Recombinant Human Membrane transport protein XK(XK),partial

Code CSB-YP026198HU
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Source Yeast
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Code CSB-EP026198HU
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Source E.coli
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Code CSB-EP026198HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP026198HU
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Source Baculovirus
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Code CSB-MP026198HU
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names XK
Uniprot No. P51811
Alternative Names XK; XKR1; XRG1; Membrane transport protein XK; Kell complex 37 kDa component; Kx antigen; XK-related protein 1
Species Homo sapiens (Human)
Protein Length Partial
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Data

Function May be involved in sodium-dependent transport of neutral amino acids or oligopeptides.
Gene References into Functions
  1. the expression of KX is critical to normal morphology, and null mutations are associated with the McLeod neuroacanthocytosis syndrome. PMID: 26308465
  2. The XK gene was not linked to hypermutability in red cells from patients with paroxysmal nocturnal hemoglobinuria. PMID: 24816235
  3. study reports the clinical findings and a novel nonsense hemizygous mutation, c.154C>T (p.Gln52X) at exon 1 of XK gene in a Taiwanese family with McLeod syndrome PMID: 24635891
  4. Novel XK protein mutations are reported in two patients who exhibit typical clinical characteristics of McLeod syndrome. PMID: 21463873
  5. This study identified one non-synonymous and one intron variant in mood disorder and schizophrenia subjects, respectively, in XK. PMID: 21145924
  6. In human cortex, the results show expression of XK in cortical neurons with an apparent cytoplasmic localization. PMID: 17379193
  7. Sequence analysis demonstrated a 5 bp deletion in exon 2 of the XK gene in McLeod syndrome. PMID: 17469188

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Involvement in disease McLeod syndrome (MLS)
Subcellular Location Membrane, Multi-pass membrane protein
Protein Families XK family
Tissue Specificity High levels in skeletal muscle, heart, brain, and pancreas; low levels in placenta, lung, liver, and kidney.
Database Links

HGNC: 12811

OMIM: 300842

KEGG: hsa:7504

STRING: 9606.ENSP00000367879

UniGene: Hs.78919

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