Product Details

Purity

Greater than 90% as determined by SDS-PAGE.

Target Names

DLK2

Uniprot No.

Q6UY11

Research Area

Signal Transduction

Alternative Names

AI413481; Delta like 2 homolog; Delta like protein 2; delta-like 2 homolog (Drosophila); DLK 2; DLK-2; Dlk2; DLK2_HUMAN; EGF like domain containing protein 9; EGF like domain multiple 9; EGF-like protein 9; EGFL 9; EGFL9; Epidermal growth factor-like protein 9; MGC111055; MGC2487; Multiple EGF like domain protein 9; OTTHUMP00000016449; OTTHUMP00000016451; Protein delta homolog 2

Species

Homo sapiens (Human)

Source

E.coli

Expression Region

27-306aa

Target Protein Sequence

DDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERCVRMPGCQHGTCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELVLPVPDPPTTVDTPLGPTSAVVVPATGPAPHSAGAGLLRISVKEVVRRQEAGLGEPS
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Mol. Weight

56.8kDa

Protein Length

Extracellular Domain

Tag Info

N-terminal GST-tagged

Form

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

3-7 business days

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet & COA

Please contact us to get it.

Description

The region for expressing recombinant Human DLK2 contains amino acids 27-306. This DLK2 protein is theoretically predicted to have a molecular weight of 56.8 kDa. This DLK2 recombinant protein is manufactured in e.coli. Fusion of the N-terminal GST tag into the DLK2 encoding gene fragment was conducted, allowing for easier detection and purification of the DLK2 protein in subsequent stages.

Human protein delta Homolog 2 (DLK2) is a transmembrane protein involved in various developmental processes. It is mainly involved in the regulation of cell differentiation, particularly in adipogenesis and osteogenesis. Investigation of DLK2 provides insights into developmental processes, stem cell biology, and tissue regeneration, offering potential applications in regenerative medicine, tissue engineering, and understanding the molecular mechanisms governing cell fate determination in various tissues. In developmental biology, DLK2 plays a role in tissue patterning and organogenesis. In stem cell research, DLK2 is implicated in the maintenance of pluripotency and differentiation potential. Additionally, DLK2 is associated with the Notch signaling pathway, influencing cell fate decisions.

Target Background

Function

Regulates adipogenesis.

Gene References into Functions

Studies in mouse showed that dlk2, highly homologous to dlk1 (also known as pref-1, and FA-1) appears to modulate adipogenesis in vitro in an opposite way to that of dlk1. PMID: 17320102

Subcellular Location

Membrane; Single-pass type I membrane protein.

Database Links

HGNC: 21113

KEGG: hsa:65989

STRING: 9606.ENSP00000349893

UniGene: Hs.337251

Code	CSB-EP751023HU
Abbreviation	Recombinant Human DLK2 protein, partial
MSDS	MSDS Datasheet
Size	$224
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Image	(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Recombinant Human Protein delta homolog 2 (DLK2), partial

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