Recombinant Human RNA-binding protein Musashi homolog 2(MSI2)

Code CSB-YP836197HU
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Source Yeast
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Code CSB-EP836197HU
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Source E.coli
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Code CSB-EP836197HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP836197HU
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Source Baculovirus
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Code CSB-MP836197HU
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names MSI2
Uniprot No. Q96DH6
Alternative Names FLJ36569; MGC3245; Msi2; MSI2/HOXA9 fusion gene, included; MSI2H; MSI2H_HUMAN; Musashi 2; Musashi homolog 2; Musashi RNA binding protein 2; Musashi, Drosophila, homolog of, 2; Musashi-2; RNA binding protein Musashi homolog 2; RNA-binding protein Musashi homolog 2; WD 40 repeat protein MSI2
Species Homo sapiens (Human)
Expression Region 1-328
Target Protein Sequence MEANGSQGTS GSANDSQHDP GKMFIGGLSW QTSPDSLRDY FSKFGEIREC MVMRDPTTKR SRGFGFVTFA DPASVDKVLG QPHHELDSKT IDPKVAFPRR AQPKMVTRTK KIFVGGLSAN TVVEDVKQYF EQFGKVEDAM LMFDKTTNRH RGFGFVTFEN EDVVEKVCEI HFHEINNKMV ECKKAQPKEV MFPPGTRGRA RGLPYTMDAF MLGMGMLGYP NFVATYGRGY PGFAPSYGYQ FPGFPAAAYG PVAAAAVAAA RGSGSNPARP GGFPGANSPG PVADLYGPAS QDSGVGNYIS AASPQPGSGF GHGIAGPLIA TAFTNGYH
Protein Length full length protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system.
Gene References into Functions
  1. This provides proof of concept for the development of Gn-lip as a molecular therapy for colon cancer with MSI1/MSI2 overexpression. PMID: 30097032
  2. MSI2 expression is increased in epithelial cells adjacent to breast carcinoma, and increases with increasing proximity. PMID: 29093438
  3. MSI2 expression was markedly increased in both PDAC cell lines and human PDAC specimens, and high MSI2 expression was associated with poor prognosis for PDAC. Forced MSI2 expression promoted PDAC proliferation, migration, and invasion in vitro and growth and metastasis in vivo, whereas knockdown of MSI2 expression did the opposite. Dysregulated KLF4/MSI2 signaling promotes PDAC progression and metastasis. PMID: 27449499
  4. MSI1 and MSI2 bind and regulate the mRNA stability and translation of proteins operating in essential oncogenic signaling pathways..This review provides a current overview of Musashi as a cancer driver and novel therapeutic target. PMID: 28143872
  5. High MSI2 expression is associated with esophageal squamous cell carcinoma. PMID: 29054489
  6. High Musashi2 expression is associated with pancreatic cancer. PMID: 27092875
  7. MSI2 regulates myeloid leukemia stem cells gene expression. PMID: 28436985
  8. these findings provide evidence that DBC2 suppresses tumorigenesis in breast cancer by ubiquitinating MSI2. PMID: 27941885
  9. Differential methylation of the MSI2 gene (chr17:55484635) in blood and islet cells is strongly related to hyperglycemia. PMID: 28542303
  10. our findings identified a novel regulatory mechanism of MSI2 as an upstream regulator of ESR1 and revealed the clinical relevance of the RNA-binding protein MSI2 in breast cancer. PMID: 27593929
  11. MSI2 and FLT3 are significantly co-regulated in human AML PMID: 28107692
  12. MSI2 provides essential support for TGFbetaR1/SMAD3 signaling and contributes to invasive adenocarcinoma of the lung and may serve as a predictive biomarker of NSCLC aggressiveness PMID: 27274057
  13. Overexpression of Msi2 significantly increased and silencing of Msi2 reduced the phosphorylation of JAK2 and its downstream effecter STAT3. PMID: 27322953
  14. MSI2 overexpression induces paclitaxel resistance in ovarian cancer. PMID: 27600258
  15. These results indicate that the human MSI2 gene might be a susceptibility gene for schizophrenia and encourage future research on the functional relationship between this gene and schizophrenia. PMID: 27059221
  16. our study indicates that MSI-2 overexpression is associated with an unfavorable prognosis and may be a potential biomarker for liver metastasis in colorectal cancer patients. PMID: 26775684
  17. The notion that regular and close monitoring of MSI2 mRNA levels in chronic myeloid leukemia patients might identify patients at risk of progressing to blast crisis was not supported by this study; an increase in MSI2 transcripts does not precede an increase in BCR-ABL1 mRNA levels. PMID: 27160312
  18. Concomitant loss of function of both MSI1 is sufficient to abrogate the growth of human colorectal cancer cells, and Msi gene deletion inhibits tumorigenesis in several mouse models of intestinal cancer. PMID: 26673327
  19. MSI2 directly attenuates aryl hydrocarbon receptor (AHR) signalling through post-transcriptional downregulation of canonical AHR pathway components in cord blood haematopoietic stem and progenitor cells PMID: 27121842
  20. Up-regulated MSI2 is associated with more aggressive chronic myeloid leukemia. PMID: 25363400
  21. This review highlights both the essential contribution of RBPs to posttranscriptional regulation and the importance of the Musashi family as master regulators of male gamete development--{REVIEW} PMID: 25851660
  22. These results confirm the association of MSI2 expression with outcome in adult B-ALL and demonstrate the utility of MSI2 as a clinical prognostic biomarker. PMID: 25090928
  23. Msi proteins contribute to an epithelial gene expression program in neural and mammary cell types. PMID: 25380226
  24. the MSI2 RNA-binding protein has a role in transformation of intestinal epithelium PMID: 25774828
  25. MSI2 controls efficient translation of the oncogenic leukemic stem cell self-renewal program. PMID: 25664853
  26. Acute myeloid leukemia patients have a higher level of MSI2 gene expression. PMID: 25449073
  27. MSI2 correlates with epithelial-mesenchymal transition and has the potential to be a new predictive biomarker of hepatocellular carcinoma prognosis and invasion. PMID: 24305552
  28. Report a statistical difference between the MSI2 gene expression in different gastric tumor grades, of note between grade I and grade II. PMID: 24002004
  29. The Msi2 plays an important role in leukemogenesis involving the MAPK signaling pathway, which indicates that Msi2 may be a novel target for leukemia treatment. PMID: 24076374
  30. a large set of SOX2-associated proteins in DAOY medulloblastoma cells PMID: 23667531
  31. Data suggest that high MSI2 expression could indicate poor prognosis and facilitate risk and treatment stratification in adult BCR-ABL-negative B-cells acute lymphoblastic leukemia (B-ALL). PMID: 23759245
  32. MSI2 is associated with shorter overall survival in acute myeloid leukemia patients. PMID: 23233047
  33. Down-modulation of MSI2 is associated with myelodysplastic syndromes and acute myeloid leukemia. PMID: 22784712
  34. Overexpression of MSI2 resulted in a decrease in MSI1 expression. PMID: 22113197
  35. High MSI2 is associated with acute myeloid leukemia. PMID: 21753187
  36. MSI2 has a crucial role in both normal and malignant hematopoiesis. PMID: 20823875
  37. Msi2 expression is not only highly upregulated during human chronic myeloid leukemia progression but is also an early indicator of poorer prognosis PMID: 20639863
  38. The EVI1 gene locus was rearranged in all 13 myeloid malignancies patients and was associated with EVI1 overexpression. In 9 out of 13 patients, the 17q breakpoints clustered in a 250 kb region on band 17q22 encompassing the MSI2 gene PMID: 18815193

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Involvement in disease Chromosomal aberrations involving MSI2 may contribute to disease progression in chronic myeloid leukemia. Translocation t(7;17)(p15;q23) with HOXA9; translocation t(7;17)(q32-34;q23).
Subcellular Location Cytoplasm.
Protein Families Musashi family
Tissue Specificity Ubiquitous; detected at low levels.
Database Links

HGNC: 18585

OMIM: 607897

KEGG: hsa:124540

STRING: 9606.ENSP00000284073

UniGene: Hs.658922

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