Recombinant Human Phospholipid scramblase 1(PLSCR1)

Code CSB-EP018207HU
Product Type Recombinant Protein
Size US$1726
Uniprot No. O15162
Relevance May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. May play a role in the antiviral response of interferon (IFN) by amplifying and enhancing the IFN response through increased expression of select subset of potent antiviral genes. May contribute to cytokine-regulated cell proliferation and differentiation.
Image
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Storage Buffer Tris-based buffer,50% glycerol
Alias Ca(2+)-dependent phospholipid scramblase 1 Erythrocyte phospholipid scramblase MmTRA1b
Species Homo sapiens (Human)
Purity Greater than 90% as determined by SDS-PAGE.
Sequence ESTGSQEQKSGVW
Research Area Microbiology
Source E.coli
Gene Names PLSCR1
Expression Region 1-318aa
Tag Info N-terminal GST-tagged
Mol. Weight 28.4kDa
Protein Description Full Length
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.; FUNCTION
Subcellular Location Cell membrane, Single-pass type II membrane protein, Membrane, Lipid-anchor, Cytoplasmic side, Nucleus
Protein Families Phospholipid scramblase family
Tissue Specificity Expressed in platelets, erythrocyte membranes, lymphocytes, spleen, thymus, prostate, testis, uterus, intestine, colon, heart, placenta, lung, liver, kidney and pancreas. Not detected in brain and skeletal muscle.
Database Links

HGNC: 9092

OMIM: 604170

KEGG: hsa:5359

STRING: 9606.ENSP00000345494

UniGene: Hs.130759

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