Recombinant Human Rap1 GTPase-activating protein 1 (RAP1GAP)

1. This is the first mechanistic study of Rap1Gap in breast cancer progression. Decreases in Rap1Gap expression led to changes in adherens junctions via reduction in E-cadherin levels, to cytoskeletal remodeling, and to increases in ERK activation that are correlated with an invasive phenotype in DCIS PMID: 30144784
2. Rap1GAP may play a significant role in gastric cancer progression and act as a valuable prognostic marker for gastric cancer. PMID: 29758923
3. results have shown a novel role of PLCepsilon in the maintenance of endothelial barrier function, via its CDC25 GEF domain and lipase activity, and subsequent up-regulation of Rap1 activity PMID: 27612188
4. Findings suggest that RAP1 GTPase activating protein (Rap1GAP) is an important tumor suppressor with high prognostic value in endometrioid adenocarcinoma (EAC). PMID: 28196746
5. Rap1GAP is ubiquitinated and degraded through proteasome pathway in mitosis. Rap1GAP interacts with PLK1 in vivo. PMID: 25329897
6. kidney biopsies from glomerulosclerosis patients exhibited increased RAP1GAP, resulting in diminished glomerular RAP1 activation PMID: 24642466
7. findings identify Rap1GAP as a critical regulator of aggressive tumor cell behavior and suggest that the level of Rap1GAP expression influences the migratory mechanisms that are operative in tumor cells. PMID: 23864657
8. Results demonstrated that Rap1GAP promoted leukemia cell differentiation and apoptosis, but increased leukemia cell invasion in vitro. PMID: 22614916
9. Downregulation of RAP1GAP in thyroid tumors enhances SRC-dependent signals that regulate cellular architecture and motility. PMID: 22696507
10. Over-expression of Rap1GAP attenuated levels of both cadherins and integrins that are known to regulate the cancer cells invasion in renal cel carcinoma. PMID: 22266190
11. Rap1GAP is a more effective inhibitor of cell-matrix adhesion compared to cell-cell adhesion. PMID: 21785277
12. A polycomb-mediated repression of rap1GAP was demonstrated that involves EZH2, a histone methyltransferase in head and neck cancers. It was also shown that the loss of miR-101 expression correlates with EZH2 upregulation and rap1GAP downregulation. PMID: 21532618
13. These studies establish that the direct physical interaction of Rap1 with KRIT1 enables the translocation of microtubule-sequestered KRIT1 to junctions, thereby supporting junctional integrity and cardiovascular development PMID: 21633110
14. The expression level of RAP1GAp in myelodysplastic syndrome patients significantly increased as compared with patients with non-malignant blood diseases or AML. PMID: 19549374
15. Ca2+-dependent monomer and dimer formation switches CAPRI Protein between Ras GTPase-activating protein (GAP) and RapGAP activities PMID: 21460216
16. Results suggest that downregulation of Rap1GAP in epithelial tumors where alterations in cell/cell and cell/matrix adhesion are early steps in tumor dissemination supports a role for Rap1GAP depletion in tumor progression. PMID: 20439492
17. Epigenetic or genetic loss of Rap1GAP is very common in thyroid cancer, where these events are sufficient to promote cell proliferation and invasion. PMID: 20124489
18. Rap1GAP protein levels are tightly regulated and it may have a role as a tumor suppressor PMID: 14660640
19. data identify rap1GAP as a putative tumor suppressor gene in pancreatic cancer PMID: 16424023
20. Down-regulation of Rap1GAP is associated with oropharyngeal squamous cell carcinoma PMID: 16436672
21. Data implicate Rap1GAP as a putative tumor/invasion suppressor in the thyroid, and show that downregulation of Rap1GAP contributes to Ras transformation. PMID: 17646383
22. Rap1 increases KRIT-1 targeting to endothelial cell-cell junctions where it suppresses stress fibers and stabilizes junctional integrity. PMID: 17954608
23. Rap1GAP inhibits tumor growth but induces MMP2- and MMP9-mediated SCC invasion and tumor progression, suggesting a role for this protein as a biomarker for early N-stage, aggressive SCCs PMID: 18483282
24. Data propose that over-expression of RAP1GAP gene may play a role in the pathogenesis of myelodysplastic syndrome. PMID: 18551404
25. a role for Rap1GAP depletion in the progression of human thyroid tumors, possibly through unrestrained Rap activity. PMID: 19066305
26. Overexpression of Rap1GAP in melanoma cells blocks Rap1 activation and extracellular signal-regulated kinase (ERK) phosphorylation and inhibits melanoma cell proliferation and survival. PMID: 19147557
27. model in which the Ras GAP-related domain of GAP1(IP4BP) functions to stabilize the switch II region of Rap1, allowing stabilization of the transition state during GTP hydrolysis initiated by the arginine finger PMID: 19433443

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HGNC: 9858

OMIM: 600278

KEGG: hsa:5909

STRING: 9606.ENSP00000290101

UniGene: Hs.148178