Purity
Greater than 90% as determined by SDS-PAGE.
Alternative Names
Beta trace protein; Beta-trace protein; Cerebrin 28; Cerebrin-28; glutathione independent PGD synthase; Glutathione independent PGD synthetase; Glutathione-independent PGD synthase; L PGDS; Lipocalin type prostaglandin D synthase; Lipocalin-type prostaglandin-D synthase; LPGDS; PDS; PGD2; PGD2 synthase; PGDS; PGDS2; prostaglandin D synthase; prostaglandin D2 synthase (21 kDa; brain); prostaglandin D2 synthase (brain); prostaglandin D2 synthase 21kDa (brain); Prostaglandin D2 synthase; prostaglandin H2 D isomerase; Prostaglandin-D2 synthase; Prostaglandin-H2 D-isomerase; PTGDS; PTGDS_HUMAN; RP23-47P18.11-006
Species
Homo sapiens (Human)
Expression Region
23-190aa
Target Protein Sequence
APEAQVSVQPNFQQDKFLGRWFSAGLASNSSWLREKKAALSMCKSVVAPATDGGLNLTSTFLRKNQCETRTMLLQPAGSLGSYSYRSPHWGSTYSVSVVETDYDQYALLYSQGSKGPGEDFRMATLYSRTQTPRAELKEKFTAFCKAQGFTEDTIVFLPQTDKCMTEQ
Note: The complete sequence including tag
sequence, target protein sequence and linker sequence could be provided upon request.
Protein Length
Full Length of Mature Protein
Tag Info
N-terminal 6xHis-SUMO-tagged
Form
Liquid or Lyophilized powder
Note: We will preferentially ship the format that
we have in stock, however, if you have any special requirement for the format, please remark your
requirement when placing the order, we will prepare according to your demand.
Buffer
If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the
glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer,
6% Trehalose, pH 8.0.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw
cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature
and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized
form is 12 months at -20°C/-80°C.
Lead Time
3-7 business days
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA
Please contact us to get it.
Description
The expression region of this recombinant Human PTGDS covers amino acids 23-190. The calculated molecular weight for this PTGDS protein is 34.7 kDa. Expression of this PTGDS protein is conducted in e.coli. The PTGDS coding gene included the N-terminal 6xHis-SUMO tag, which simplifies the detection and purification processes of the recombinant PTGDS protein in following stages of expression and purification.
Prostaglandin-H2 D-isomerase (PTGDS) is an enzyme involved in the biosynthesis of prostaglandin D2 (PGD2). PTGDS belongs to the lipocalin protein family and is primarily expressed in the central nervous system, particularly in the brain and cerebrospinal fluid. The main function of PTGDS is the isomerization of PGH2 to PGD2, which plays a role in various physiological processes, including inflammation and sleep regulation. PGD2 is associated with sleep-wake cycles, and PTGDS has been implicated in sleep-related functions. Additionally, PTGDS has been studied in the context of neuroinflammation, and neurodegenerative diseases, and as a potential biomarker for certain neurological conditions. Understanding the role of PTGDS in prostaglandin metabolism and its broader implications in neurological processes is essential for unraveling its potential therapeutic applications and furthering knowledge of neurobiology.
