Recombinant Human R-spondin-3 (RSPO3)

1. Knockdown of RSPO3 resulted in significantly increased mRNA expression levels of RUNX2, ALP and OCN and no effects on the proliferation of human adipose-derived stem cells. PMID: 28220828
2. For liver transplant-free survival, a genome-wide significant signal was identified and expression of the candidate gene RSPO3 was demonstrated in key liver-resident effector cells and may play a role in primary sclerosing cholangitis disease progression. PMID: 28779025
3. The present study identified RSPO fusion transcripts, including three novel transcripts, in one-third of colorectal Traditional serrated adenoma (TSA) and showed that PTPRK-RSPO3 fusions were the predominant cause of RSPO overexpression in colorectal TSA. PMID: 28543708
4. RSPOs facilitate HSC activation and promote liver fibrogenesis by enhancing the Wnt pathway PMID: 27572318
5. Colorectal cancer cell lines identified VACO6 cells as a carrier of a canonical PTPRK(e1)-RSPO3(e2) fusion; cell line displayed marked in vitro and in vivo sensitivity to WNT blockade by the porcupine inhibitor LGK974. Long-term treatment of VACO6 cells with LGK974 led to the emergence of a resistant population carrying two frameshift deletions of the WNT pathway inhibitor AXIN1, with consequent protein loss. PMID: 28100566
6. Using C-mannosylation-defective Rspo3 mutant-overexpressing cell lines, we found that C-mannosylation of Rspo3 promotes its secretion and activates Wnt/beta-catenin signaling. PMID: 27350215
7. High RSPO3 expression is associated with breast cancer. PMID: 26735887
8. A genome-wide association study of bone mineral density (BMD) found a new BMD locus that harbors the PTCH1 gene, that associates with reduced spine BMD and the RSPO3 associates with increased spine BMD. PMID: 26733130
9. results suggest that the expression of RSPO fusion transcripts is related to a subset of colorectal cancers arising in the Japanese population PMID: 24847761
10. using RNA-seq data, identification of multiple fusion transcripts including recurrent gene fusions involving R-spondin family members RSPO2 and RSPO3 that together occur in 10% of colon tumours PMID: 22895193
11. the gene is a novel member of thrombospondin type I repeat supergene family (hPWTSR) PMID: 12463421
12. a polymorphism in thrombospondin subtly but significantly sensitizes the calcium-binding repeats to removal of Ca2+ and thermal denaturation PMID: 12643280

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HGNC: 20866

OMIM: 610574

KEGG: hsa:84870

STRING: 9606.ENSP00000349131

UniGene: Hs.135254