Recombinant Human Plasma membrane calcium-transporting ATPase 4 (ATP2B4), partial

1. Data (including data from studies in knockout mice) suggest that renalase functions as a protective plasma protein that reduces pancreatic acinar cell injury and prevents pancreatitis via interactions with plasma membrane calcium ATPase PMCA4b. PMID: 29042438
2. Na+, K+-ATPase and Ca2+-ATPase activity and Na+, K+-ATPase alpha4 and PMCA4 isoform expressions examined in asthenozoospermic men PMID: 28787189
3. study provides evidence for the therapeutic potential of targeting PMCA4 to improve VEGF-based pro-angiogenic interventions. This goal will require the development of refined, highly selective versions of ATA, or the identification of novel PMCA4 inhibitors. PMID: 28684310
4. data suggest that an altered regulation of gene expression is responsible for the reduced RBC-PMCA4b levels that is probably linked to the development of human disease-related phenotypes. PMID: 28216081
5. the ATP2B4 enhancer mediates red blood cell hydration and malaria susceptibility PMID: 28714864
6. Increased plasma membrane abundance of PMCA4b in vemurafenib-treated BRAF mutant cells is associated with enhanced Ca2+ clearance. PMID: 27813079
7. The role of heterozygous variants of ATP2B4 is regulated by HSPG2 protein with transcription factors in bone formation through modulation of calcium signaling. PMID: 28327142
8. RNA sequencing identified a novel ATPase, Ca2+ transporting, plasma membrane 4(ATP2B4)-protein kinase C-alpha (PRKCA) fusion transcript. PMID: 26676968
9. our data show that CD147 interacts via its immunomodulatory domains with PMCA4 to bypass TCR proximal signaling and inhibit IL-2 expression. PMID: 26729804
10. We also nominate a new candidate gene in congenital arrhythmia, ATP2B4, and provide experimental evidence of a regulatory role for variants discovered using this framework. PMID: 26448358
11. p.R268Q mutation in PMCA4 resulted in functional changes in calcium homeostasis in human neuronal cells. This suggests that calcium dysregulation may be associated with the pathogenesis of Familial spastic paraplegia PMID: 25798335
12. The slowly activating PMCA4b isoform produced long-lasting Ca2+ oscillations in response to store-operated Ca2+ entry. PMID: 25690014
13. Mechanism of PMCA4 that creates lipid asymmetry is well understood in terms of ATP hydrolysis; molecular models exist for trajectory taken by phospholipid substrates through the enzyme. [review-like article] PMID: 25233416
14. Calcium dysregulation resulting from a novel missense mutation (c.803G>A, p.R268Q) in the PMCA4 (ATP2B4) gene may be associated with the pathogenesis of familial spastic paraplegia. PMID: 25119969
15. PMCA4 inhibits the activation of the calcineurin/NFAT pathway on VEGF stimulation of endothelial cells, leading to a significant attenuation of VEGF-mediated angiogenesis. PMID: 25147342
16. No significant relationship was detected in the level of expression of the ATP2B4 and ATP5B genes in cancerous and healthy tissues of colorectal cancer patients. PMID: 24583174
17. A significant relationship between ATP2B4 gene expression and the tumor location was detected in patients with rectum tumors. PMID: 24583174
18. a di-leucine-like internalization signal at the C-tail of PMCA4b, is reported. PMID: 23830917
19. The PMCA4b enriched in lipid rafts decreases the local [Ca2+] levels, downregulating the nNOS activity dynamically associated to PMCA4b via Ca2+-dependent PDZ domain-mediated protein- protein interactions. PMID: 23549614
20. An ATP2B4 variant reduces the odds of P. falciparum infection in pregnancy and mitigates the odds of associated maternal anemia. PMID: 23444010
21. High PMCA4 gene expression correlates with high peak bone mass in humans. PMID: 23266958
22. GUSB and ATP2B4 have been validated as a reliable gene combination for Cystic Fibrosis Transmembrane Conductance Regulator gene qPCR data normalization. PMID: 22525089
23. Alternative pathways for association and dissociation of the calmodulin-binding domain of plasma membrane Ca(2+)-ATPase isoform 4b (PMCA4b). PMID: 22767601
24. Genome-wide association study for severe malaria identified a locus on chromosome 1q32 within the ATP2B4 gene, and another locus on chromosome 16q22.2, possibly linked to a neighbouring gene encoding the tight-junction protein MARVELD3 PMID: 22895189
25. The results of this study suggest posttranscriptional regulation of PMCA4 during carcinogenesis. PMID: 22480210
26. The recently emerging role of the plasma membrane calcium/calmodulin dependent ATPase isoform 4 (PMCA4) in regulating calcium signalling, is reviewed. PMID: 21167220
27. PMCA4 is strongly expressed in rabbit CE and its immunolocalization exhibits marked changes in distribution during the wound healing process. PMID: 21139678
28. regulatory domain works independently of its terminal localization and if auto-inhibitory domains PMID: 21073872
29. Data show that the anchors correspond to Phe-1110 and Trp-1093, respectively, in full-length PMCA4b, and the peptide and CaM are oriented in an anti-parallel manner. PMID: 19996092
30. We demonstrate here that, in the early phase of apoptosis, hPMCA4b is cleaved at aspartic acid Asp(1080) in hPMCA4b-transfected COS-7 cells or in HeLa cells that naturally express this protein PMID: 11751908
31. plasma membrane Ca2+ pump 4b/CI binds to Ca2+/calmodulin-dependent membrane-associated kinase CASK PMID: 12511555
32. co-immunoprecipitation, treatment with tyrosine kinase inhibitors and integrin inhibition experiments suggest that FAK is responsible for PMCA4b tyrosine phosphorylation during platelet activation. PMID: 12540962
33. results suggest that a decrease in PMCA4b expression in Meg-01 cells is compensated to maintain normal intracellular calcium levels. PMID: 12944246
34. functional association with RASSF1 indicates a role for PMCA4b in the modulation of Ras-mediated signaling PMID: 15145946
35. residue Asp(170), in the putative "A" domain of human PMCA isoform 4xb, plays a critical role in autoinhibition PMID: 15292209
36. a novel functional interaction between PMCA and calcineurin, suggesting a role for PMCA as a negative modulator of calcineurin-mediated signaling pathways in mammalian cells. PMID: 15955804
37. The characteristics of the fragment of hPMCA4b produced by caspase-3 are reported. PMID: 16080782
38. Although differences in PMCA4 mRNA levels were observed between breast cell lines, they were not of the magnitude observed for PMCA2. PMID: 16216224
39. PMCA4 is a good housekeeping gene for normalization of gene expression for polytopic membrane proteins including transporters and receptors. PMID: 16978418
40. physiological relevance of the interaction between PMCA4b and nNOS and suggests its signaling role in the heart PMID: 17242280
41. PMCA4b is localized in non-filamentous actin complexes in resting platelets by means of PDZ domain interactions and then associates with the actin cytoskeleton during cytoskeletal rearrangement upon platelet activation. PMID: 17393022
42. Compared with the expression of PMCA4b upon platelet maturation, platelets from diabetic patients exhibit similarities with immature megakaryocytes PMID: 17883705
43. platelets in hypertensive patients demonstrated a major increase in plasma membrane Ca(2+)ATPase 4b (PMCA4b) expression when compared with normal controls PMID: 17957572
44. PMCA4 seems to be preferentially distributed in both human syncytiotrophoblast plasma membranes. PMID: 18657858
45. Results suggest that PSD-95 promotes the formation of high-density PMCA4b microdomains in the plasma membrane and that the membrane cytoskeleton plays an important role in the regulation of this process. PMID: 19073225
46. Pmca4b likely reduces the local Ca2+ signals involved in reactive cardiomyocyte hypertrophy via calcineurin regulation. PMID: 19287093
47. PMCA4 is significantly (P < 0.000001) downregulated early in the progression of some colon cancers as these cells become less differentiated PMID: 19755660
48. This protein has been found differentially expressed in patients with schizophrenia. PMID: 19034380

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HGNC: 817

OMIM: 108732

KEGG: hsa:493

STRING: 9606.ENSP00000350310

UniGene: Hs.343522