but not total cardiovascular mortality. PMID: 25421980
28. Both mutations predict complete loss of MGP function. PMID: 24458983
29. High matrix Gla protein levels are associated with below-knee arterial calcification score in type 2 diabetes mellitus patients. PMID: 24762216
30. Vitamin K insufficiency, as assessed by high plasma matrix Gla protein concentrations, is associated with increased risk for cardiovascular disease independent of classical risk factors and vitamin D status. PMID: 24210635
31. Based on the study results, the MGP protein did not play an important role in the development of stenosis of coronary arteries. PMID: 24445527
32. The MGP-138CC genotype may be associated with slower progression of vascular calcification in maintenance hemodialysis patients PMID: 23504408
33. High MGP concentrations may be associated with more vascular calcification. PMID: 24029658
34. Higher circulating MGP levels could help identify minor carotid stenosis with calcification in a relatively homogenous risk population (i.e., postmenopausal women), regardless of underlying cardiovascular risk factors PMID: 22992285
35. The A/A-variant of MGP gene is associated with an increased risk of ischemic atherothrombotic stroke in the Ukrainian women. PMID: 24228496
36. rs1800802 (T > C) polymorphism within the MGP promoter is not related to stenosis of the coronary artery. PMID: 23563003
37. Genetic variants of MGP are associated with calcification on the arterial wall. PMID: 23677904
38. Circulating dp-ucMGP and t-ucMGP may serve as markers for the extent of coronary artery calcification, but these findings need to be confirmed PMID: 22819559
39. MGP is a multi-functional inhibitor of normal and abnormal angiogenesis that may function by coordinating with both Notch and BMP signaling pathways PMID: 23110920
40. MGP carboxylation remained much less in pseudoxanthoma elasticum fibroblasts. PMID: 23223140
41. Menaquinone supplementation dose-dependently decreases dephospho-uncarboxylated MGP concentrations, but does not affect other MGP species. PMID: 23062766
42. Increased risk of myocardial infarction associated with MGP ThrAla83 genotype observed elsewhere may be related to faster progression of subclinical coronary atherosclerosis. PMID: 23307874
43. findings showed that SNPrs4236 of the MGP gene is associated with kidney stones in the Chinese Han population, and influences the genetic susceptibility to kidney stones PMID: 23046575
44. the A/A-variant of MGP gene promotor is associated with an increased risk of ischemic atherothrombotic stroke in female persons in the Ukrainian population. PMID: 23233942
45. The change in serum fetuin-A, matrix Gla protein (MGP), and osteopontin (OPN) levels after intracerebral hemorrhage (ICH) indicates that these parameters play a role in the pathophysiological processes leading to an ICH. PMID: 22115341
46. Angiotensin II exacerbates vascular calcification through activation of transcription factors, and regulation of MGP and inflammatory cytokine expression in vascular smooth muscle cells. PMID: 22796540
47. There may be an association between hand osteoarthritis and genetic polymorphism at the matrix Gla protein (MGP) locus that is not reflected by total MGP serum concentrations. PMID: 21724703
48. MGP level correlated negatively with proinflammatory cytokines & acute phase proteins in acute pancreatitis, & positively with lipase, fetuin A, & albumin, indicating a possible role in calcium & phosphate metabolism disturbances in AP. PMID: 22239033
49. a dysregulated MGP system could be involved in left ventricular dysfunction in patients with chronic heart failure PMID: 21294711
50. Mgp gene deletion may have a role in arteriovenous malformations PMID: 21765215

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HGNC: 7060

OMIM: 154870

KEGG: hsa:4256

UniGene: Hs.365706