Recombinant Human Properdin (CFP)

1. In conclusion, we challenge the view of properdin as a pattern recognition molecule by providing evidence that it binds to different exogenous and endogenous molecular patterns in only a C3-dependent manner. PMID: 28069958
2. data indicate that properdin enhances platelet/granulocyte aggregates (PGAs) formation via increased production of C5a, and that inhibition of properdin function has therapeutic potential to limit thromboinflammation in diseases characterized by increased PGA formation PMID: 27183616
3. this study shows that RNA interference of properdin in dendritic cells decreased alloantigen-specific T-cell proliferation PMID: 28105653
4. studies demonstrate an essential role of properdin oligomerization in vivo while our monomers enable detailed structural insight paving the way for novel modulators of complement. PMID: 28264884
5. P serum level expression could be a reliable clinical biomarker to identify patients with underlying surface alternative pathway C5 convertase dysregulation. PMID: 26660535
6. can directly interact with neutrophil myeloperoxidase resulting in activation of alternative pathway of complement PMID: 24355864
7. In the pathogenesis of renal tubular damage, P can directly bind to PTECs and may accelerate AP activation by surpassing fH regulation PMID: 24885016
8. Our data show that physiological forms of human properdin bind directly to human platelets after activation by strong agonists in the absence of C3 PMID: 23677468
9. Factor h and properdin recognize different epitopes on renal tubular epithelial heparan sulfate. PMID: 22815489
10. Properdin released from human polymorphonuclear cells does not bind to zymosan or E. coli, but when incubated in properdin-depleted serum this form of properdin binds efficiently to both substrates in a strictly complement C3-dependent manner. PMID: 22851705
11. Properdin and SC5b-9 may be novel biomarkers for future risk of type 2 diabetes in this high-risk population and warrant further investigation. PMID: 22338105
12. Immune human serum that contained bactericidal Abs directed against the 2C7 lipooligosaccharide epitope required functional properdin to kill C4BP-binding strains, but not C4BP-nonbinding strains. PMID: 22368277
13. report a large Finnish family with a novel mutation in the properdin gene. The mutation is located in exon 9 and changes guanine to adenine at nucleotide 1164 (c.1164G>A) that causes tryptophan to change to a premature stop codon (W388X). PMID: 22229731
14. tubular HS as a novel docking platform for alternative pathway activation via properdin, which might play a role in proteinuric renal damage. PMID: 21135110
15. levels of properdin are not associated with childhood wheezing and atopy PMID: 20337960
16. Human properdin can selectively recognize surfaces and enhance or promote alternative pathway of complement activation. PMID: 20382442
17. The conventional mechanism of properdin function is to bind to and stabilize alternative pathway C3 convertases on the surface of Neisseria meningitidis and N. gonorrhoeae. PMID: 20530262
18. Properdin presence is associated with increased SC5b-9 excretion and worse renal function. PMID: 19934084
19. CFP does not seem to confer any risk for age-related macular degeneration. PMID: 20122735
20. A splice site mutation in exon 10 (c.1487-2A>G) was found in the properdin gene and co segregated with biochemically measured properdin deficiency. PMID: 16337490
21. study reports properdin binds predominantly to late apoptotic & necrotic cells but not to early apoptotic cells; binding occurs independently of C3b PMID: 18490764
22. The human complement protein properdin binds to early apoptotic T cells and initiates complement activation, leading to C3b opsonization and ingestion by phagocytic cells. PMID: 18579773
23. The contribution of properdin is pivotal in proteinuria-induced tubular complement activation and subsequent damage. Interference with properdin binding to tubular cells may provide an option for the treatment of proteinuric renal disease. PMID: 18753294
24. Properdin induces the formation of platelet-leukocyte aggregates via leukocyte activation, linking the complement system & platelet-leukocyte aggregates with potential significance in atherosclerotic vascular disease. PMID: 18791942
25. Significantly more transcripts encoding alternative pathway components factor B, C3 and properdin, and C3a receptor and C5a receptor were detected in grade 3 versus grade 0 or 1 biopsies of human cardiac allografts. PMID: 19005416
26. Factor P was expressed in 50% of choroidal neovascular membranes of patients with age-related macular degeneration(AMD). Additional studies need to investigate role of Factor P in development of AMD for potential therapeutic intervention. PMID: 19584655

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HGNC: 8864

OMIM: 300383

KEGG: hsa:5199

STRING: 9606.ENSP00000247153

UniGene: Hs.53155