Recombinant Human Serine/threonine-protein phosphatase 5 (PPP5C)

1. This work offers insights of how cantharidin-like inhibitors interact with human PP5, potentially allowing the design of more specific and even less cytotoxic drugs for cancer treatments. PMID: 30280322
2. PP5 binds and dephosphorylates the elastic N2B-unique sequence (N2Bus) of titin in cardiomyocytes. PP5 is pathologically elevated and likely contributes to hypo-phosphorylation of N2Bus in failing human hearts. Furthermore, Hsp90-activated PP5 interacts with components of a sarcomeric, N2Bus-associated, mechanosensor complex, and blocks mitogen-activated protein-kinase signaling in this complex. PMID: 29343782
3. High PPP5C expression is associated with urinary bladder cancer. PMID: 28534961
4. PP5-dependent impairment of GRalpha function represents a novel mechanism driving GC insensitivity in ASM in severe asthma. PMID: 27501780
5. Our results showed 1) a critical role for PP5 in cytokine-induced resistance to GC-mediated eosinophil death, 2) supported the dependence of GCR phosphorylation on PP5 activity, and 3) revealed that PP5 is a target of the lipoxin A4-induced pathway countering cytokine-induced resistance to GCs in eosinophils. PMID: 27742828
6. the importance of PP5 in CRC cell growth PMID: 25322973
7. PPP5C could be essential for glioma cell growth. PMID: 25796168
8. Measles Virus Infection Inactivates Cellular Protein Phosphatase 5 with Consequent Suppression of Sp1 and c-Myc Activities. PMID: 26157124
9. We demonstrate for the first time that PPP5C is essential for growth of HCC cells, which suggests that inhibition of PPP5C by RNAi may be a potential therapeutic strategy for the treatment of hepatocellular carcinoma. PMID: 25326185
10. Data indicate that Cu-oxidized S100 calcium binding protein A4 (S100A4) interacted with S100 calcium binding protein A1 (S100A1) and prevented protein phosphatase 5 (PP5) activation. PMID: 25269953
11. These results demonstrate that Hsp70 recruits PP5 and activates its phosphatase activity which suggests dual roles for PP5 that might link chaperone systems with signaling pathways in cancer and development. PMID: 24327656
12. these results suggest that caveolin-1 is a novel physiological activator of PP5. PMID: 23352616
13. Chp-1 and melusin can interact with cochaperones PP5 and Sgt1 and with each other in an ATP-dependent manner PMID: 23184943
14. Suggest that Slim/KLHDC10 is an activator of ASK1, contributing to oxidative stress-induced cell death through the suppression of PP5. PMID: 23102700
15. proasthmatic cytokine-induced corticosteroid insensitivity in airway smooth muscle cells is due, in part, to PP5-mediated impairment of glucocorticoid receptor-Ser211 phosphorylation. PMID: 22592921
16. Findings are indicative of a regulatory role of PP5 in cardiac function. PMID: 20875921
17. S100A1 and permanently active S100P inhibited the apoptosis signal-regulating kinase 1 (ASK1) and PP5 interaction, resulting the inhibition of dephosphorylation of phospho-ASK1 by PP5 PMID: 22399290
18. genetic disruption of PP5 is associated with enhanced and prolonged phosphorylation of a single serine (Ser-345) on Chk1 PMID: 21921034
19. PP5 plays a crucial role in ATR-mediated repair of UV-induced DNA damage. PMID: 21144835
20. Specific binding of PP5 to activated Rac1 provides a direct mechanism by which PP5 can be stimulated and recruited to participate in Rac1-mediated signaling pathways. PMID: 19948726
21. PP5 suppresses a pathway regulating the expression of p21(waf1) PMID: 12519780
22. protein phosphatase 5 interacts with DNA-PKcs and dephosphorylates with surprising specificity at least two functional sites. PMID: 14734805
23. structure of Serine/threonine protein phosphatase-5(PP5c) provides a structural basis for explaining the exceptional catalytic proficiency of protein phosphatases. PMID: 15155720
24. PP5 is regulated by mTOR and activates apoptosis signal-regulating kinase 1 signaling PMID: 15218033
25. PP5 plays an important role in the survival of cells in a low oxygen environment by suppressing a hypoxia-induced ASK-1/MKK4/JNK signaling cascade that promotes an apoptotic response PMID: 15328343
26. Results describe the structure of the autoinhibited state of protein phosphatase 5, revealing mechanisms of tetratricopeptide repeat-mediated phosphatase inhibition and Hsp90- and arachidonic acid-induced stimulation of phosphatase activity. PMID: 15577939
27. PP5 plays a critical role in ATR-mediated checkpoint activation PMID: 16260606
28. We report the solution structure of a complex of the TPR domain of Ppp5 with the C-terminal pentapeptide of Hsp90.This may be important for the relief of autoinhibition in Ppp5 and for the mechanisms of TPR-mediated recognition of Hsp90 by other proteins. PMID: 16531226
29. PP5, casein kinase Iepsilon, and cryptochrome dynamically regulate the mammalian circadian clock PMID: 16790549
30. PP5 is a physiological regulator of Raf-1 signalling pathways. PMID: 16892053
31. Protein phosphatase 5 as a key dephosphorylation regulator of Raf-1 activation. PMID: 17084641
32. these studies indicate that elevated levels of PP5 protein occur in human breast cancer and suggest that PP5 over-expression may aid tumor progression. PMID: 18280813
33. domain amphiphilicity is of higher importance than amino acid sequence specificity in the determination of protein adsorption and interfacial activity. PMID: 18547097
34. PP5 plays an important role in the regulation of 53BP1 phosphorylation and activity in vivo PMID: 19176521
35. Estrogen inhibits glucocorticoid action via protein phosphatase 5 (PP5)-mediated glucocorticoid receptor dephosphorylation. PMID: 19586900

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HGNC: 9322

OMIM: 600658

KEGG: hsa:5536

STRING: 9606.ENSP00000012443

UniGene: Hs.654604