Recombinant Human Peptidyl-prolyl cis-trans isomerase FKBP5 (FKBP5)

1. Study revealed that genetic variants in neonatal FKBP5 moderate the association between antenatal maternal depressive symptoms and right hippocampal volume but only show a trend for such moderation on amygdala volumes and cortical thickness. PMID: 28975925
2. Our findings suggest that the FKBP5 gene and its epigenetic changes could have influence on morphologic changes of several brain regions involved in emotion regulation, and that this process may be associated with the development of MDD. PMID: 28198448
3. We hypothesize a role for FKBP51 as a prognostic marker for MF and suggest an involvement of this immunophilin in deregulated NF-jB pathway of this CTCL. PMID: 28977697
4. Trauma exposure shapes FKBP5 impact on schizophrenia. PMID: 27552816
5. The present findings suggest that Fkbp5 expression in mesocorticolimbic dopaminergic regions associates with early life stress-mediated sensitivity to alcohol drinking and that FKBP5 genotype interacts with parent-child relationship to influence alcohol drinking. PMID: 27709495
6. Study found that DNA methylation levels in multiple genomic regions of FKBP5, a regulator of glucocorticoid response sensitivity, does not mediate the relationship between childhood maltreatment (CM) and depression symptom severity; also a significant increase in FKBP5 gene expression (GE) levels associated with lifetime major depressive disorder, but found no significant difference in GE levels related to exposure to CM. PMID: 28961425
7. study thus provides support for an association between specific FKBP5 genetic variants and MDD risk PMID: 27601205
8. Methylation of FKBP5 is sensitive to stress exposure and may be a mechanism linking early adversity to long-term health and developmental outcomes. PMID: 29162173
9. The results indicate that individuals with at least one copy of the FKBP5 CATT haplotype (minor alleles) are more vulnerable to traversing the hypothesized internalizing pathway of risk than individuals without this genotypic profile. Findings highlight the importance of FKBP5 genetic variation in the context of early adversity; support the role of mediators of an internalizing pathway to problem drinking. PMID: 29162188
10. FKBP5 methylation mediated the association between early life stress and inhibition-related prefrontal activity. PMID: 29162190
11. Exposure to childhood physical abuse may increase the risk for sub-clinical depressive and anxiety symptoms depending on FKBP5 genetic variability. PMID: 28889074
12. SNPs moderate the association of positive and negative recent life events (LEs) with depressive symptoms, state-anxiety, neuroticism, and social anxiety traits PMID: 29466454
13. In humans, abnormal fear extinction was associated with the TT homozygous genotype of FKBP5 SNPs RS9470080 and RS1360780, and hyperarousal symptoms. Results indicate that FKBP5 confers risk for abnormal fear extinction learning in humans, which may drive the development of arousal symptomatology and ultimately the development of posttraumatic stress disorder. PMID: 28025095
14. It is unlikely that the investigated genetic variants are clinically relevantly associated with depression after diagnosis of cancer. PMID: 28590587
15. These results provide strong evidence of interactions between FKBP5 genotypes and early-life stress, which could pose a significant risk factor for stress-associated disorders such as major depression and post-traumatic stress disorder (PTSD). PMID: 28850857
16. FKBP5 polymorphisms in combination with early life stress exposure predict higher insulin and glucose values in midlife. PMID: 27941579
17. GxE interaction between child maltreatment and FKBP5 on dissociative symptoms in adolescence. PMID: 27760575
18. Children with high attachment insecurity and homozygous FKBP5 minor alleles manifest maladaptive emotion regulation and depressive symptoms. PMID: 27485401
19. This study demonstrated that FKBP5 Messenger RNA Increases After Adolescence in Human Dorsolateral Prefrontal Cortex. PMID: 26805584
20. A novel FKBP5 1V55L mutation is associated with Paget's disease in a Chinese family. Mutant FKBP51V55L promotes osteoclastogenesis. PMID: 28524179
21. A negative correlation between basal levels of FKBP5 methylation and serum cortisol was observed. PMID: 28875708
22. Study found an additive interaction effect between FKBP5's rs1360780 variant and the graph-theoretical metrics of hippocampal connectivity to influence depression risk. Data reveals alterations of the communication patterns between the hippocampus and the rest of the brain in depression, effects potentially driven by overall familial factors (genes plus shared twin environment) and modified by the FKBP5 gene. PMID: 26801675
23. This study demonstrated suggest that FKBP5 in the GR pathway may be a point of vulnerability to early-life adversity, as seen in this group of non-traumatized young adults. PMID: 26632991
24. Psychological stress impaired immediate recall in rs1360780, rs3800373 and rs9296158 allele carriers. PMID: 28002634
25. Association of FKBP5 haplotype with risk of suicide attempt. PMID: 27030168
26. This study provides initial evidence that the risk alleles of the FKBP5 polymorphism are associated with different resting-state activity in a frontotemporal-parietal network, and may point to mechanisms underpinning high-risk carriers' vulnerability to severe stress reactions. PMID: 27754486
27. This review showed a significant genetic association in most studies in FKBP5 with a high rate of attempted suicide. PMID: 27638035
28. Associations between the FKBP5 SNPs, exposure to violence and anxiety in females. PMID: 27448712
29. The rs9470080 polymorphism was associated with physiological anxiety, while rs4713916 polymorphism interacted with maltreatment to influence externalizing traits. PMID: 27315459
30. FKBP51 is primarily localized in mitochondria and hTERT is totally nuclear, upon the onset of oxidative stress, FKBP51 (but not FKBP52) becomes mostly nuclear colocalizing with hTERT, and longer exposure times to peroxide favors hTERT export to mitochondria. PMID: 27233944
31. The results show that the presence of the T allele of the FKBP5 SNP rs1360780 was associated with weight loss after bariatric surgery. Bariatric surgery can interact with genes involved in metabolic regulation, leading to different weight loss outcomes PMID: 27421688
32. The role of FKBP51 in intracellular pathways involved in adaptation is summarized. PMID: 27374865
33. we found no effect of early life trauma on heavy drinking in rs1360780*T-allele carriers, rs1360780*C homozygotes exposed to early life trauma had a lower probability of heavy drinking compared to rs1360780*C homozygotes not exposed to early life trauma (P < 0.01). There exists a developmental period of susceptibility to stress that is moderated by FKBP5 genotype. PMID: 27196697
34. LIF and FKBP51 expression in epithelial cells were the most interesting markers of Airway epithelial cells dysfunction/response to corticosteroid treatment. PMID: 28493984
35. The data of this study show a significant increase in DNA methylation of FKBP5 in peripheral blood mononuclear cells of major depressive disorder patients. PMID: 28246044
36. Knockdown of FKBP51 alleviates neuropathic pain via inhibiting the NF-kappaB signaling in chronic constriction injury rat model. PMID: 28629826
37. we sought to extend prior GxE findings by examining the relation of four FKBP5 SNPs (rs9296158, rs3800373, rs1360780, rs947008), childhood abuse, and lifetime PTSD symptom severity. Results revealed that the four FKBP5 SNPs were associated with PTSD symptom severity in both samples . SNP rs9470080 in the main sample, and all four SNPs in the replication sample interacted with childhood abuse to predict PTSD severity PMID: 27078785
38. Findings suggest that posttraumatic stress disorder (PTSD) phenotypes may be characterized by differences in intracellular signaling transduction processes. The associations of expression of GRalpha and FKBP5 in the glucocorticoid (GC) high-sensitive PTSD subgroup may thereby reflect physiological adaptation to preserve immune-relevant GC signaling. PMID: 27086273
39. Associations between FKBP5 genotype and neurodevelopment; potential interaction between FKBP5 genotype and stress experiences (NICU) in preterm infants. PMID: 28247564
40. The main finding in this study is that Holocaust survivors and their offspring have methylation changes on the same site in a functional intronic region of the FKBP5 gene, a GR-binding sequence in intron 7. PMID: 26410355
41. FKBP51 improves the ability of stromal androgen receptor to predict prostate cancer-specific mortality. PMID: 27718274
42. the interaction between bullying and the FKBP5 haplotype was associated with positive, but not negative, psychotic-like experiences, paranoia, and negative affect PMID: 27389186
43. FKBP5 methylation moderates the associations of FKBP5 genotype and resistant attachment with cortisol reactivity. PMID: 28401840
44. Specific variations in FKBP5 gene increased the risk of attempted suicide. PMID: 28030643
45. FKBP5 variations in combination early life stress predict more pronounced depressive symptoms in midlife. PMID: 26740367
46. Our results confirm that the rs1360780 locus alters FKBP5 expression and further that in trans-fashion this locus affects the expression of other glucocorticoid-regulated genes after a glucocorticoid challenge. The CT exposure appears to be essential for trans-effects of rs1360780 on glucocorticoid-regulated genes. PMID: 27648526
47. findings show that miR-511 is a functional regulator of FKBP5 and can contribute to neuronal differentiation. PMID: 27334923
48. FKBP51 positively controls cell motility by promoting RhoA and ROCK activation, thus revealing a novel role for FKBP51 in cytoskeletal rearrangement and cell migration and invasion. PMID: 28032931
49. Since increased DNA methylation in HSD11B2 and FKBP5 are seen in a minority of bisulfite sequencing clones, these epigenetic changes, and functional consequences, may affect subpopulations of placental cells. PMID: 27013342
50. we propose tumor tissue expression of FKBP51 protein as a reliable prognostic marker for OSCC tumors. PMID: 28218707

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HGNC: 3721

OMIM: 602623

KEGG: hsa:2289

STRING: 9606.ENSP00000338160

UniGene: Hs.407190