Recombinant Human Metastasis-associated protein MTA1 (MTA1)

1. Together findings presented here recognize an inherent role of MTA1 as a modifier of DNMT3a and IGFBP3 expression, and consequently, the role of MTA1-DNMT3a-IGFBP3 axis in breast cancer progression. PMID: 28393842
2. Meta-analysis demonstrated that increased MTA1 expression was an effective predictor of a worse prognosis in solid tumor patients. PMID: 30313027
3. MTA1 immunopositivity was significantly associated with progression of gastric cancer, and may be helpful in gastric cancer prognosis. PMID: 29573865
4. MTA1 is closely associated with the occurrence and development of endometriosis. Thus, MTA1 level may be used as a new indicator to predict the progression of endometriosis PMID: 30170442
5. MTA 1 protein may constitute an important prognostic marker in pancreatic cancer and could improve prognosis and treatment. PMID: 28635511
6. High Expressions of MTA1 is associated with epithelial to mesenchymal transition and metastasis in non-small-cell lung cancer. PMID: 28418915
7. MiR-30c and MTA1 abnormally expressed in ovarian cancer (OC), which may be related to metastasis of OC. In MiR-30c as a tumor suppressor gene, its expression in OC could lead to reduced expression of MTA1, which may be one of the mechanisms of metastasis of OC cells. PMID: 28901313
8. Inhibit the metastasis and EMT via MTA1. PMID: 28686969
9. Overexpression of MTA1 could be a marker of poor prognosis in Chinese NSCLC patients, but not in lung cancer or small cell lung cancer. PMID: 29061215
10. MTA1 contributed to neovascularization of residual tumors. Cellular experiments further revealed that MTA1 increased the stability and the expression of HIF-1alpha, and overexpression of MTA1 enhanced tube formation and neovessels of chick embryos. PMID: 28589145
11. Findings illustrate how cancer cells utilize a chromatin remodeling factor to engage a core survival pathway to support its cancerous phenotypes, and reveal new facets of MTA1-SGK1 axis by a physiologic signal in cancer progression. PMID: 28504714
12. Downregulation of miR-30e can increase levels of MTA1 in human hepatocellular carcinoma, and furthermore promote cell invasion and metastasis by promoting ErbB2. PMID: 28288133
13. In subgroup analyses based on study quality and tumor type, MTA1 overexpression was obviously related to clinical parameters, such as lymph node metastasis and TNM stage, and was also associated with prognosis of patients with gastrointestinal or esophageal cancer PMID: 28570554
14. Our findings revealed that miR-183 upregulation and MTA1 gene silence significantly repressed the epithelial-mesenchymal transition, migration and invasion of human pancreatic cancer cells. PMID: 28506766
15. In this study, we aimed to analyze the expression of miR-183 and MTA1 in nasopharyngeal carcinoma tissues and cells; explore the role of miR-183 in NPC cell proliferation, invasion, as well as DDP-induced apoptosis; and investigate the relationship between miR-183 and MTA1 in nasopharyngeal carcinoma cells. PMID: 28631568
16. Metastasis-associated protein-1 expression levels in HPV-infected non-small cell lung cancer tissues correlated positively with tumor stage and nodal metastasis. PMID: 27506865
17. our studies indicate that Curcumin increases the sensitivity of Paclitaxel-resistant non-small-cell lung cancer cells to Paclitaxel through microRNA-30c-mediated MTA1 reduction. Curcumin might be a potential adjuvant for non-small-cell lung cancer patients during Paclitaxel treatment. PMID: 28443468
18. Data show that metastasis associated 1 (MTA1) represses neuronal nitric oxide synthase (nNOS) expression upon oxygen glucose deprivation (OGD)-induced oxidative stress. PMID: 27603575
19. Data indicate a positive correlation between metastasis-associated protein 1 (MTA1) and microRNA miR-22, supporting their inhibitory effect on E-cadherin expression. PMID: 28231399
20. The MTA1 subunit of the nucleosome remodeling and deacetylase complex can recruit two copies of RBBP4/RBBP7. PMID: 27144666
21. Results showed that in the development of colon cancer, MTA1 is linked to certain signal pathways, such as Wnt/Notch/nucleotide excision repair pathways. The findings also suggested that MTA1 demonstrates the closest relationship in a coregulation process with the key molecules AKT1, EP300, CREBBP, SMARCA4, RHOA, and CAD. PMID: 27052252
22. elevated expression of MTA1 was significantly correlated with recurrence, and was an independent risk factor for lymph node metastasis in gastric cancer PMID: 27574100
23. the augmentation of endogenous MTA1 expression during neuronal ischemic injury acts additionally to an endocrinous cascade orchestrating intimate interactions between ERalpha and BCL2 pathways. PMID: 26728277
24. show that AR might be an additional marker for endocrine responsiveness in ER(+) cancers and suggests that blocking MTA1 might be an effective way to inhibit AR/HER2 signaling in ER(-) breast cancer PMID: 27026268
25. Suppression of breast cancer metastasis occurs following miR-421 inhibition of MTA1 expression. PMID: 27583980
26. There is no interaction between IGFBP3 and MTA1 in ESCC, and they are not independent risk factors for esophageal squamous cell carcinoma prognosis. PMID: 27035126
27. Findings highlight MTA1 as a key upstream regulator of prostate tumorigenesis and cancer progression. PMID: 26943043
28. the significance of MTA1 expression in the invasion and metastasis of medulloblastoma PMID: 27323185
29. MTA1 expression is upregulated in tumours compared to normal colon cancer samples. PMID: 27320813
30. High MTA1 expression is associated with osteosarcoma progression. PMID: 26797758
31. The crystal structure reveals an extensive interface between MTA1 and RBBP4. PMID: 27098840
32. Results show that metastasis-associated protein 1 (MTA1) and tyrosine hydroxylase (TH) levels were significantly down-regulated in Parkinson disease (PD) samples as compared with normal brain tissue. PMID: 27044752
33. We revealed a new molecular mechanism of MTA1-mediated invasion and metastasis in lung cancer through downstream target EpCAM, and interfering with EpCAM function may be a novel therapeutic strategy for treatment of MTA1-overexpressing lung carcinoma PMID: 26698569
34. MTA1 plays an important role in Epithelial-to-mesenchymal transition (EMT) to promote metastasis via suppressing E-cadherin expression, resulting in a poor prognosis in MPM. MTA1 is a novel biomarker and indicative of a poor prognosis in MPM patients PMID: 26689197
35. Inhibition of MTA1 by ERalpha contributes to protection hepatocellular carcinoma from tumor proliferation and metastasis PMID: 26503703
36. protein abundance of YB-1 and MTA1, irrespective of DNA or mRNA status, can predict for prostate cancer relapse and uncover a vast underappreciated repository of biomarkers regulated at the level of protein expression. PMID: 25797255
37. RNAi aiming at MTA1 can effectively inhibit the expression of MTA1 in endometrial carcinoma Ishikawa cells PMID: 27048111
38. report demonstrates that miR-125a-3p inhibits the proliferation, migration, and invasion of NSCLC cells through down-regulation of MTA1 PMID: 25998575
39. MTA1 drove a global decondensation of chromatin structure, it changed the expression of only a small proportion of genes. PMID: 25205035
40. MTA1 is associated with the aggressive nature of pituitary tumors and may be a potential therapeutic target in this tumor type. PMID: 25977170
41. MTA1 dysregulation in a subset of salivary gland cancer might promote aggressive phenotypes by compromising the tumor suppressor activity of ERbeta PMID: 26168722
42. MTA1 expression was significantly associated with poor metastasis-free survival in nasopharyngeal carcinoma patients. PMID: 25416046
43. High expression of the MTA1 protein was seen in oral squamous cell carcinoma, and was closely associated with tumor progression and increased tumor angiogenesis. PMID: 25301048
44. MTA1 plays a critical role in regulating the malignant behaviors of small cell lung cancer PMID: 25502548
45. Results show that MTA1 promotes the proliferation of epithelial ovarian cancer cells by enhancing DNA repair. PMID: 25501238
46. the concept of the dynamic nature of corepressor versus coactivator complexes and the MTA1 proteome as a function of time to signal is likely to be generally applicable to other multiprotein regulatory complexes in living systems. PMID: 25344802
47. Taken together, current literature suggests that MTA proteins, especially MTA1, act as a master co-regulatory molecule involved in the carcinogenesis and progression of various malignant tumors PMID: 25374266
48. In this review, we will briefly discuss the researches for the identification and characterization of the mta1 gene, its human counterpart MTA1, and their protein products PMID: 25315816
49. In this review, we described various molecular studies of osteosarcoma, especially associated with MTA1. PMID: 25315817
50. This review focuses on the current knowledge about the function and regulation of MTA1 and MTA3 proteins in gynecological cancer, including ovarian, endometrial, and cervical tumors. PMID: 25319202

Show More

Hide All

HGNC: 7410

OMIM: 603526

KEGG: hsa:9112

STRING: 9606.ENSP00000333633

UniGene: Hs.525629