Recombinant Human Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (PREX1), partial

1. Authors suggest that control of P-Rex1 activity depends on a highly dynamic interplay among distinct signalling routes and its multisite phosphorylation is controlled by the action of different kinases. PMID: 27788493
2. PREX1 integrates dopamine receptor and phosphoinositide 3-kinase signaling to promote glioblastoma tumor cell invasion. PMID: 28051998
3. There is a significant association in the expression of P-Rex1 and MMP10 in human luminal breast cancer, and their co-expression is indicative of poor prognosis. PMID: 27351228
4. Data suggest that PREX1 and PREX2 share similarities in amino acid sequence, domain structure, activation by PIP(3) [phosphatidylinositol 3,4,5-triphosphate] and G-protein-coupled receptors beta/gamma subunits; expression of PREX1 and PREX2 is altered in many cancers. [REVIEW] PMID: 28710285
5. upon ligation of the T-cell antigen receptor (TCR), the TCR associates with and transactivates CXCR4 via phosphorylation of S339-CXCR4 in order to activate a PREX1-Rac1-signaling pathway that stabilizes interleukin-2(IL-2), IL-4, and IL-10 messenger RNA (mRNA) transcripts. PMID: 28694325
6. data point to multiple mechanisms of PREX1 negative regulation by PAKs within receptor tyrosine kinase and GPCR-stimulated signaling pathways PMID: 27481946
7. PREX1 overexpression reduced staurosporine-induced apoptosis whereas its shRNA knockdown promoted apoptosis in response to staurosporine or the anti-estrogen drug tamoxifen. PMID: 27358402
8. An unexpected role for P-Rex1 and Rac1 activation in the genesis of prostate cancer stem cells and resistance to bevacizumab and sunitinib. PMID: 26923603
9. P-Rex1 contributes to the spatiotemporal localization of type I PKA, which tightly regulates this guanine exchange factor by a multistep mechanism. PMID: 26797121
10. findings suggest a vital role of P-Rex1 signaling in CA1 LTD that is critical for social behavior and cognitive function and offer new insight into the etiology of ASDs PMID: 26621702
11. The P-Rex1-Rac1 interface is critical for Rac1 activation in breast cancer cells. PMID: 26112412
12. P-REX1 promotes both PI3K/AKT and MEK/ERK signaling in breast cancer. PMID: 25284585
13. PREX1 gene promoter hypomethylation is a prognostic marker of poor patient survival. PMID: 25248717
14. Phosphorylation of P-Rex1 at serine 1169 participates in IGF-1R signaling in breast cancer cells. PMID: 23899556
15. Cucurbitacin I also failed to affect the activation of P-Rex1 by heregulin. PMID: 23478800
16. These data suggest that P-Rex1 has an influence on physiological migratory processes, such as invasion of cancer cells, both through effects upon classical Rac1-driven motility and a novel association with RTK signalling complexes. PMID: 23382862
17. Studies indicate relevance of P-Rex1 and P-Rex2a, in breast tumorigenesis, and suggest that the exchange factors Vav2 and Vav3 play synergistic roles in breast cancer by sustaining tumor growth, neoangiogenesis, and metastasis. PMID: 23033535
18. We have identified a novel mechanism for direct activation of P-Rex1 through PP1alpha-dependent dephosphorylation. PMID: 22242915
19. Demonstrate presence of P-Rex1 in platelets as well as its role in platelet secretion and aggregation induced by low-dose agonists for g-protein coupled receptors and by collagen. PMID: 22207728
20. HDACs could regulate P-Rex1 gene transcription by interaction with Sp1 and by region-specific changes in histone acetylation within the P-Rex1 promoter PMID: 21636851
21. Selective activation of Akt1 through mTORC2 and P-Rex1 regulates cancer cell migration, invasion and metastasis. PMID: 21339740
22. study reports the identification of P-Rex1, as a novel mediator in signalling by ErbB/HER receptors; correlation between high P-Rex1 expression and poor patient outcome in breast cancer was found PMID: 21042280
23. SNPs near PREX1 may contribute to T2 Diabetes susceptibility mediated through effects of adiposity in European Americans. PMID: 20650312
24. The P-Rex1 is highly overexpressed in human breast cancers and their derived cell lines, particularly those with high ErbB2 and ER expression. PMID: 21172654
25. P-Rex1 is a critical component for formyl peptide receptor 1-mediated signaling leading to NADPH oxidase activation. PMID: 20074642
26. P-Rex1 is a key element in stromal cell-derived factor-1-induced angiogenic responses and signaling pathway. PMID: 20018810
27. S1P(1) signaling linked to cell migration is facilitated by a functional interaction with P-Rex1 via a mechanism that involves the maintenance of S1P(1) receptors at the cell membrane. PMID: 20036214
28. P-Rex1 appears to be a coincidence detector in PtdIns(3,4,5)P3 and Gbetagamma signaling pathways that is particularly adapted to function downstream of heterotrimeric G proteins in neutrophils. PMID: 11955434
29. P-Rex1 is synergistically activated by PIP(3) and Gbetagamma and may act as a coincidence detector for these signaling molecules PMID: 12123595
30. P-Rex1 is regulated by phosphatidylinositol (3,4,5)-trisphosphate and Gbetagamma subunits PMID: 15545267
31. protein kinase A phosphorylates P-Rex1 andd inhibits the phosphatidylinositiol (3,4,5)-trisphosphate and Gbetagamma-mediated regulation of its activity PMID: 16301320
32. Endogenous P-Rex1 translocates to areas of Rac2 and cytoskeletal activation at the leading edge in response to chemoattractant stimuli in human neutrophils and that this translocation can be negatively modulated by activation of PKA and by cell adhesion. PMID: 17227822
33. P-Rex1 links mTOR signaling to Rac activation and cell migration PMID: 17565979
34. P-Rex1 membrane transport is mediated by G protein betagamma subunits and phosphoinositide 3-kinase PMID: 17698854
35. This study has identified P-Rex1 as a Rac3-guanine nucleotide exchange factor in neuronal cells that localises to, and regulates, actin cytoskeletal dynamics at the axonal growth cone to in turn regulate neurite differentiation. PMID: 18697831
36. P-Rex1-dependent activation of Rac promotes prostate cancer metastasis. PMID: 19305425

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HGNC: 32594

OMIM: 606905

KEGG: hsa:57580

STRING: 9606.ENSP00000361009

UniGene: Hs.153310