Recombinant Human Pulmonary surfactant-associated protein A2 (SFTPA2)

1. SP-A1 6A4 and SP-A2 1A5 genetic variants may influence the susceptibility to respiratory distress syndrome in late-preterm infants, independently of the effect of other perinatal factors. PMID: 27835691
2. Significant differences in frequency of occurrence of unfavorable genotypes CC rs1965708, AA rs1059046 of SFTPA2 gene and CC rs1130866 of SFTPB gene in influenza patients in comparison with individuals of the control group were not detected. PMID: 26950992
3. In a Dutch cohort study of unrelated patients with idiopathic or familial interstitial pneumonia genetic analysis of SFTPA2 three new mutations in exon 6 of SFTPA2: N210T, G231R, and N171Y were identified. None were found in the control group. PMID: 26568241
4. Investigated the relationship between SP-A2 and SP-B gene polymorphisms and respiratory distress syndrome in preterm neonates. PMID: 26061924
5. Expression of SFTPA2 mRNA and total SP-A protein was significantly lower in cancer tissue. PMID: 25514367
6. In this study, the loci and haplotypes associated with pulmonary tuberculosis (PTB) were found mostly to be located in the SFTPA2 gene, suggesting that the effects of the SFTPA2 gene on PTB are stronger than those of SFTPA1. PMID: 24984162
7. Genetic variation in SP-A2 leads to differential binding to Mycoplasma pneumoniae membranes and regulation of host responses. PMID: 25957169
8. data suggest an effect of genetic variants of SFTPA2 on the severity of pandemic H1N1 infection PMID: 24950659
9. This study shows that changes occur in the alveolar macrophage proteome in response to a single in vivo treatment with exogenous SP-A1 and/or SP-A2. PMID: 24954098
10. In this review, we highlight the associations of eosinophilic lung diseases with SP-A and SP-D levels and functions. PMID: 24960334
11. sequence variability at the 3'UTR of SFTPA1 and SFTPA2 gene variants differentially affects miRNA regulation of gene expression. PMID: 24793167
12. The aim of this report is to describe the genetic complexity of the SFTPA1 and SFTPA2 genes, as well as to review regulatory mechanisms that control SP-A expression in humans and other animal species.[review] PMID: 23069847
13. findings show rs1650232 is in partial linkage disequilibrium with known SP-A2 marker single-nucleotide polymorphisms previously associated with risk for respiratory diseases including tuberculosis PMID: 23328842
14. proteins including the 14-3-3 family bind two cis-elements within exon B of hSP-A2 mRNA in a sequence- and secondary structure-specific manner. PMID: 23525782
15. SP-A2 G231V and F198S mutants impair the dimmer/trimer assembly, which contributes to the protein sialylation and secretion deficiency. The intracellular protein mutants could be partially degraded through the proteasome pathway and formed aggregates PMID: 23056344
16. Surfactant protein A associated with respiratory distress syndrome in Korean preterm infants: evidence of ethnic difference. PMID: 23038062
17. The untranslated exon B of human surfactant protein A2 mRNAs is an enhancer for transcription and translation. PMID: 21840962
18. there is an association of risk for severe acute respiratory syncytial infection in variant forms of the surfactant protein A2 allele PMID: 21601013
19. These results indicate that the gene polymorphism at the residue 223 in the carbohydrate recognition domain of SFTPA2 may be a genetic marker for the development of allergic rhinitis in the adult Chinese Han population. PMID: 20963503
20. The mechanism of pulmonary fibrosis does not involve an overt lack of secreted SP-A but instead involves an increase in endoplasmic reticulum stress of resident type II alveolar epithelial cells. PMID: 20466729
21. Observational study of gene-disease association. (HuGE Navigator) PMID: 20448439
22. Electron microscopy analysis revealed that hTG mice with a single SP-A1(6A(4)) or SP-A2(1A(3)) gene product lacked tubular myelin (TM), but hTG mice carrying both had TM. PMID: 20048345
23. SP-A2 polymorphisms are associated with the severity of respiratory syncytial virus infection in infants PMID: 19914637
24. Decreased levels of SP-A and SP-D have been measured in bronchoalveolar lavage fluid of these patients, as well as patients with acute pneumonia but no chronic lung disease. (review) PMID: 16406431
25. We conclude that SP-A permeabilizes phospholipid membranes in an LPS-dependent and rough LPS-specific manner, that the effect is neither SP-A- nor species-specific, and that oxidative damage to SP-A abolishes its membrane destabilizing properties PMID: 16489761
26. Residue 85 plays an important role in the structure and function of SP-A and is a major factor for the differences between SP-A1 and SP-A2 variants. PMID: 17580966
27. TTF-1 response element is critical for temporal and spatial regulation and necessary for hormonal regulation of human surfactant protein-A2 promoter activity PMID: 18487360
28. The amniotic fluid concentration of SP-A decreases in spontaneous human parturition at term. PMID: 18828058
29. These data are consistent with SFTPA2 germline mutations that interfere with protein trafficking and cause familial IPF and lung cancer. PMID: 19100526
30. SP-A1 and SP-A2, in addition to their roles in surfactant-related functions, play an important role in the modulation of lung host defense. PMID: 19392648
31. Observational study of gene-disease association. (HuGE Navigator) PMID: 16385451
32. Observational study of gene-disease association. (HuGE Navigator) PMID: 19543369
33. Observational study of gene-disease association. (HuGE Navigator) PMID: 18983439

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HGNC: 10799

OMIM: 178500

KEGG: hsa:729238

STRING: 9606.ENSP00000361400

UniGene: Hs.523084