Recombinant Human Protein kinase C iota type (PRKCI)

1. Results show a correlation was found between the overexpression of aPKClambda/iota and the degree of pathological differentiation in oral squamous cell carcinoma (OSCC). The nuclear localization of aPKClambda/iota was associated with progression-free survival of OSCC. Overall, the expression and localization of aPKClambda/iota may be involved in the degree of malignancy in OSCC, which is related to prognosis. PMID: 30396949
2. We also carried out PKC-iota and PKC-zeta directed siRNA treatments to prove the above observations. Immunoprecipitation data suggested an association between PKC-iota and vimentin and PKC-iota siRNA treatments confirmed that PKC-iota activates vimentin by phosphorylation. These results further suggested that PKC-iota is involved in signaling pathways which upregulate EMT and which can be effectively suppressed using A... PMID: 29048609
3. These results indicate that PKCiota/lambda is dispensable for Cdc42-triggered processes and for thrombosis and hemostasis in mice. PMID: 28739484
4. 14-3-3zeta and aPKC-iota synergistically facilitate EMT of CCA via GSK-3beta/Snail signalling pathway. PMID: 27409422
5. In human ovarian cancers, high PRKCI expression correlates with high expression of TNFalpha and YAP1 and low infiltration of cytotoxic T cells PMID: 28698296
6. promotes epithelial-mesenchymal transition and induces immunosuppression through the aPKC-iota/P-Sp1/Snail signaling pathway in cholangiocarcinoma PMID: 28574228
7. Polarity signaling via CDC42/atypical protein kinase C can affect the dynamic turnover of the intermediate filament network to promote the polarization of the network itself. PMID: 28432079
8. a PI3K/PKCiota/cyclin E signaling pathway as a therapeutic target during ovarian tumorigenesis PMID: 26279297
9. results identify a novel role of PHLPP in regulating aPKC and cell polarity. PMID: 27760826
10. the polarity function of PRKCI during cavitation PMID: 27312576
11. 14-3-3zeta-mediated invasion of cancer cells was found to upregulate Snail through the activation of atypical protein kinase C (aPKC). PMID: 27554601
12. Upregulated expression of PRKCI and interaction with CDK7 is associated with esophageal squamous cell carcinoma. PMID: 27481515
13. This is the first report on the relationship between aPKC[lambda]/[iota] expression patterns and cervical intraepithelial neoplasia progression or regression. PMID: 26535980
14. the results revealed that PRKCI rs546950 variant decreased the risk of prostate cancer in an Iranian population PMID: 26475383
15. effects. Further studies indicated that PRKCI knockdown-mediated autophagy was associated with the inactivation of phosphatidylinositol 3-kinase alpha/AKT-mammalian target of rapamycin (PIK3CA/AKT-MTOR) signaling. PMID: 26792725
16. the knockdown of aPKC increases and extends TGFbeta-induced p38 MAPK activation, which sensitizes NSCLC cells to undergo apoptosis. PMID: 25501807
17. PKCiota binds to Rab14 and that PKCiota requires Rab14 for its correct distribution in cells. As with Rab14, PKCiota protects claudin-2 from lysosomal degradation and, in consequence, modulates epithelial barrier. PMID: 25694446
18. Constitutive expression of BAG-1M decreased levels of phosphorylated aPKC. PMID: 24876225
19. The results indicate that induction and activation of PKClambda promote TNBC growth, invasion and metastasis. PMID: 24786829
20. Targeting aPKC disables oncogenic signaling by both the EGFR and the proinflammatory cytokine TNFalpha in glioblastoma. PMID: 25118327
21. PRKCI expression is linked with factors pointing to worse prognosis, higher HER2 levels and a lower survival rate in breast cancer. PMID: 24603690
22. These data indicates the existence of a SDF-1alpha induced DGKalpha - atypical PKC - beta1 integrin signaling pathway, which is essential for matrix invasion of carcinoma cells. PMID: 24887021
23. PKCiota gene amplification is correlated with gender, subtype and distant metastasis in Chinese patients with non-small cell lung cancer. PMID: 24636699
24. Suggest that aPKCiota could be an important bio-marker of tumor epithelial-mesenchymal transition, and used as an indicator of invasion and malignancy in hepatocellular carcinoma. PMID: 24651432
25. PKCiota positively regulated beta-catenin through negatively regulated autophagy and depletion of PKCiota promoted apoptosis via autophagic degradation of beta-catenin in esophageal cancer cells. PMID: 23359356
26. Data demonstrate that PKCiota is required for a tumor-initiating cell phenotype in ovarian cancer. PMID: 24174471
27. Report up-regulation of MT1-MMP and atypical protein kinase C in hormone receptor-negative breast tumors in association with a higher risk of metastasis. Silencing of aPKC impaired delivery of MT1-MMP from storage compartments and inhibited invasion. PMID: 24753582
28. It regulates progression of lung adenocarcinoma. PMID: 24318287
29. The PRKCI and SOX2 oncogenes are coamplified and cooperate to activate Hedgehog signaling in lung squamous cell carcinoma. PMID: 24525231
30. The R471C substitution is a change-of-function mutation acting at this substrate-specific recruitment site to selectively disrupt the polarizing activity of PKCiota. PMID: 24045153
31. PKCiota knockdown sensitized cells to oxidative stress-induced apoptosis, whereas forced PKCiota expression counteracted the oxidative stress-induced apoptosis via Hsc70. PMID: 23224638
32. site-specific Dvl2 phosphorylation is required for Dvl2 association with PKCiota; this interaction is likely to be one of the mechanisms essential for Wnt3a-dependent neurite outgrowth PMID: 23396968
33. Morg1 facilitates Par6-aPKC binding to Crb3 for definition of apical identity of epithelial cells. PMID: 23439680
34. results demonstrate that aPKC-iota/lambda is critical for hedgehog-dependent processes and implicates aPKC-iota/lambda as a new, tumour-selective therapeutic target for the treatment of smoothened-inhibitor-resistant cancers PMID: 23446420
35. protein kinase C iota as a therapeutic target in alveolar rhabdomyosarcoma PMID: 22349825
36. In summary, the PI3K/PKCiota regulates the alternative splicing of Bcl-x pre-mRNA with implications in the cell survival of NSCLC cells. PMID: 22522453
37. It was concluded that protein kinase C iota is overexpressed in a subset of cancers where the enzyme functions to suppress premature senescence. This function appears to be restricted to cancer cells. PMID: 22120720
38. glioma cells may be proliferating through a novel PI (3)-kinase-/PKC-iota/Cdk7/cdk2-mediated pathway. PMID: 22021906
39. atypical protein kinase C phosphorylates Numb to prevent its binding to p120 and alpha-adaptin, thereby attenuating E-cadherin endocytosis to maintain apicobasal polarity PMID: 21775625
40. Changes in PKC iota, PKC zeta, and non-muscle MyoIIA expression are likely to participate in pathogenesis of epithelial barrier function in response to local pro-inflammatory signals. PMID: 21667320
41. aPKClambda/iota-IL-6 axis is a reliable prognostic factor for the biochemical recurrence of this cancer. PMID: 21535317
42. Report a willin(FRMD6)/Par3-aPKC-ROCK pathway that controls epithelial apical morphology. PMID: 21685893
43. An association with prostate cancer risk for two SNPs belonging to PRKCI, a gene which is frequently overexpressed in various neoplasms, including prostate cancer. PMID: 21373201
44. The results strongly support the notion that KIBRA regulates epithelial cell polarity by suppressing apical exocytosis through direct inhibition of aPKC kinase activity in the PAR3-aPKC-PAR6 complex. PMID: 21497093
45. PKCiota promotes tumorigenicity and metastasis of human esophageal cancer and that SKP2 is a candidate downstream effector of PKCiota signaling in ESCC. PMID: 21310827
46. Data suggest that glioma cell survival occurs through a PI(3)-kinase/PDK1/PKC-iota/BAD mediated pathway. PMID: 21419810
47. Data conclude that Par6B and aPKC control mitotic spindle orientation in polarized epithelia and, furthermore, that aPKC coordinately regulates multiple processes to promote morphogenesis. PMID: 21300793
48. a model in which PKCiota-mediated phosphorylation regulates Ect2 binding to the oncogenic PKCiota-Par6 complex thereby activating Rac1 activity and driving transformed growth and invasion. PMID: 21189248
49. PKCiota is required for the transformed phenotype of lung, pancreatic, ovarian, prostate, colon, and brain cancer cells. PMID: 20945390
50. PKCiota has a role in both glioblastoma invasion and proliferation, two key aspects in the malignant nature of this disease PMID: 20815904

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HGNC: 9404

OMIM: 600539

KEGG: hsa:5584

STRING: 9606.ENSP00000295797

UniGene: Hs.478199